Antineoplastic Agents, Phytogenic
Research News and Information

Saturday, November 21, 2009

Vincristine: Can its therapeutic index be enhanced?

13 Dec 2009 Vincristine is one of the most widely used and more effective drugs in paediatric oncology. The dose-limiting toxicity of neuropathy, lack of proven neuroprotective measures and an incomplete understanding of the pharmacokinetics and ... Read more...

Irinotecan and temozolomide for Ewing sarcoma: the Memorial Sloan-Kettering experience.

29 Nov 2009 BACKGROUND: The prognosis for recurrent/progressive Ewing sarcoma (ES) remains poor. Pre-clinical, adult phase I and II trials have demonstrated the combination of irinotecan and temozolomide to have schedule-dependent synergy and significant ... Read more...

From glioblastoma to gangliocytoma: an unforeseen but welcome shift in biological behavior.

30 Oct 2009 The prognosis in children harboring a glioblastoma multiforme (GBM) is usually poor. Few GBMs in children, however, seem to respond quite well to adjuvant chemotherapy. The biological basis for such chemotherapy sensitivity remains uncertain. In ... Read more...

Latest indexed articles for 'Antineoplastic Agents, Phytogenic'

These are the very latest articles for this heading:

• Vincristine: Can its therapeutic index be enhanced? 13 Dec 2009
• Irinotecan and temozolomide for Ewing sarcoma: the Memorial Sloan-Kettering experience. 29 Nov 2009
• From glioblastoma to gangliocytoma: an unforeseen but welcome shift in biological behavior. 30 Oct 2009
• Combination of vandetanib, radiotherapy, and irinotecan in the LoVo human colorectal cancer xenograft model. 30 Oct 2009
• Second-line chemotherapy with biweekly paclitaxel after failure of fluoropyrimidine-based treatment in patients with advanced or recurrent gastric cancer: a report from the gastrointestinal oncology group of the Tokyo cooperative oncology group, TCOG GC-0501 trial. 4 Oct 2009
• Fern plant-derived protoapigenone leads to DNA damage, apoptosis, and G(2)/m arrest in lung cancer cell line H1299. 29 Sep 2009
• Propranolol for airway hemangiomas: case report of novel treatment. 29 Sep 2009
• Benefits of drug-eluting stents as compared to bare metal stent in ST-segment elevation myocardial infarction: four year results of the PaclitAxel or Sirolimus-Eluting stent vs bare metal stent in primary angiOplasty (PASEO) randomized trial. 29 Sep 2009
• Amplification of the ABCB1 region accompanied by a short sequence of 200bp from chromosome 2 in lung cancer cells. 29 Sep 2009
• Phase II evaluation of intravenous vinorelbine (Navelbine) in recurrent or refractory pediatric malignancies: a Children's Oncology Group study. 29 Sep 2009
• Induction of apoptosis and cell cycle arrest in human HCC MHCC97H cells with Chrysanthemum indicum extract. 26 Sep 2009
• Novel ceramides from aerial parts of Saussurea involucrata Kar. et. Kir. 24 Sep 2009
• A novel model and experimental analysis of hydrophilic and hydrophobic agent release from biodegradable polymers. 13 Sep 2009
• Biscoclaurine alkaloid cepharanthine inhibits the growth of primary effusion lymphoma in vitro and in vivo and induces apoptosis via suppression of the NF-kappaB pathway. 13 Sep 2009
• Cytotoxic, cytoprotective and antioxidant activities of resveratrol and analogues in C6 astroglioma cells in vitro. 6 Sep 2009
• FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt. 6 Sep 2009
• Resveratrol suppresses growth of human ovarian cancer cells in culture and in a murine xenograft model: eukaryotic elongation factor 1A2 as a potential target. 6 Sep 2009
• Effect of low-dose Paclitaxel and docetaxel on endothelial progenitor cells. Sep 2009
• Leucophyllidine, a cytotoxic bisindole alkaloid constituted from the union of an eburnan and a new vinylquinoline alkaloid. Sep 2009
• Colorectal cancer: Irinotecan therapy-following a trail of breadcrumbs? 30 Aug 2009

See a longer list of these articles.

Technical information about 'Antineoplastic Agents, Phytogenic'

Definition: Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.

Registry Number: 0

Descriptor UI: D000972

Alternative terms: Antineoplastic Agents, Phytogenic; Agents, Phytogenic Antineoplastic; Phytogenic Antineoplastic Agents; Antineoplastics, Phytogenic; Phytogenic Antineoplastics; Antineoplastics, Botanical; Botanical Antineoplastics;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists; biosynthesis;

Tree Number: D27.505.954.248.179;

Online Note: use ANTINEOPLASTIC AGENTS, PHYTOGENIC to search ANTINEOPLASTICS, PHYTOGENIC 1975

History Note: 76; was ANTINEOPLASTICS, PHYTOGENIC 1975

Technical Notes: from plants of Cat B6 only, not from lower plants (Cat B5: algae & fungi); /biosyn permitted if by plant; TN 4: coverage