Antithrombins - Pharmacology
Research News and Information

Sunday, March 21, 2010

Automated assay for fondaparinux (Arixtra) on the Dade Behring BCS XP.

29 Sep 2009 An assay for fondaparinux (Arixtra) is described based on a modified commercial assay for heparin. The assay is automated on a Dade Behring BCS XP (Siemens Healthcare Diagnostics, Deerfield, IL) and uses the inhibition of activated factor X to ... Read more...

Anticoagulant mechanisms of covalent antithrombin-heparin investigated by thrombelastography. Comparison with unfractionated heparin and low-molecular-weight heparin.

29 Jun 2009 We have developed an antithrombin-heparin covalent complex (ATH) which inhibits coagulation enzymes by two mechanisms: directly, or by catalytic activation of plasma antithrombin (AT). Anticoagulation by ATH was compared to unfractionated heparin ... Read more...

Nitric oxide-releasing S-nitrosothiol-modified xerogels.

4 Jun 2009 The synthesis, material characterization, and in vitro biocompatibility of S-nitrosothiol (RSNO)-modified xerogels are described. Thiol-functionalized xerogel films were formed by hydrolysis and co-condensation of 3-mercaptopropyltrimethoxysilane ... Read more...

Latest indexed articles for 'Antithrombins - Pharmacology'

These are the very latest articles for this heading:

• Recombinant human antithrombin (ATryn). 17 Oct 2009
• Automated assay for fondaparinux (Arixtra) on the Dade Behring BCS XP. 29 Sep 2009
• Anticoagulant mechanisms of covalent antithrombin-heparin investigated by thrombelastography. Comparison with unfractionated heparin and low-molecular-weight heparin. 29 Jun 2009
• Nitric oxide-releasing S-nitrosothiol-modified xerogels. 4 Jun 2009
• Interaction of antithrombin with sulfated, low molecular weight lignins: opportunities for potent, selective modulation of antithrombin function. 2 Jun 2009
• Intravascular targeting of a new anticoagulant heparin compound. 30 May 2009
• Antithrombin reduces shedding of the endothelial glycocalyx following ischaemia/reperfusion. 20 Mar 2009
• Characterization of a heparin-binding site on the catalytic domain of factor XIa: mechanism of heparin acceleration of factor XIa inhibition by the serpins antithrombin and C1-inhibitor. 22 Feb 2009
• Regulation of thrombin generation by TFPI in plasma without and with heparin. 5 Jan 2009
• Mechanism of thrombin inhibition by heparin cofactor II and antithrombin in the presence of the ray (Raja radula) skin dermatan sulfate. 26 Nov 2008
• On designing non-saccharide, allosteric activators of antithrombin. 7 Oct 2008
• TNF-alpha induced shedding of the endothelial glycocalyx is prevented by hydrocortisone and antithrombin. Oct 2008
• Intraspecies differences in hemostatic venom activities of the South American rattlesnakes, Crotalus durissus cumanensis, as revealed by a range of protease inhibitors. 30 Aug 2008
• A comparison of the pharmacokinetics of antithrombin derived from human plasma and from transgenic goats and the prevention of sepsis in an animal model. 30 Aug 2008
• 3,4-Dihydro-2H-1,4-benzoxazine derivatives combining thrombin inhibitory and glycoprotein IIb/IIIa receptor antagonistic activity as a novel class of antithrombotic compounds with dual function. 25 Aug 2008
• Bivalirudin decreases NO bioavailability by vascular immobilization of myeloperoxidase. 11 Aug 2008
• Activity and regulation of glycoPEGylated factor VIIa analogs. 2 Jul 2008
• Low plasma fibrinogen levels with the Clauss method during anticoagulation with bivalirudin. 29 Jun 2008
• Monitoring direct FXa-inhibitors and fondaparinux by Prothrombinase-induced Clotting Time (PiCT): relation to FXa-activity and influence of assay modifications. 22 Jun 2008
• Sulfated galactan is a catalyst of antithrombin-mediated inactivation of alpha-thrombin. 26 May 2008

See a longer list of these articles.

Technical information about 'Antithrombins'

Definition: An endogenous family of proteins belonging to the serpin superfamily that neutralizes the action of thrombin. Six naturally occurring antithrombins have been identified and are designated by Roman numerals I to VI. Of these, Antithrombin I (see FIBRIN) and ANTITHROMBIN III appear to be of major importance.

Registry Number: 0

Descriptor UI: D000991

Alternative terms: Antithrombins;

Related Mesh Headings: Anticoagulants;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; biosynthesis; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.776.872.060;

Online Note: use ANTITHROMBINS to search ANTITHROMBIN 1967-76 (as Prov 1966)

History Note: 76; was ANTITHROMBIN 1964-75 (Prov 1964-66)

Technical Notes: serpins & anticoagulants