Apoptosis - Research News and Information

Thursday, January 08, 2009

The dietary bioflavonoid, quercetin, selectively induces apoptosis of prostate cancer cells by down-regulating the expression of heat shock protein 90.

29 Nov 2008 BACKGROUND: Human and animal studies have suggested that diet-derived flavonoids, in particular quercetin may play a beneficial role by preventing or inhibiting oncogenesis, but the underlying mechanism remains unclear. The aim of this study is to ... Read more...

Calpain-mediated androgen receptor breakdown in apoptotic prostate cancer cells.

29 Nov 2008 Since androgen receptor (AR) plays an important role in prostate cancer development and progression, androgen-ablation has been the frontline therapy for treatment of advanced prostate cancer even though it is rarely curative. A curative strategy ... Read more...

Ferritin and FasL (CD95L) mediate density dependent apoptosis in primary rat hepatocytes.

29 Nov 2008 Based on a recent description of an apoptosis stimulating property for hepatocyte derived isoferritins, this investigation demonstrates that ferritin, released in vitro from hepatocytes substantially contributes to density dependent apoptosis in ... Read more...

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Latest indexed articles for 'Apoptosis'

These are the very latest articles for this heading:

• The dietary bioflavonoid, quercetin, selectively induces apoptosis of prostate cancer cells by down-regulating the expression of heat shock protein 90. 29 Nov 2008
• Calpain-mediated androgen receptor breakdown in apoptotic prostate cancer cells. 29 Nov 2008
• Ferritin and FasL (CD95L) mediate density dependent apoptosis in primary rat hepatocytes. 29 Nov 2008
• Long-term assessment of prostate cancer progression free survival: evaluation of pathological parameters, nuclear shape and molecular biomarkers of pathogenesis. 29 Nov 2008
• Fatty acid synthase inhibition with Orlistat promotes apoptosis and reduces cell growth and lymph node metastasis in a mouse melanoma model. 29 Nov 2008
• NF-kappaB2/p52 enhances androgen-independent growth of human LNCaP cells via protection from apoptotic cell death and cell cycle arrest induced by androgen-deprivation. 29 Nov 2008
• Short hairpin RNA targeting c-FLIP sensitizes human cervical adenocarcinoma Hela cells to chemotherapy and radiotherapy. 26 Nov 2008
• ApoG2, a novel inhibitor of antiapoptotic Bcl-2 family proteins, induces apoptosis and suppresses tumor growth in nasopharyngeal carcinoma xenografts. 13 Nov 2008
• Antiproliferative effects of AVN944, a novel inosine 5-monophosphate dehydrogenase inhibitor, in prostate cancer cells. 13 Nov 2008
• Targeting the methionine cycle for melanoma therapy with 3-O-(3,4,5-trimethoxybenzoyl)-(-)-epicatechin. 13 Nov 2008
• Identification of the regions of the HPV 5 E6 protein involved in Bak degradation and inhibition of apoptosis. 13 Nov 2008
• Susceptibility of pRb-deficient epidermis to chemical skin carcinogenesis is dependent on the p107 allele dosage. 30 Oct 2008
• Initiation of caspase-independent death in mouse mesangial cells by Cd2+: involvement of p38 kinase and CaMK-II. 30 Oct 2008
• Peripheral nerve pericytes originating from the blood-nerve barrier expresses tight junctional molecules and transporters as barrier-forming cells. 30 Oct 2008
• Epidermal growth factor receptor regulates osteoclast differentiation and survival through cross-talking with RANK signaling. 30 Oct 2008
• Detailing the role of Bax translocation, cytochrome c release, and perinuclear clustering of the mitochondria in the killing of HeLa cells by TNF. 30 Oct 2008
• Distinct roles of the three Akt isoforms in lactogenic differentiation and involution. 30 Oct 2008
• Mitotic catastrophe and apoptosis induced by docetaxel in hormone-refractory prostate cancer cells. 30 Oct 2008
• PML/RARalpha fusion protein mediates the unique sensitivity to arsenic cytotoxicity in acute promyelocytic leukemia cells: Mechanisms involve the impairment of cAMP signaling and the aberrant regulation of NADPH oxidase. 30 Oct 2008
• Intracellular death platform steps-in: targeting prostate tumors via endoplasmic reticulum (ER) apoptosis. 30 Oct 2008

See a longer list of these articles.

Technical information about 'Apoptosis'

Definition: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.

Descriptor UI: D017209

Alternative terms: Apoptosis; Programmed Cell Death, Type I; Apoptosis, Intrinsic Pathway; Apoptoses, Intrinsic Pathway; Intrinsic Pathway Apoptoses; Intrinsic Pathway Apoptosis; Apoptosis, Extrinsic Pathway; Apoptoses, Extrinsic Pathway; Extrinsic Pathway Apoptoses; Extrinsic Pathway Apoptosis;

Related Mesh Headings: Necrosis; Caspases; In Situ Nick-End Labeling; Cellular Apoptosis Susceptibility Protein; Genes, Transgenic, Suicide; Death Domain Receptor Signaling Adaptor Proteins; CARD Signaling Adaptor Proteins;

Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects;

Tree Number: G04.299.139.160;

History Note: 93

Technical Notes: do not confuse with NECROSIS, pathological cell death; unspecified probably goes here; PROGRAMMED CELL DEATH, TYPE II see AUTOPHAGY is also available