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Antidepressive Agents, Tricyclic - Therapeutic use
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Definition of 'Antidepressive Agents, Tricyclic'

Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system.

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Sunday, November 22, 2009

[Narcolepsy and other hypersomnias]

6 Oct 2009 BACKGROUND: Narcolepsy is currently categorized into three groups; narcolepsy with and without emotionally triggered loss of muscle tone (cataplexy), and narcolepsy secondary to other medical conditions. Many patients with hypersomnia are diagnosed ... Read more...


Nortriptyline and gabapentin, alone and in combination for neuropathic pain: a double-blind, randomised controlled crossover trial.

28 Sep 2009 BACKGROUND: Drugs for neuropathic pain have incomplete efficacy and dose-limiting side-effects when given as monotherapy. We assessed the efficacy and tolerability of combined nortriptyline and gabapentin compared with each drug given alone. ... Read more...


Impacts of switching antidepressants after successful electroconvulsive therapy on the maintenance of clinical remission in patients with treatment-resistant depression: a chart review.

30 Aug 2009 INTRODUCTION: There is no consensus regarding whether a previously prescribed, that is, failed, antidepressant should be continued or switched after a successful electroconvulsive therapy (ECT) for the maintenance of clinical remission in patients ... Read more...

 

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Technical information about 'Antidepressive Agents, Tricyclic'

Definition: Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system.

Registry Number: 0

Descriptor UI: D000929

Alternative terms: Antidepressive Agents, Tricyclic; Antidepressant Drugs, Tricyclic; Drugs, Tricyclic Antidepressant; Tricyclic Antidepressant Drugs; Antidepressants, Tricyclic; Tricyclic Antidepressants; Tricyclic Antidepressive Agents; Agents, Tricyclic Antidepressive;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D27.505.954.427.700.122.055;

History Note: 75

Technical Notes: GEN or unspecified; prefer specifics

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