Antitussive Agents
Research News and Information

Sunday, November 22, 2009

Discovery of orally active 3-pyridinyl-tropane as a potent nociceptin receptor agonist for the management of cough.

8 Sep 2009 A series of 3-pyridinyl-tropane analogues based on previously reported compound 1 have been synthesized and shown to bind to the nociceptin receptor with high affinity. From the SAR study and our lead optimization efforts, compound 10 was found to ... Read more...

Prescribed medications and pharmacy interventions for acute respiratory tract infections in Swiss primary care.

30 Jul 2009 BACKGROUND AND OBJECTIVES: Symptomatic medications are often not considered in clinical studies assessing interventions to reduce prescribing of antibiotics for acute respiratory tract infections (ARTI). Our study objectives were to examine ... Read more...

[Cough syncope caused by a possible Chlamydia pneumoniae pneumonia]

5 Jul 2009 We report the case of a 61-year-old man who presented with coughing fits followed by sinus pauses and syncope. Cardiac and neurological diagnostic work-up was negative and the patient was considered to have cough syncope. As this occurred within the ... Read more...

Latest indexed articles for 'Antitussive Agents'

These are the very latest articles for this heading:

• Discovery of orally active 3-pyridinyl-tropane as a potent nociceptin receptor agonist for the management of cough. 8 Sep 2009
• Prescribed medications and pharmacy interventions for acute respiratory tract infections in Swiss primary care. 30 Jul 2009
• More discussion of over the counter cough and cold preparations. 30 Jul 2009
• [Cough syncope caused by a possible Chlamydia pneumoniae pneumonia] 5 Jul 2009
• Towards evidence based emergency medicine: Best BETs from the Manchester Royal Infirmary. Bet 3. Honey for the symptomatic relief of cough in children with upper respiratory tract infections. 29 Jun 2009
• Adverse reactions to over-the-counter cough and cold products among children: the cases managed out of hospitals. 30 May 2009
• Cough in the palliative care setting. 30 May 2009
• For young children, many OTC products are out in the cold. 30 May 2009
• Parental misinterpretations of over-the-counter pediatric cough and cold medication labels. 30 May 2009
• Unclear loss of consciousness after clobutinol intake. 19 May 2009
• [Pharmacological treatment of acute cough] 12 May 2009
• Dose-response relationship for the pharmacokinetic interaction of grapefruit juice with dextromethorphan investigated by human urinary metabolite profiles. 11 May 2009
• N-of-1 double-blind, randomized controlled trial of tramadol to treat chronic cough. 29 Apr 2009
• Addictive evaluation of cholic acid-verticinone ester, a potential cough therapeutic agent with agonist action of opioid receptor. 29 Apr 2009
• AV conduction block and proximal myopathy induced by Gee's cough linctus. 22 Apr 2009
• Honey and lozenges for children with non-specific cough. 13 Apr 2009
• Possible mechanisms of dose-dependent cough suppressive effect of Althaea officinalis rhamnogalacturonan in guinea pigs test system. 31 Mar 2009
• Proceedings of the 2008 Fifth International Symposium on Cough, 26-28 June 2008, London, UK. 30 Mar 2009
• Identification of 3-substituted N-benzhydryl-nortropane analogs as nociceptin receptor ligands for the management of cough and anxiety. 16 Mar 2009
• The discovery of tropane derivatives as nociceptin receptor ligands for the management of cough and anxiety. 12 Mar 2009

See a longer list of these articles.

Technical information about 'Antitussive Agents'

Definition: Agents that suppress cough. They act centrally on the medullary cough center. EXPECTORANTS, also used in the treatment of cough, act locally.

Registry Number: 0

Descriptor UI: D000996

Alternative terms: Antitussive Agents; Agents, Antitussive; Antitussive Drugs; Drugs, Antitussive; Antitussives;

Related Mesh Headings: Expectorants;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D27.505.954.427.153; D27.505.954.796.090;

Technical Notes: GEN or unspecified; consider also COUGH /drug ther