Anesthetics, Local - Research News and Information

Wednesday, January 07, 2009

A randomized, prospective, double-blind trial comparing 3% chloroprocaine followed by 0.5% bupivacaine to 2% lidocaine followed by 0.5% bupivacaine for interscalene brachial plexus block.

30 Oct 2008 BACKGROUND: The combination of 2-chloroprocaine and bupivacaine (C/B) for regional anesthesia has been described, but its use was largely abandoned due to equivocal results in efficacy. In this prospective, double-blind, randomized study, we ... Read more...

Intravascular injection during ultrasound-guided axillary block: negative aspiration can be misleading.

30 Oct 2008 Needle visualization is an advantage of ultrasound-guided nerve blocks compared to traditional methods of nerve localization. However, visualization of local anesthetic spread is also important. During an ultrasound-guided axillary block, there was ... Read more...

Effects of nasal application of an epinephrine and lidocaine mixture on the hemodynamics and nasal mucosa in oral and maxillofacial surgery.

30 Oct 2008 PURPOSE: Our purpose was to investigate the influences of nasal pretreatment with a mixed solution of epinephrine and lidocaine (E-L pretreatment) on the systemic hemodynamics and the mucosa of the inferior nasal concha, which is carried out for ... Read more...

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Latest indexed articles for 'Anesthetics, Local'

These are the very latest articles for this heading:

• A randomized, prospective, double-blind trial comparing 3% chloroprocaine followed by 0.5% bupivacaine to 2% lidocaine followed by 0.5% bupivacaine for interscalene brachial plexus block. 30 Oct 2008
• Intravascular injection during ultrasound-guided axillary block: negative aspiration can be misleading. 30 Oct 2008
• Propofol associated hiccups and treatment with lidocaine. 30 Oct 2008
• Effects of nasal application of an epinephrine and lidocaine mixture on the hemodynamics and nasal mucosa in oral and maxillofacial surgery. 30 Oct 2008
• Capsaicin combined with local anesthetics preferentially prolongs sensory/nociceptive block in rat sciatic nerve. 30 Oct 2008
• Lipophilic and stereospecific interactions of amino-amide local anesthetics with human Kv1.1 channels. 30 Oct 2008
• Pharmacologic approaches for reducing venous access pain in children. 30 Oct 2008
• Essentials of skin laceration repair. 13 Oct 2008
• Musculoskeletal injections: a review of the evidence. 13 Oct 2008
• Whodunnit: the mysterious case of mediastinitis after continuous interscalene block. 29 Sep 2008
• Pharmacokinetics of levobupivacaine (2.5 mg/kg) after caudal administration in children younger than 3 years. 29 Sep 2008
• The inhibition of human neutrophil phagocytosis and oxidative burst by tricyclic antidepressants. 29 Sep 2008
• The effect of lidocaine on cholinergic neurotransmission in an identified reconstructed synapse. 29 Sep 2008
• Bronchospasm after intravenous lidocaine. 29 Sep 2008
• A comparison of the inhibitory effects of bupivacaine and levobupivacaine on isolated human pregnant myometrium contractility. 29 Sep 2008
• Use of bulleyaconitine A as an adjuvant for prolonged cutaneous analgesia in the rat. 29 Sep 2008
• Acute neck cellulitis and mediastinitis complicating a continuous interscalene block. 29 Sep 2008
• Melatonin improves tourniquet tolerance and enhances postoperative analgesia in patients receiving intravenous regional anesthesia. 29 Sep 2008
• A "new" automated bolus technique for continuous popliteal block: a prospective, randomized comparison with a continuous infusion technique. 29 Sep 2008
• Interpleural morphine vs bupivacaine for postthoracotomy pain relief. 29 Sep 2008

See a longer list of these articles.

Technical information about 'Anesthetics, Local'

Definition: Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.

Registry Number: 0

Descriptor UI: D000779

Alternative terms: Anesthetics, Local; Local Anesthetics; Conduction-Blocking Anesthetics; Conduction Blocking Anesthetics; Anesthetics, Conduction-Blocking; Anesthetics, Conduction Blocking;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D27.505.696.277.100.200; D27.505.696.663.850.025; D27.505.954.427.210.100.200;

Technical Notes: see note at ANESTHETICS