 |
Apoptosis - Drug effects
Research News and Information
Definition of 'Apoptosis'One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. |
Sunday, November 22, 2009
p38SJ, a novel DINGG protein protects neuronal cells from alcohol induced injury and death.
29 Nov 2009 
Ethanol induces neuronal cell injury and death by dysregulating several signaling events that are controlled, in part, by activation of MAPK/ERK1/2 and/or inactivation of its corresponding phosphatase, PP1. Recently, we have purified a novel protein ... Read more...
Brain-derived neurotrophic factor protects cementoblasts from serum starvation-induced cell death.
29 Nov 2009 Our previous studies have shown that brain-derived neurotrophic factor (BDNF) enhances bone/cementum-related protein gene expression through the TrkB-c-Raf-ERK1/2-Elk-1 signaling pathway in cementoblasts, which play a critical role in the ... Read more...
Ceramide metabolism determines glioma cell resistance to chemotherapy.
29 Nov 2009 Tumor cell resistance to chemotherapy constitutes a major problem in the treatment of malignant tumors. We here investigated the role of ceramide metabolism for the resistance of glioma cells to treatment with the chemotherapeutic drug, gemcitabine. ... Read more...
Latest indexed articles for 'Apoptosis - Drug effects'
These are the very latest articles for this heading:
- p38SJ, a novel DINGG protein protects neuronal cells from alcohol induced injury and death. 29 Nov 2009
- Brain-derived neurotrophic factor protects cementoblasts from serum starvation-induced cell death. 29 Nov 2009
- Ceramide metabolism determines glioma cell resistance to chemotherapy. 29 Nov 2009
- Caffeic acid phenethyl ester, an active component of honeybee propolis attenuates osteoclastogenesis and bone resorption via the suppression of RANKL-induced NF-kappaB and NFAT activity. 29 Nov 2009
- Saurolactam inhibits osteoclast differentiation and stimulates apoptosis of mature osteoclasts. 29 Nov 2009
- Growth inhibition of bovine pulmonary artery smooth muscle cells following long-term heparin treatment. 29 Nov 2009
- Sphingosine kinase 1 inhibition sensitizes hormone-resistant prostate cancer to docetaxel. 29 Nov 2009
- Restriction of cisplatin induction of acute apoptosis to a subpopulation of cells in a three-dimensional carcinoma culture model. 13 Nov 2009
- Fisetin, a natural flavonoid, targets chemoresistant human pancreatic cancer AsPC-1 cells through DR3-mediated inhibition of NF-kappaB. 13 Nov 2009
- Minocycline inhibition of photoreceptor degeneration. 30 Oct 2009
- Attenuation of subarachnoid hemorrhage-induced apoptotic cell death with 17 beta-estradiol. Laboratory investigation. 30 Oct 2009
- Diallyl trisulfide-induced apoptosis in human cancer cells is linked to checkpoint kinase 1-mediated mitotic arrest. 30 Oct 2009
- Role of p75 neurotrophin receptor in isoflurane-mediated neuronal changes.
30 Oct 2009 - The role of KATP channels on propofol preconditioning in a cellular model of renal ischemia-reperfusion. 30 Oct 2009
- Genistein and resveratrol, alone and in combination, suppress prostate cancer in SV-40 tag rats. 30 Oct 2009
- Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model. 30 Oct 2009
- Heat-shock pretreatment inhibits sorbitol-induced apoptosis in K562, U937 and HeLa cells. 30 Oct 2009
- Leptin attenuates hypoxia/reoxygenation-induced activation of the intrinsic pathway of apoptosis in rat H9c2 cells. 30 Oct 2009
- Galactosyl derivative of N(omega)-nitro-L-arginine: study of antiproliferative activity on human thyroid follicular carcinoma cells. 30 Oct 2009
- Calpain inhibitors prevent p38 MAPK activation and germ cell apoptosis after heat stress in pubertal rat testes. 30 Oct 2009
See a longer list of these articles.
Technical information about 'Apoptosis'
Definition: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Descriptor UI: D017209
Alternative terms: Apoptosis; Programmed Cell Death, Type I; Apoptosis, Intrinsic Pathway; Apoptoses, Intrinsic Pathway; Intrinsic Pathway Apoptoses; Intrinsic Pathway Apoptosis; Apoptosis, Extrinsic Pathway; Apoptoses, Extrinsic Pathway; Extrinsic Pathway Apoptoses; Extrinsic Pathway Apoptosis;
Related Mesh Headings: Necrosis; Caspases; In Situ Nick-End Labeling; Cellular Apoptosis Susceptibility Protein; Genes, Transgenic, Suicide; Death Domain Receptor Signaling Adaptor Proteins; CARD Signaling Adaptor Proteins;
Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects;
Tree Number: G04.299.139.160;
History Note: 93
Technical Notes: do not confuse with NECROSIS, pathological cell death; unspecified probably goes here; PROGRAMMED CELL DEATH, TYPE II see AUTOPHAGY is also available