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Apamin - Research News and Information
Thursday, January 08, 2009
Definition of 'Apamin'A highly neurotoxic polypeptide from the venom of the honey bee (Apis mellifera). It consists of 18 amino acids with two disulfide bridges and causes hyperexcitability resulting in convulsions and respiratory paralysis. Common names: Apamin |
12 Aug 2008 
Small-conductance Ca2+-activated K+ (SK) channels are widely expressed in neuronal tissues where they underlie post-spike hyperpolarizations, regulate spike-frequency adaptation, and shape synaptic responses. SK channels constitutively interact ... Read more...
12 Aug 2008 An initial SAR study on a series of apamin-displacing 2-aminothiazole K(Ca)2 channel blockers is described. Potent inhibitors such as N-(4-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine (13) are disclosed, and for select members of the series, ... Read more...
30 Jul 2008 BACKGROUND: We investigated the role of calcium-activated potassium (K(Ca)) channel activity in human skeletal muscle microvascular function in the setting of cardiopulmonary bypass (CPB). METHODS AND RESULTS: Human skeletal muscle arterioles (80- ... Read more...
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Latest indexed articles for 'Apamin'
These are the very latest articles for this heading:
- Neurotransmitter modulation of small-conductance Ca2+-activated K+ channels by regulation of Ca2+ gating. 12 Aug 2008
- Initial SAR studies on apamin-displacing 2-aminothiazole blockers of calcium-activated small conductance potassium channels. 12 Aug 2008
- Calcium-activated potassium channels contribute to human skeletal muscle microvascular endothelial dysfunction related to cardiopulmonary bypass. 30 Jul 2008
- Hydrogen peroxide potentiates the EDHF phenomenon by promoting endothelial Ca2+ mobilization. 29 Jul 2008
- Plasmodium falciparum: growth response to potassium channel blocking compounds. 28 Jul 2008
- Relationship between afterhyperpolarization profiles and the regularity of spontaneous firings in rat medial vestibular nucleus neurons. 29 Jun 2008
- The mechanisms of propofol-induced block on ion currents in differentiated H9c2 cardiac cells. 22 Jun 2008
- Calcitonin gene-related peptide inhibits angiotensin II-mediated vasoconstriction in human radial arteries: role of the Kir channel. 17 Jun 2008
- Temporal processing across multiple topographic maps in the electrosensory system. 26 May 2008
- Small-conductance Ca(2+)-activated K(+) channels: Heterogeneous affinity in rat brain structures and cognitive modulation by specific blockers. 21 May 2008
- Involvement of soluble guanylate cyclase alpha(1) and alpha(2), and SK(Ca) channels in NANC relaxation of mouse distal colon. 21 May 2008
- Potassium channel contributions to afferent arteriolar tone in normal and diabetic rat kidney. 19 May 2008
- T-type Ca2+ channels, SK2 channels and SERCAs gate sleep-related oscillations in thalamic dendrites. 16 May 2008
- 15-Lipoxygenase metabolites contribute to age-related reduction in acetylcholine-induced hypotension in rabbits. 30 Apr 2008
- Critical role for small and large conductance calcium-dependent potassium channels in endotoxemia and TNF toxicity. 29 Apr 2008
- Does the endothelium abolish or promote arterial vasomotion in rat mesenteric arteries? Explanations for the seemingly contradictory effects. 7 Apr 2008
- Potassium channels sensitive to combination of charybdotoxin and apamin regulate the tone of diabetic isolated canine coronary arteries. Apr 2008
- Small-conductance calcium-activated potassium channels control excitability and firing dynamics in gonadotropin-releasing hormone (GnRH) neurons. 25 Mar 2008
- Iberiotoxin-sensitive large conductance Ca2+ -dependent K+ (BK) channels regulate the spike configuration in the burst firing of cerebellar Purkinje neurons. 25 Mar 2008
- Estrogen and the Ca2+-mobilizing agonist ATP evoke acute NO synthesis via distinct pathways in an individual human vascular endothelium-derived cell. 24 Mar 2008
See a longer list of these articles.
Technical information about 'Apamin'
Definition: A highly neurotoxic polypeptide from the venom of the honey bee (Apis mellifera). It consists of 18 amino acids with two disulfide bridges and causes hyperexcitability resulting in convulsions and respiratory paralysis.
Chemical name: Apamin
Registry Number: 24345-16-2
Descriptor UI: D001030
Alternative terms: Apamin;
Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;
Tree Number: D20.888.065.115.060; D23.946.833.065.115.060;
History Note: 91(78); was see under BEE VENOMS 1978-90
Technical Notes: a bee venom; /antag permitted but consider also ANTIVENINS; do not confuse with drug Apamide ( = METHAMPHETAMINE)