Antigen-Antibody Complex - Research News and Information

Wednesday, January 07, 2009

Activation of human plasmacytoid dendritic cells by TLR9 impairs Fc gammaRII-mediated uptake of immune complexes and presentation by MHC class II.

13 Oct 2008 Human plasmacytoid dendritic cells (pDCs)(2) exploit Ag uptake receptors like CD32a for internalization of exogenous Ags. Activation of pDC by TLR9 ligand CpG-C induces strong maturation. Surprisingly, we observed that CpG-C-stimulated pDCs showed ... Read more...

Activation of human peripheral IgM+ B cells is transiently inhibited by BCR-independent aggregation of Fc gammaRIIB.

13 Oct 2008 Immune complexes can trigger a SHIP-1-independent proapoptotic signal in mouse class-switched IgG(+) B cells and plasma cells by binding to Fc gammaRIIB, in the absence of concomitant coaggregation with BCR, hence regulating plasma cell survival ... Read more...

Cutaneous leukocytoclastic vasculitis and myelodysplastic syndrome with little or no evidence of associated autoimmune disorders-a case report and a brief review of the literature.

29 Sep 2008 Cutaneous leukocytoclastic vasculitis (CLV) is a necrotizing inflammatory disease of the small vessels in the dermis. Approximately 50% of cases with CLV are primary or idiopathic and the remainder may be associated with various diseases. Less than ... Read more...

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Latest indexed articles for 'Antigen-Antibody Complex'

These are the very latest articles for this heading:

• Activation of human plasmacytoid dendritic cells by TLR9 impairs Fc gammaRII-mediated uptake of immune complexes and presentation by MHC class II. 13 Oct 2008
• Activation of human peripheral IgM+ B cells is transiently inhibited by BCR-independent aggregation of Fc gammaRIIB. 13 Oct 2008
• Cutaneous leukocytoclastic vasculitis and myelodysplastic syndrome with little or no evidence of associated autoimmune disorders-a case report and a brief review of the literature. 29 Sep 2008
• Plasmacytoid dendritic cells take up opsonized antigen leading to CD4+ and CD8+ T cell activation in vivo. 13 Sep 2008
• Anti-FGF23 neutralizing antibodies show the physiological role and structural features of FGF23. 30 Aug 2008
• Human anti-IgG1 hinge autoantibodies reconstitute the effector functions of proteolytically inactivated IgGs. 30 Aug 2008
• Nature and functions of autoantibodies. 30 Aug 2008
• [Infection and chronic kidney disease] 30 Aug 2008
• Newly proposed fibrosis staging criterion for assessing carbon tetrachloride- and albumin complex-induced liver fibrosis in rodents. 30 Aug 2008
• Anti-aquaporin-4 antibodies in neuromyelitis optica: how to prove their pathogenetic relevance? 30 Aug 2008
• Discrimination of near-native structures in protein-protein docking by testing the stability of local minima. 13 Aug 2008
• The boundary molecules in a lysozyme pattern exhibit preferential antibody binding. 11 Aug 2008
• Alternative complement pathway induction by ANCA. 5 Aug 2008
• TLR9/TLR7-triggered downregulation of BDCA2 expression on human plasmacytoid dendritic cells from healthy individuals and lupus patients. 3 Aug 2008
• Tir8/Sigirr prevents murine lupus by suppressing the immunostimulatory effects of lupus autoantigens. 19 Jul 2008
• Artificial neural network for prediction of antigenic activity for a major conformational epitope in the hepatitis C virus NS3 protein. 13 Jul 2008
• Structures of synthetic O-antigen fragments from serotype 2a Shigella flexneri in complex with a protective monoclonal antibody. 8 Jul 2008
• A randomized controlled phase IIb trial of antigen-antibody immunogenic complex therapeutic vaccine in chronic hepatitis B patients. 30 Jun 2008
• Therapeutic cleavage of IgG is dangerous in humans. 30 Jun 2008
• Systemic IFN-alpha drives kidney nephritis in B6.Sle123 mice. 29 Jun 2008

See a longer list of these articles.

Technical information about 'Antigen-Antibody Complex'

Definition: The complex formed by the binding of antigen and antibody molecules. The deposition of large antigen-antibody complexes leading to tissue damage causes IMMUNE COMPLEX DISEASES.

Registry Number: 0

Descriptor UI: D000936

Alternative terms: Antigen-Antibody Complex; Antigen Antibody Complex; Complex, Antigen-Antibody; Immune Complex; Complex, Immune; Antigen-Antibody Complexes; Antigen Antibody Complexes; Complexes, Antigen-Antibody; Immune Complexes; Complexes, Immune;

Related Mesh Headings: Immune Complex Diseases;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; biosynthesis; blood; cerebrospinal fluid; classification; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacology; physiology; poisoning; radiation effects; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Pharmacological Action: Immunologic Factors;

Tree Number: D12.776.124.486.485.114.257; D12.776.124.790.651.114.257; D12.776.377.715.548.114.257; D23.050.101;

History Note: 72(70)