Antineoplastic Agents, Phytogenic - Research News and Information

Thursday, January 08, 2009

Mitotic catastrophe and apoptosis induced by docetaxel in hormone-refractory prostate cancer cells.

30 Oct 2008 Studies performed in different experimental and clinical settings have shown that Docetaxel (Doc) is effective in a wide range of tumors and that it exerts its activity through multiple mechanisms of action. However, the sequence of events induced ... Read more...

Activation of apoptosis by 1-hydroxy-5,7-dimethoxy-2-naphthalene-carboxaldehyde, a novel compound from Aegle marmelos.

13 Oct 2008 We have identified a natural compound that activates apoptosis of epithelial cancer cells through activation of tumor necrosis factor-alpha (TNF-alpha), TNF receptor (TNFR)-associated death domain (TRADD), and caspases. The molecule ... Read more...

Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis.

8 Oct 2008 Germline mutations of BRCA1 predispose women to breast and ovarian cancers. However, the downstream mediators of BRCA1 function in tumor suppression remain elusive. We found that human BRCA1-associated breast cancers have lower levels of SIRT1 than ... Read more...

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Latest indexed articles for 'Antineoplastic Agents, Phytogenic'

These are the very latest articles for this heading:

• Mitotic catastrophe and apoptosis induced by docetaxel in hormone-refractory prostate cancer cells. 30 Oct 2008
• Activation of apoptosis by 1-hydroxy-5,7-dimethoxy-2-naphthalene-carboxaldehyde, a novel compound from Aegle marmelos. 13 Oct 2008
• Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis. 8 Oct 2008
• Lignans from the roots of Saururus chinensis. 6 Oct 2008
• Enhanced cytotoxicity of saporin by polyamidoamine dendrimer conjugation and photochemical internalization. 29 Sep 2008
• Irinotecan and uridine diphosphate glucuronosyltransferase 1A1 pharmacogenetics: to test or not to test, that is the question. 29 Sep 2008
• Low doses of paclitaxel potently induce apoptosis in human retinoblastoma Y79 cells by up-regulating E2F1. 29 Sep 2008
• Induction of cell cycle arrest and apoptosis in myeloma cells by cepharanthine, a biscoclaurine alkaloid. 29 Sep 2008
• Metabolism of irinotecan and its active metabolite SN-38 by intestinal microflora in rats. 29 Sep 2008
• Piplartine induces caspase-mediated apoptosis in PC-3 human prostate cancer cells. 29 Sep 2008
• Docetaxel chemotherapy for metastatic hormone refractory prostate cancer as first-line palliative chemotherapy and subsequent re-treatment: Birmingham experience. 29 Sep 2008
• Tyrianthinic acids from Ipomoea tyrianthina and their antimycobacterial activity, cytotoxicity, and effects on the central nervous system. 29 Sep 2008
• Conversion of optically active hydrindanone to (+)-bakkenolide-A. 29 Sep 2008
• Cytotoxic and anti-oxidant activities of lanostane-type triterpenes isolated from Poria cocos. 29 Sep 2008
• Structural development of benzhydrol-type 1'-acetoxychavicol acetate (ACA) analogs as human leukemia cell-growth inhibitors based on quantitative structure-activity relationship (QSAR) analysis. 29 Sep 2008
• Incidence and correlates of drug-eluting stent thrombosis in routine clinical practice. 4-year results from a large 2-institutional cohort study. 28 Sep 2008
• "POBA Plus": will the balloon regain its luster? 21 Sep 2008
• 2,2-dimethyl-2H-pyran-derived alkaloids I. Practical synthesis of acronycine and benzo[b]acronycine and their biological properties. 18 Sep 2008
• Continentalic acid from Aralia continentalis induces growth inhibition and apoptosis in HepG2 cells. 18 Sep 2008
• Inhibition of cell growth and invasion by epidermal growth factor-targeted phagemid particles carrying siRNA against focal adhesion kinase in the presence of hydroxycamptothecin. 16 Sep 2008

See a longer list of these articles.

Technical information about 'Antineoplastic Agents, Phytogenic'

Definition: Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.

Registry Number: 0

Descriptor UI: D000972

Alternative terms: Antineoplastic Agents, Phytogenic; Agents, Phytogenic Antineoplastic; Phytogenic Antineoplastic Agents; Antineoplastics, Phytogenic; Phytogenic Antineoplastics; Antineoplastics, Botanical; Botanical Antineoplastics;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists; biosynthesis;

Tree Number: D27.505.954.248.179;

Online Note: use ANTINEOPLASTIC AGENTS, PHYTOGENIC to search ANTINEOPLASTICS, PHYTOGENIC 1975

History Note: 76; was ANTINEOPLASTICS, PHYTOGENIC 1975

Technical Notes: from plants of Cat B6 only, not from lower plants (Cat B5: algae & fungi); /biosyn permitted if by plant; TN 4: coverage