Antineoplastic Agents - Research News and Information

Thursday, January 08, 2009

Bicalutamide inhibits androgen-mediated adhesion of prostate cancer cells exposed to ionizing radiation.

29 Nov 2008 BACKGROUND: Cell adhesion plays an important role in proliferation, metastasis, and tumor growth and may represent a potential vulnerability in treatment of prostate cancer patients. Bicalutamide (Casodex) has been used as an anti-androgen agent ... Read more...

Prolonged androgen receptor loading onto chromatin and the efficient recruitment of p160 coactivators contribute to androgen-independent growth of prostate cancer cells.

29 Nov 2008 BACKGROUND: Growth of most ablation-resistant prostate cancers (CaPs) is dependent on androgen receptor (AR) activity in chromatin, but cancer cells in these tumors have acquired altered AR activation. It is unclear how the aberrantly activated AR ... Read more...

Original triazine inductor of new specific molecular targets, with antitumor activity against nonsmall cell lung cancer.

29 Nov 2008 Despite our growing insight into carcinogenesis, treatment of tumors, especially nonsmall cell lung cancer (NSCLC), remains limited and it is urgent to develop strategies that target tumor cells and their genetic features. Drug discovery efforts ... Read more...

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Latest indexed articles for 'Antineoplastic Agents'

These are the very latest articles for this heading:

• Bicalutamide inhibits androgen-mediated adhesion of prostate cancer cells exposed to ionizing radiation. 29 Nov 2008
• Prolonged androgen receptor loading onto chromatin and the efficient recruitment of p160 coactivators contribute to androgen-independent growth of prostate cancer cells. 29 Nov 2008
• Original triazine inductor of new specific molecular targets, with antitumor activity against nonsmall cell lung cancer. 29 Nov 2008
• Biophysical and biochemical characterization of a liposarcoma-derived recombinant MnSOD protein acting as an anticancer agent. 29 Nov 2008
• Anti-adult T-cell leukemia effects of brown algae fucoxanthin and its deacetylated product, fucoxanthinol. 29 Nov 2008
• Short hairpin RNA targeting c-FLIP sensitizes human cervical adenocarcinoma Hela cells to chemotherapy and radiotherapy. 26 Nov 2008
• ApoG2, a novel inhibitor of antiapoptotic Bcl-2 family proteins, induces apoptosis and suppresses tumor growth in nasopharyngeal carcinoma xenografts. 13 Nov 2008
• Targeting the methionine cycle for melanoma therapy with 3-O-(3,4,5-trimethoxybenzoyl)-(-)-epicatechin. 13 Nov 2008
• Predictive value of thymidylate synthase expression in advanced colorectal cancer patients receiving fluoropyrimidine-based chemotherapy: evidence from 24 studies. 13 Nov 2008
• The antitumor activity of an anti-CD54 antibody in SCID mice xenografted with human breast, prostate, non-small cell lung, and pancreatic tumor cell lines. 13 Nov 2008
• Cannabislike drugs may hold key to treating pain while bypassing the brain. 3 Nov 2008
• [Extranodal marginal zone lymphoma of the ocular adnexa] Nov 2008
• [Monitoring renal function in patients treated with cytostatics] Nov 2008
• S10 phosphorylation of p27 mediates atRA induced growth arrest in ovarian carcinoma cell lines. 30 Oct 2008
• Tumor immune surveillance defect of X-linked severe combined immunodeficiency is not Epstein-Barr virus specific. 30 Oct 2008
• Clofarabine in refractory Langerhans cell histiocytosis. 30 Oct 2008
• Myocardial iron overload in transfusion-dependent pediatric patients with acute leukemia. 30 Oct 2008
• PML/RARalpha fusion protein mediates the unique sensitivity to arsenic cytotoxicity in acute promyelocytic leukemia cells: Mechanisms involve the impairment of cAMP signaling and the aberrant regulation of NADPH oxidase. 30 Oct 2008
• Pediatric oncology sedation trial (POST): A double-blind randomized study. 30 Oct 2008
• Encephalopathy syndrome in children with hemato-oncological disorders is not always posterior and reversible. 30 Oct 2008

See a longer list of these articles.

Technical information about 'Antineoplastic Agents'

Definition: Substances that inhibit or prevent the proliferation of NEOPLASMS.

Registry Number: 0

Descriptor UI: D000970

Alternative terms: Antineoplastic Agents; Agents, Antineoplastic; Antineoplastics; Antitumor Drugs; Drugs, Antitumor; Antineoplastic Drugs; Drugs, Antineoplastic; Antitumor Agents; Agents, Antitumor;

Related Mesh Headings: Cytotoxins; Infusions, Intra-Arterial; Chemotherapy, Cancer, Regional Perfusion; Tumor Lysis Syndrome; Chemoembolization, Therapeutic; Anticarcinogenic Agents;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D27.505.954.248;

Technical Notes: /admin: various administration procedures are available, as CHEMOTHERAPY, CANCER, REGIONAL PERFUSION; CHEMOEMBOLIZATION, THERAPEUTIC and INFUSIONS, INTRA-ARTERIAL; for combined anticancer agents, ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS is available; Manual 24.4.2.1+