Apoptosis - Physiology
Research News and Information

Sunday, November 22, 2009

p38 Mitogen-activated protein kinase and hematologic malignancies.

30 Oct 2009 CONTEXT: p38 mitogen-activated protein kinase (MAPK) signaling has been implicated in responses ranging from apoptosis to cell cycle, induction of expression of cytokine genes, and differentiation. This plethora of activators conveys the complexity ... Read more...

Evaluation of cell surface expression of phosphatidylserine in ovarian carcinoma effusions using the annexin-V/7-AAD assay: clinical relevance and comparison with other apoptosis parameters.

30 Oct 2009 Phosphatidylserine cell surface exposure during apoptosis can be detected by its binding to the protein annexin-V. We investigated annexin-V expression in 76 ovarian carcinoma effusions using flow cytometry. Results were analyzed for association ... Read more...

Proteasome inhibition modulates kinase activation in neural cells: relevance to ubiquitination, ribosomes, and survival.

30 Oct 2009 In this study we examined whether established signal transduction cascades, p44/42 mitogen-activated protein kinase (ERK1/2) and Jun N-terminal kinases (JNK) pathways, are altered in N2a neural cells in response to proteasome inhibition. ... Read more...

Latest indexed articles for 'Apoptosis - Physiology'

These are the very latest articles for this heading:

• Radiation-induced sequelae measured by means of lymphocyte apoptosis: importance of certain single nucleotide polymorphisms: in regard to Schnarr et al. (Int J Radiat Oncol Biol Phys 2009). 13 Nov 2009
• p38 Mitogen-activated protein kinase and hematologic malignancies. 30 Oct 2009
• Evaluation of cell surface expression of phosphatidylserine in ovarian carcinoma effusions using the annexin-V/7-AAD assay: clinical relevance and comparison with other apoptosis parameters. 30 Oct 2009
• Proteasome inhibition modulates kinase activation in neural cells: relevance to ubiquitination, ribosomes, and survival. 30 Oct 2009
• The small heat shock protein Hsp27 protects cortical neurons against the toxic effects of beta-amyloid peptide. 30 Oct 2009
• Oxidative stress disrupts oligodendrocyte maturation. 30 Oct 2009
• Contribution of Kv channel subunits to glutamate-induced apoptosis in cultured rat hippocampal neurons. 30 Oct 2009
• Neural grafts in Huntington's disease: viability after 10 years. 30 Oct 2009
• Comparison of ACINUS, caspase-3, and TUNEL as apoptotic markers in determination of tumor growth rates of clinically localized prostate cancer using image analysis. 30 Oct 2009
• FLIP-mediated autophagy regulation in cell death control. 16 Oct 2009
• Cell death. 13 Oct 2009
• Tudor staphylococcal nuclease is an evolutionarily conserved component of the programmed cell death degradome. 9 Oct 2009
• Persistent measles virus infection of mouse neural cells lacking known human entry receptors. 29 Sep 2009
• Potential role of Notch1 signaling pathway in laryngeal squamous cell carcinoma cell line Hep-2 involving proliferation inhibition, cell cycle arrest, cell apoptosis, and cell migration. 29 Sep 2009
• Ninein-like protein is overexpressed in head and neck squamous cell carcinoma and contributes to cancer growth and resistance to apoptosis. 29 Sep 2009
• An essential role of the HIF-1alpha-c-Myc axis in malignant progression. 29 Sep 2009
• Role of purinergic receptor in alpha fodrin degradation in Par C5 cells. 29 Sep 2009
• Amphiregulin is a factor for resistance of glioma cells to cannabinoid-induced apoptosis. 29 Sep 2009
• Nerve growth factor attenuates proliferation of astrocytes via the p75 neurotrophin receptor. 29 Sep 2009
• The liver's dance with death: two Bcl-2 guardian proteins from the abyss. 29 Sep 2009

See a longer list of these articles.

Technical information about 'Apoptosis'

Definition: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.

Descriptor UI: D017209

Alternative terms: Apoptosis; Programmed Cell Death, Type I; Apoptosis, Intrinsic Pathway; Apoptoses, Intrinsic Pathway; Intrinsic Pathway Apoptoses; Intrinsic Pathway Apoptosis; Apoptosis, Extrinsic Pathway; Apoptoses, Extrinsic Pathway; Extrinsic Pathway Apoptoses; Extrinsic Pathway Apoptosis;

Related Mesh Headings: Necrosis; Caspases; In Situ Nick-End Labeling; Cellular Apoptosis Susceptibility Protein; Genes, Transgenic, Suicide; Death Domain Receptor Signaling Adaptor Proteins; CARD Signaling Adaptor Proteins;

Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects;

Tree Number: G04.299.139.160;

History Note: 93

Technical Notes: do not confuse with NECROSIS, pathological cell death; unspecified probably goes here; PROGRAMMED CELL DEATH, TYPE II see AUTOPHAGY is also available