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Antipsychotic Agents - Research News and Information

Thursday, January 08, 2009

Definition of 'Antipsychotic Agents'

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in schizophrenia, senile dementia, transient psychosis following surgery or myocardial infarction, etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.

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Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats.

6 Oct 2008 Recent studies suggest that subtype-selective activators of M(1)/M(4) muscarinic acetylcholine receptors (mAChRs) may offer a novel approach for the treatment of psychotic symptoms associated with schizophrenia and Alzheimer's disease. Previously ... Read more...


Clozapine and myocarditis: a case series from the New Zealand Intensive Medicines Monitoring Programme.

Oct 2008 AIM: To examine a New Zealand case series of clozapine-associated myocarditis. METHODS: All cases of myocarditis in the Intensive Medicines Monitoring Programme's (IMMP) clozapine database were identified and reviewed. RESULTS: 25 cases of ... Read more...


Coregulation of genes in the mouse brain following treatment with clozapine, haloperidol, or olanzapine implicates altered potassium channel subunit expression in the mechanism of antipsychotic drug action.

29 Sep 2008 BACKGROUND: Antipsychotic drugs are the most effective treatment for the psychotic symptoms of schizophrenia, yet their mechanism of action remains largely unknown. OBJECTIVES: Earlier studies have shown gene expression changes in rodent brains ... Read more...

 

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Technical information about 'Antipsychotic Agents'

Definition: Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in schizophrenia, senile dementia, transient psychosis following surgery or myocardial infarction, etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.

Registry Number: 0

Descriptor UI: D014150

Alternative terms: Antipsychotic Agents; Agents, Antipsychotic; Tranquilizing Agents, Major; Agents, Major Tranquilizing; Major Tranquilizing Agents; Tranquillizing Agents, Major; Agents, Major Tranquillizing; Major Tranquillizing Agents; Major Tranquilizers; Tranquilizers, Major; Antipsychotics; Antipsychotic Drugs; Drugs, Antipsychotic; Neuroleptic Drugs; Drugs, Neuroleptic; Neuroleptics; Neuroleptic Agents; Agents, Neuroleptic;

Related Mesh Headings: Dopamine Antagonists;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D27.505.696.277.950.040; D27.505.954.427.210.950.040; D27.505.954.427.700.872.331;

Online Note: use ANTIPSYCHOTIC AGENTS to search TRANQUILIZING AGENTS, MAJOR 1975-94; use TRANQUILIZING AGENTS to search NEUROLEPTICS 1969-94

History Note: 95; was TRANQUILIZING AGENTS, MAJOR 1975-94; ANTIPSYCHOTIC AGENTS was see TRANQUILIZING AGENTS, MAJOR 1975-94; NEUROLEPTICS was see TRANQUILIZING AGENTS 1975-78, was see under TRANQUILIZING AGENTS 1969-74

Technical Notes: GEN or unspecified; prefer specific groups or specific drugs; consider also PSYCHOSES /drug ther

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