Antilipemic Agents - Toxicity
Research News and Information

Sunday, November 22, 2009

Effects of fenofibrate on plasma and hepatic transaminase activities and hepatic transaminase gene expression in rats.

29 Sep 2009 Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels are widely used as sensitive markers of possible tissue damage, particularly liver toxicity. Lipid-lowering drugs, such as fibrates, slightly increase serum ... Read more...

Lethal and sublethal effects of simvastatin, irgarol, and PBDE-47 on the estuarine fish, Fundulus heteroclitus.

29 Apr 2009 This study investigated the effects of simvastatin, a lipid-regulating drug; irgarol, an antifouling biocide; and PBDE-47, a brominated flame retardant, on the estuarine fish, Fundulus heteroclitus. Sublethal effects (changes in glutathione (GSH), ... Read more...

Fenofibrate-induced muscular toxicity is associated with a metabolic shift limited to type-1 muscles in rats.

22 Apr 2009 Morphological changes and mRNA expression levels in type-1 predominant soleus and type-2 predominant tensor fasciae latae muscles of rats treated with fenofibrate were investigated. After fenofibrate by oral gavage at 300 mg/kg/day for 28 days, ... Read more...

Latest indexed articles for 'Antilipemic Agents - Toxicity'

These are the very latest articles for this heading:

• Effects of fenofibrate on plasma and hepatic transaminase activities and hepatic transaminase gene expression in rats. 29 Sep 2009
• Lethal and sublethal effects of simvastatin, irgarol, and PBDE-47 on the estuarine fish, Fundulus heteroclitus. 29 Apr 2009
• Fenofibrate-induced muscular toxicity is associated with a metabolic shift limited to type-1 muscles in rats. 22 Apr 2009
• Acute hepatitis caused by a natural lipid-lowering product: when "alternative" medicine is no "alternative" at all. 29 Mar 2009
• A phase II clinical trial does not show that high dose simvastatin has beneficial effect on markers of bone turnover in multiple myeloma. 27 Feb 2009
• [Drug-induced testicular toxicity] 30 Jan 2009
• Untargeted metabolomic profiling as an evaluative tool of fenofibrate-induced toxicology in Fischer 344 male rats. 30 Dec 2008
• Contents of phytosterols in vegetables and fruits commonly consumed in China. 29 Nov 2008
• The effects of pharmaceuticals on the regeneration of the cnidarian, Hydra attenuata. 3 Jun 2008
• Genotoxicity of alpha-asarone analogues. 23 Apr 2008
• Administration of ciprofibrate to lactating mothers induces PPARalpha-signaling pathway in the liver and kidney of suckling rats. 20 Apr 2008
• Beneficial effects of Lagenaria siceraria (Mol.) Standley fruit epicarp in animal models. 30 Mar 2008
• Possible involvement of oxidative stress in fenofibrate-induced hepatocarcinogenesis in rats. 4 Feb 2008
• Dietary clofibrate stimulates the formation and size of estradiol-induced breast tumors in female August-Copenhagen Irish (ACI) rats. 4 Jan 2008
• Ciprofibrate, clofibric acid and respective glycinate derivatives. Effects of a four-week treatment on male lean and obese Zucker rats. 30 Dec 2007
• Clofibrate and gemfibrozil induce an embryonic malabsorption syndrome in zebrafish. 26 Nov 2007
• Evaluation of reproductive safety of beta-sitosterol on the American mink (Neovison vison). 24 Nov 2007
• Anti-diabetic, anti-hyperlipidemic and spermatogenic effects of Amaranthus spinosus Linn. on streptozotocin-induced diabetic rats. 21 Aug 2007
• Preliminary studies into the effects of the human pharmaceutical Clofibric acid on sperm parameters in adult Fathead minnow. 14 Jun 2007
• Effects of blood lipid lowering pharmaceuticals (bezafibrate and gemfibrozil) on immune and digestive gland functions of the bivalve mollusc, Mytilus galloprovincialis. 13 Jun 2007

See a longer list of these articles.

Technical information about 'Antilipemic Agents'

Definition: Substances used to treat HYPERLIPIDEMIAS.

Registry Number: 0

Descriptor UI: D000960

Alternative terms: Antilipemic Agents; Agents, Antilipemic; Antihyperlipidemics; Antihyperlipemics; Antilipemics; Antilipemic Drugs; Drugs, Antilipemic; Hypolipidemic Agents; Agents, Hypolipidemic;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D27.505.519.186.071; D27.505.954.230;

History Note: 72(66)