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Area Under Curve
Research News and Information
Definition of 'Area Under Curve'A statistical means of summarizing information from a series of measurements on one individual. It is frequently used in clinical pharmacology where the AUC from serum levels can be interpreted as the total uptake of whatever has been administered. As a plot of the concentration of a drug against time, after a single dose of medicine, producing a standard shape curve, it is a means of comparing the bioavailability of the same drug made by different companies. (From Winslade, Dictionary of Clinical Research, 1992) |
Saturday, November 21, 2009
16 Dec 2009 
This longitudinal study assessed the influence of post-transplant clinical and therapeutic variables in 50 kidney transplant recipients aged 2-19 yr receiving a triple immunosuppressive regimen consisting of cyclosporine microemulsion (CsA), ... Read more...
Sex affects the steady-state pharmacokinetics of primaquine but not doxycycline in healthy subjects.
30 Oct 2009 We evaluated whether sex affects the steady-state pharmacokinetics of the antimalarial drugs, primaquine and doxycycline, in healthy subjects. Seventeen male and 17 female healthy Vietnamese subjects were administered 30 mg (base) of primaquine ... Read more...
12 Oct 2009 Inhibitor kappaB kinase (IKK) regulates the activity of the transcription factor nuclear factor-kappa B that normally protects neurons against excitotoxicity. Constitutively active IKK is enriched at axon initial segments and nodes of Ranvier (NR). ... Read more...
Latest indexed articles for 'Area Under Curve'
These are the very latest articles for this heading:
- Longitudinal evaluation of mycophenolic acid pharmacokinetics in pediatric kidney transplant recipients. The role of post-transplant clinical and therapeutic variables. 16 Dec 2009
- Sex affects the steady-state pharmacokinetics of primaquine but not doxycycline in healthy subjects. 30 Oct 2009
- Inhibitor kappaB Kinase beta deficiency in primary nociceptive neurons increases TRP channel sensitivity. 12 Oct 2009
- Cold pressor stress impairs performance on working memory tasks requiring executive functions in healthy young men. 29 Sep 2009
- CYP2C19 genotype-based (R)-warfarin disposition assessment: some views on data analysis.
29 Sep 2009 - Two sampling time profiles for the abbreviated estimation of mycophenolic acid area under the curve in adult renal transplant recipients treated with mycophenolate mofetil and concomitant tacrolimus. 29 Sep 2009
- Protein profiling of pleural effusions to identify malignant pleural mesothelioma using SELDI-TOF MS. 29 Sep 2009
- Bioequivalence study of low-dose diclofenac potassium tablet formulations. 29 Sep 2009
- Bioequivalence study of two meloxicam tablet formulations after single-dose administration in healthy Thai male volunteers. 29 Sep 2009
- Comparative bioavailability of two formulations of sibutramine. 29 Sep 2009
- No impact of age on dose-adjusted pharmacokinetics of tacrolimus, mycophenolic acid and prednisolone 1 month after renal transplantation. 29 Sep 2009
- Pharmacokinetics of moxifloxacin in cerebrospinal fluid and plasma in patients with tuberculous meningitis. 29 Sep 2009
- Pharmacokinetic profiles of artesunate after single intravenous doses at 0.5, 1, 2, 4, and 8 mg/kg in healthy volunteers: a phase I study. 29 Sep 2009
- Why eicosanoids could represent a new class of tocolytics on uterine activity in pregnant women. 29 Sep 2009
- Quantitative trait loci mapping for adult-plant resistance to powdery mildew in Chinese wheat cultivar Bainong 64. 29 Sep 2009
- Mapping a barbiturate withdrawal locus to a 0.44 Mb interval and analysis of a novel null mutant identify a role for Kcnj9 (GIRK3) in withdrawal from pentobarbital, zolpidem, and ethanol. 14 Sep 2009
- Assessment of the performance of the Stanford Online Calculator for the prediction of nonsentinel lymph node metastasis in sentinel lymph node-positive breast cancer patients. 13 Sep 2009
- Proposed diagnostic criteria for obstructive meibomian gland dysfunction. 8 Sep 2009
- Minimum endotoxin concentration causing inflammation in the anterior segment of rabbit eyes. 6 Sep 2009
- The role of cervical Electrical Impedance Spectroscopy in the prediction of the course and outcome of induced labour. 31 Aug 2009
See a longer list of these articles.
Technical information about 'Area Under Curve'
Definition: A statistical means of summarizing information from a series of measurements on one individual. It is frequently used in clinical pharmacology where the AUC from serum levels can be interpreted as the total uptake of whatever has been administered. As a plot of the concentration of a drug against time, after a single dose of medicine, producing a standard shape curve, it is a means of comparing the bioavailability of the same drug made by different companies. (From Winslade, Dictionary of Clinical Research, 1992)
Descriptor UI: D019540
Alternative terms: Area Under Curve; Area Under Curves; Curve, Area Under; Curves, Area Under; Under Curve, Area; Under Curves, Area; AUC;
Tree Number: E05.318.740.200; G03.787.101; G07.690.725.064; N06.850.520.830.200;
History Note: 97
Technical Notes: a measure of drug bioavailability after a single dose; DF: note short X ref