Animal Testing Alternatives - Research News and Information

Wednesday, January 07, 2009

Reconstructed epidermis and full-thickness skin for absorption testing: influence of the vehicles used on steroid permeation.

30 Aug 2008 A protocol for percutaneous absorption studies has been validated, based on the use of reconstructed human epidermis (RHE) and aqueous solutions of test substances. However, it is often the case that it is more-complex formulations of drugs or ... Read more...

Toxicity testing moves from the legislature to the petri dish-and back.

20 Aug 2008 With the growing cost of using animals to test the safety of new chemicals and an increasing backlog of chemicals awaiting testing, the quest for cell-based in vitro alternatives for toxicity testing is gaining ... Read more...

A reassessment of the in vitro RBC haemolysis assay with defibrinated sheep blood for the determination of the ocular irritation potential of cosmetic products: comparison with the in vivo Draize rabbit test.

29 Jun 2008 We examined the correlation between results obtained from the in vivo Draize test for ocular irritation and in vitro results obtained from the sheep red blood cell (RBC) haemolytic assay, which assesses haemolysis and protein denaturation in ... Read more...

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Latest indexed articles for 'Animal Testing Alternatives'

These are the very latest articles for this heading:

• Reconstructed epidermis and full-thickness skin for absorption testing: influence of the vehicles used on steroid permeation. 30 Aug 2008
• Dissemination strategies: how do they influence the uptake of the new Three Rs methods across laboratories and other boundaries? A report of a workshop held by the European Partnership for Alternative Approaches to Animal Testing (EPAA) Working Group 3. 30 Aug 2008
• Barriers to validation: a report by the European Partnership fo Alternative Approaches to Animal Testing (EPAA) Working Group 5. 30 Aug 2008
• Toxicity testing moves from the legislature to the petri dish-and back. 20 Aug 2008
• A reassessment of the in vitro RBC haemolysis assay with defibrinated sheep blood for the determination of the ocular irritation potential of cosmetic products: comparison with the in vivo Draize rabbit test. 29 Jun 2008
• Points of reference in the validation process: the report and recommendations of ECVAM Workshop 66. 29 Jun 2008
• Optimisation of the post-validation process: the report and recommendations of ECVAM Workshop 67. 29 Jun 2008
• Evaluation of the embryotoxic potency of compounds in a newly revised high throughput embryonic stem cell test. 28 Jun 2008
• Proceedings of the Congress on Alternative Test Methods in Inhalation Toxicology. May 7-9, 2007. Berlin, Germany. 30 May 2008
• Animal tests inescapable. 27 May 2008
• Preface: Congress on Alternative Test Methods in Inhalation Toxicology. 20 May 2008
• A feasibility study developing an integrated testing strategy assessing skin irritation potential of chemicals. 19 May 2008
• The challenge of reproductive and developmental toxicology under REACH. 17 May 2008
• Tobacco smoke: unraveling a controversial subject. 14 May 2008
• Alternative test methods in inhalation toxicology: challenges and opportunities. 14 May 2008
• Prevalidation of in vitro continuous flow exposure systems as alternatives to in vivo inhalation safety evaluation experimentations: outcome from MAAPHRI-PCRD5 research program. 10 May 2008
• Estimation of human blood LC50 values for use in modeling of in vitro-in vivo data of the ACuteTox project. 2 May 2008
• Complex issues with examining diesel exhaust toxicity: is the task getting easier or harder? 30 Apr 2008
• Chemical reactivity indices and mechanism-based read-across for non-animal based assessment of skin sensitisation potential. 29 Apr 2008
• [Current status of safety evaluation and alternative to animal testings in Japan] 29 Apr 2008

See a longer list of these articles.

Technical information about 'Animal Testing Alternatives'

Definition: Procedures, such as TISSUE CULTURE TECHNIQUES; mathematical models; etc., when used or advocated for use in place of the use of animals in research or diagnostic laboratories.

Descriptor UI: D000826

Alternative terms: Animal Testing Alternatives; Alternative, Animal Testing; Alternatives, Animal Testing; Animal Testing Alternative; Testing Alternative, Animal; Testing Alternatives, Animal; Alternatives to Animal Testing;

Allowable Qualifiers: classification; economics; education; history; instrumentation; legislation & jurisprudence; manpower; methods; organization & administration; standards; trends; statistics & numerical data; ethics;

Tree Number: E05.017.080.100;

History Note: 85

Technical Notes: SPEC qualif