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Anti-Inflammatory Agents, Non-Steroidal
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Definition of 'Anti-Inflammatory Agents, Non-Steroidal'

Anti-inflammatory agents that are not steroids. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They are used primarily in the treatment of chronic arthritic conditions and certain soft tissue disorders associated with pain and inflammation. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. Certain NSAIDs also may inhibit lipoxygenase enzymes or TYPE C PHOSPHOLIPASES or may modulate T-cell function. (AMA Drug Evaluations Annual, 1994, p 1814-5)

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Saturday, November 21, 2009

Comparison of topical lignocaine gel and fentanyl for perioperative analgesia in children undergoing cataract surgery.

28 Dec 2009 BACKGROUND: Opioids continue to remain the primary analgesics in children undergoing ophthalmic surgery, and their use may be associated with adverse effects like vomiting and respiratory depression. Topical anesthesia avoids these adverse effects ... Read more...


Fibromyalgia comorbidity in primary headaches.

13 Dec 2009 Fibromyalgia syndrome (FMS) is a chronic pain condition of unknown aetiology characterized by diffuse pain and tenderness at tender points. The aim of the study was to assess the prevalence and clinical features of FMS in the different forms of ... Read more...


High serum Abeta and vascular risk factors in first-degree relatives of Alzheimer's disease patients.

6 Dec 2009 The main objective of this study was to determine whether elevated blood beta-amyloid (Abeta) levels among the first-degree relatives of patients with Alzheimer's Disease (AD) are associated with vascular risk factors of AD. Serum Abeta was measured ... Read more...

 

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Technical information about 'Anti-Inflammatory Agents, Non-Steroidal'

Definition: Anti-inflammatory agents that are not steroids. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They are used primarily in the treatment of chronic arthritic conditions and certain soft tissue disorders associated with pain and inflammation. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. Certain NSAIDs also may inhibit lipoxygenase enzymes or TYPE C PHOSPHOLIPASES or may modulate T-cell function. (AMA Drug Evaluations Annual, 1994, p 1814-5)

Registry Number: 0

Descriptor UI: D000894

Alternative terms: Anti-Inflammatory Agents, Non-Steroidal; Anti Inflammatory Agents, Non Steroidal; Anti Inflammatory Agents, Nonsteroidal; NSAIDs; Antiinflammatory Agents, Non Steroidal; Antiinflammatory Agents, Nonsteroidal; Agents, Nonsteroidal Antiinflammatory; Nonsteroidal Antiinflammatory Agents; Non-Steroidal Anti-Inflammatory Agents; Agents, Non-Steroidal Anti-Inflammatory; Non Steroidal Anti Inflammatory Agents; Nonsteroidal Anti-Inflammatory Agents; Agents, Nonsteroidal Anti-Inflammatory; Anti-Inflammatory Agents, Nonsteroidal; Nonsteroidal Anti Inflammatory Agents; Anti-Rheumatic Agents, Non-Steroidal; Agents, Non-Steroidal Anti-Rheumatic; Anti Rheumatic Agents, Non Steroidal; Non-Steroidal Anti-Rheumatic Agents; Antirheumatic Agents, Non-Steroidal; Agents, Non-Steroidal Antirheumatic; Antirheumatic Agents, Non Steroidal; Non-Steroidal Antirheumatic Agents; Aspirin-Like Agents; Agents, Aspirin-Like; Aspirin Like Agents; Analgesics, Anti-Inflammatory; Analgesics, Anti Inflammatory; Anti-Inflammatory Analgesics;

Related Mesh Headings: Cyclooxygenase Inhibitors;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D27.505.696.663.850.014.040.500; D27.505.954.158.030; D27.505.954.329.030;

Online Note: use ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL to search ANALGESICS, ANTI-INFLAMMATORY 1975-89

History Note: 87; ANALGESICS, ANTI-INFLAMMATORY was heading 1975-89

Technical Notes: GEN or unspecified: prefer specifics; DF: NSAID

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