Anticonvulsants - Pharmacology
Research News and Information

Sunday, November 22, 2009

Correlation of enzyme-inducing anticonvulsant use with outcome of patients with glioblastoma.

11 Oct 2009 BACKGROUND: Clinical trials involving patients with glioblastoma (GBM) distinguish cohorts who are treated with enzyme-inducing anticonvulsants (EIAC). Such anticonvulsants induce hepatic P450 microsomal enzymes, which accelerate the metabolism of ... Read more...

Focal brain malformations: seizures, signaling, sequencing.

29 Sep 2009 Focal malformations of cortical development are highly associated with intractable epilepsy in children and adults. Most patients with focal cortical malformations and epilepsy will require epilepsy surgery. Recent studies have provided new insights ... Read more...

Differences in cortical versus subcortical GABAergic signaling: a candidate mechanism of electroclinical uncoupling of neonatal seizures.

8 Sep 2009 Electroclinical uncoupling of neonatal seizures refers to electrographic seizure activity that is not clinically manifest. Uncoupling increases after treatment with Phenobarbital, which enhances the GABA(A) receptor (GABA(A)R) conductance. The ... Read more...

Latest indexed articles for 'Anticonvulsants - Pharmacology'

These are the very latest articles for this heading:

• Correlation of enzyme-inducing anticonvulsant use with outcome of patients with glioblastoma. 11 Oct 2009
• Focal brain malformations: seizures, signaling, sequencing. 29 Sep 2009
• Differences in cortical versus subcortical GABAergic signaling: a candidate mechanism of electroclinical uncoupling of neonatal seizures. 8 Sep 2009
• Rational polytherapy. 30 Aug 2009
• Should enzyme-inducing antiepileptic drugs be considered first-line agents? 30 Aug 2009
• Mechanism of the persistent sodium current activator veratridine-evoked Ca elevation: implication for epilepsy. 29 Aug 2009
• Synthesis, in vivo evaluation, and molecular modeling studies of new pyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide derivatives. Identification of a bifunctional hydrogen bond area related to the inverse agonism. 11 Aug 2009
• The external pore loop interacts with S6 and S3-S4 linker in domain 4 to assume an essential role in gating control and anticonvulsant action in the Na(+) channel. 30 Jul 2009
• Sex differences in acute ethanol withdrawal severity after adrenalectomy and gonadectomy in Withdrawal Seizure-Prone and Withdrawal Seizure-Resistant mice. 30 Jul 2009
• Study of antiseizure effects of Matricaria recutita extract in mice. 30 Jul 2009
• Triggers of apoptosis in the immature brain. 30 Jul 2009
• Corticosteroids as treatment of epileptic syndromes with continuous spike-waves during slow-wave sleep. 30 Jul 2009
• Vigabatrin therapy in infantile spasms: solving one problem and inducing another? 30 Jul 2009
• Is the risk of vigabatrin-attributed visual field loss lower in infancy than in later life? 30 Jul 2009
• Activation of metabotropic glutamate receptor type 2/3 supports the involvement of the hippocampal mossy fiber pathway on contextual fear memory consolidation. 26 Jul 2009
• Suppressive effects of lamotrigine on the development and expression of tolerance to morphine-induced antinociception in the male mouse. 13 Jul 2009
• Inhibitory effect of methyl ethyl ketone upon the enhancement of cerebral blood flow during status epilepticus induced by lithium-pilocarpine. 12 Jul 2009
• Evidences of cannabinoids-induced modulation of paroxysmal events in an experimental model of partial epilepsy in the rat. 8 Jul 2009
• Digital neuropathy of the median and ulnar nerves caused by Dupuytren's contracture: Case report. 29 Jun 2009
• Unlocking the chemotherapeutic potential of beta-aminovinyl ketones and related compounds. 29 Jun 2009

See a longer list of these articles.

Technical information about 'Anticonvulsants'

Definition: Drugs used to prevent SEIZURES or reduce their severity.

Registry Number: 0

Descriptor UI: D000927

Alternative terms: Anticonvulsants; Anticonvulsant Drugs; Drugs, Anticonvulsant; Anticonvulsive Drugs; Drugs, Anticonvulsive; Anticonvulsive Agents; Agents, Anticonvulsive; Antiepileptic Agents; Agents, Antiepileptic; Antiepileptic Drugs; Drugs, Antiepileptic; Antiepileptics;

Related Mesh Headings: Seizures;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D27.505.954.427.080;

Technical Notes: GEN or unspecified; prefer specifics; consider also CONVULSIONS /drug ther