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Apoptosis
Research News and Information
Definition of 'Apoptosis'One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. |
Saturday, November 21, 2009
p38SJ, a novel DINGG protein protects neuronal cells from alcohol induced injury and death.
29 Nov 2009 
Ethanol induces neuronal cell injury and death by dysregulating several signaling events that are controlled, in part, by activation of MAPK/ERK1/2 and/or inactivation of its corresponding phosphatase, PP1. Recently, we have purified a novel protein ... Read more...
Brain-derived neurotrophic factor protects cementoblasts from serum starvation-induced cell death.
29 Nov 2009 Our previous studies have shown that brain-derived neurotrophic factor (BDNF) enhances bone/cementum-related protein gene expression through the TrkB-c-Raf-ERK1/2-Elk-1 signaling pathway in cementoblasts, which play a critical role in the ... Read more...
Ceramide metabolism determines glioma cell resistance to chemotherapy.
29 Nov 2009 Tumor cell resistance to chemotherapy constitutes a major problem in the treatment of malignant tumors. We here investigated the role of ceramide metabolism for the resistance of glioma cells to treatment with the chemotherapeutic drug, gemcitabine. ... Read more...
Latest indexed articles for 'Apoptosis'
These are the very latest articles for this heading:
- p38SJ, a novel DINGG protein protects neuronal cells from alcohol induced injury and death. 29 Nov 2009
- Brain-derived neurotrophic factor protects cementoblasts from serum starvation-induced cell death. 29 Nov 2009
- Ceramide metabolism determines glioma cell resistance to chemotherapy. 29 Nov 2009
- Caffeic acid phenethyl ester, an active component of honeybee propolis attenuates osteoclastogenesis and bone resorption via the suppression of RANKL-induced NF-kappaB and NFAT activity. 29 Nov 2009
- Saurolactam inhibits osteoclast differentiation and stimulates apoptosis of mature osteoclasts. 29 Nov 2009
- Growth inhibition of bovine pulmonary artery smooth muscle cells following long-term heparin treatment. 29 Nov 2009
- Protein kinase C alpha-dependent signaling mediates endometrial cancer cell growth and tumorigenesis. 29 Nov 2009
- Cell cycle-related kinase supports ovarian carcinoma cell proliferation via regulation of cyclin D1 and is a predictor of outcome in patients with ovarian carcinoma. 29 Nov 2009
- RhoB induces apoptosis via direct interaction with TNFAIP1 in HeLa cells. 29 Nov 2009
- Activity of tyrosine kinase inhibitor Dasatinib in neuroblastoma cells in vitro and in orthotopic mouse model. 29 Nov 2009
- Id-1 promotes tumorigenicity and metastasis of human esophageal cancer cells through activation of PI3K/AKT signaling pathway. 29 Nov 2009
- Antagonism of chemokine receptor CXCR3 inhibits osteosarcoma metastasis to lungs. 29 Nov 2009
- Sphingosine kinase 1 inhibition sensitizes hormone-resistant prostate cancer to docetaxel. 29 Nov 2009
- Radiation-induced sequelae measured by means of lymphocyte apoptosis: importance of certain single nucleotide polymorphisms: in regard to Schnarr et al. (Int J Radiat Oncol Biol Phys 2009).
13 Nov 2009 - The reduction of cell death and proliferation by p27(Kip1) minimizes DNA damage in an experimental model of genotoxicity. 13 Nov 2009
- Mre11 inhibition by oncolytic adenovirus associates with autophagy and underlies synergy with ionizing radiation. 13 Nov 2009
- Restriction of cisplatin induction of acute apoptosis to a subpopulation of cells in a three-dimensional carcinoma culture model. 13 Nov 2009
- Fisetin, a natural flavonoid, targets chemoresistant human pancreatic cancer AsPC-1 cells through DR3-mediated inhibition of NF-kappaB. 13 Nov 2009
- Intrinsic resistance to the MEK1/2 inhibitor AZD6244 (ARRY-142886) is associated with weak ERK1/2 signalling and/or strong PI3K signalling in colorectal cancer cell lines. 13 Nov 2009
- Annexin A5 directly interacts with amyloidogenic proteins and reduces their toxicity. 8 Nov 2009
See a longer list of these articles.
Technical information about 'Apoptosis'
Definition: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Descriptor UI: D017209
Alternative terms: Apoptosis; Programmed Cell Death, Type I; Apoptosis, Intrinsic Pathway; Apoptoses, Intrinsic Pathway; Intrinsic Pathway Apoptoses; Intrinsic Pathway Apoptosis; Apoptosis, Extrinsic Pathway; Apoptoses, Extrinsic Pathway; Extrinsic Pathway Apoptoses; Extrinsic Pathway Apoptosis;
Related Mesh Headings: Necrosis; Caspases; In Situ Nick-End Labeling; Cellular Apoptosis Susceptibility Protein; Genes, Transgenic, Suicide; Death Domain Receptor Signaling Adaptor Proteins; CARD Signaling Adaptor Proteins;
Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects;
Tree Number: G04.299.139.160;
History Note: 93
Technical Notes: do not confuse with NECROSIS, pathological cell death; unspecified probably goes here; PROGRAMMED CELL DEATH, TYPE II see AUTOPHAGY is also available