Antigens, Neoplasm - Research News and Information

Wednesday, January 07, 2009

HLA-A2-restricted CTL epitopes of a novel lung cancer-associated cancer testis antigen, cell division cycle associated 1, can induce tumor-reactive CTL.

29 Nov 2008 Toward the development of a novel cancer immunotherapy, we have previously identified several tumor-associated antigens (TAAs) and the epitopes recognized by human histocompatibility leukocyte (HLA)-A2/A24-restricted cytotoxic T lymphocyte (CTL). ... Read more...

Analysis of peripheral and local anti-tumor immune response in esophageal cancer patients after NY-ESO-1 protein vaccination.

13 Nov 2008 NY-ESO-1 antigen is a prototype of a class of cancer/testis antigens. We carried out a clinical trial using NY-ESO-1 whole protein as a cancer vaccine for 13 advanced cancer patients. We have recently reported that vaccine elicited humoral and ... Read more...

Four potential biomarkers as prognostic factors in stage III serous ovarian adenocarcinomas.

30 Oct 2008 The mortality rate for patients with ovarian carcinomas is high and the available prognostic factors are insufficient. The use of biomarkers may contribute to better prediction and survival for these patients. We aimed to study the gene and protein ... Read more...

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Latest indexed articles for 'Antigens, Neoplasm'

These are the very latest articles for this heading:

• HLA-A2-restricted CTL epitopes of a novel lung cancer-associated cancer testis antigen, cell division cycle associated 1, can induce tumor-reactive CTL. 29 Nov 2008
• Analysis of peripheral and local anti-tumor immune response in esophageal cancer patients after NY-ESO-1 protein vaccination. 13 Nov 2008
• Four potential biomarkers as prognostic factors in stage III serous ovarian adenocarcinomas. 30 Oct 2008
• Confusing cases: clear cell but not renal cell lesions in kidney. 30 Oct 2008
• Detecting high-grade cervical disease on ASC-H cytology: role of BD ProEx C and Digene Hybrid Capture II HPV DNA testing. 30 Oct 2008
• What the lung has taught us about latent TGF-beta activation. 30 Oct 2008
• The stem cell niche of human livers: symmetry between development and regeneration. 30 Oct 2008
• Use of high throughput qPCR screening to rapidly clone low frequency tumour specific T-cells from peripheral blood for adoptive immunotherapy. 18 Oct 2008
• Differential presentation of tumor antigen-derived epitopes by MHC-class I and antigen-positive tumor cells. 13 Oct 2008
• Priming of a novel subset of CD28+ rapidly expanding high-avidity effector memory CTL by post maturation electroporation-CD40L dendritic cells is IL-12 dependent. 13 Oct 2008
• Roles of idiotype-specific t cells in myeloma cell growth and survival: Th1 and CTL cells are tumoricidal while Th2 cells promote tumor growth. 13 Oct 2008
• Noninvasive molecular imaging of hypoxia in human xenografts: comparing hypoxia-induced gene expression with endogenous and exogenous hypoxia markers. 13 Oct 2008
• Phosphorylation-dependent interaction between antigenic peptides and MHC class I: a molecular basis for the presentation of transformed self. 3 Oct 2008
• Tolerance to melanin-associated antigen in autoimmune uveitis is mediated by CD4+CD25+ T-regulatory cells. 30 Sep 2008
• Cancer testis antigen expression in gastrointestinal stromal tumors: new markers for early recurrence. 29 Sep 2008
• Gene expression profile of mouse prostate tumors reveals dysregulations in major biological processes and identifies potential murine targets for preclinical development of human prostate cancer therapy. 29 Sep 2008
• The utility of PAX-2 in distinguishing metastatic clear cell renal cell carcinoma from its morphologic mimics: an immunohistochemical study with comparison to renal cell carcinoma marker. 29 Sep 2008
• Expression of EpCAM is up-regulated during regeneration of renal epithelia. 29 Sep 2008
• Angiomyolipoma with epithelial cysts of the kidney in a man. 29 Sep 2008
• Identification of tumor-associated antigens in human hepatocellular carcinoma by autoantibodies. 29 Sep 2008

See a longer list of these articles.

Technical information about 'Antigens, Neoplasm'

Definition: Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.

Registry Number: 0

Descriptor UI: D000951

Alternative terms: Antigens, Neoplasm; Neoplasm Antigens; Tumor Antigens; Antigens, Tumor;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; biosynthesis; blood; cerebrospinal fluid; classification; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacology; physiology; poisoning; radiation effects; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D23.050.285;

History Note: 73

Technical Notes: coord IM with required neopl coords with /immunol (IM); Manual 24.4.4.1+