Area Under Curve - Research News and Information

Thursday, January 08, 2009

Consumption of fructose-sweetened beverages for 10 weeks increases postprandial triacylglycerol and apolipoprotein-B concentrations in overweight and obese women.

30 Oct 2008 Fructose consumption in the USA has increased over the past three decades. During this time, obesity, insulin resistance and the metabolic syndrome have also increased in prevalence. While diets high in fructose have been shown to promote insulin ... Read more...

Immunological monitoring of calcineurin inhibitors for predicting cytomegalovirus infection in kidney transplant recipients.

25 Oct 2008 BACKGROUND: The short-term results of kidney transplantation are mainly attributed to the use of calcineurin inhibitors (CNI). However, opportunistic infections and cytomegalovirus (CMV) infections remain frequent and occur in the case of ... Read more...

Effect of inflammation on kidney function and pharmacokinetics of COX-2 selective nonsteroidal anti-inflammatory drugs rofecoxib and meloxicam.

29 Sep 2008 Chronic arthritis adversely affects glomerular function and nonsteroidal anti-inflammatory drugs (NSAIDs) reduce electrolyte urinary excretion. In addition, both acute and chronic inflammations may alter clearance of drugs. We studied (a) the ... Read more...

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Latest indexed articles for 'Area Under Curve'

These are the very latest articles for this heading:

• Consumption of fructose-sweetened beverages for 10 weeks increases postprandial triacylglycerol and apolipoprotein-B concentrations in overweight and obese women. 30 Oct 2008
• Immunological monitoring of calcineurin inhibitors for predicting cytomegalovirus infection in kidney transplant recipients. 25 Oct 2008
• Effect of inflammation on kidney function and pharmacokinetics of COX-2 selective nonsteroidal anti-inflammatory drugs rofecoxib and meloxicam. 29 Sep 2008
• Bioavailability of clarithromycin cyclodextrin ternary complexes upon oral administration to healthy beagle dogs. 29 Sep 2008
• Pharmacokinetics of budesonide and formoterol administered via a series of single-drug and combination inhalers: four open-label, randomized, crossover studies in healthy adults. 29 Sep 2008
• Gender differences in ondansetron pharmacokinetics in rats. 29 Sep 2008
• Clinical pharmacokinetics of isolated pelvic perfusion. 29 Sep 2008
• Prediction of fluid responsiveness in acute respiratory distress syndrome patients ventilated with low tidal volume and high positive end-expiratory pressure. 29 Sep 2008
• Poor predictive value of intraoperative real-time dosimetry for prostate seed brachytherapy. 29 Sep 2008
• Soluble ST2 plasma concentrations predict 1-year mortality in acutely dyspneic emergency department patients with pulmonary disease. 29 Sep 2008
• Response to editorial: animal models for nephrogenic systemic fibrosis. 29 Sep 2008
• Insulin-stimulated release of D-chiro-inositol-containing inositolphosphoglycan mediator correlates with insulin sensitivity in women with polycystic ovary syndrome. 29 Sep 2008
• Reproducibility of postprandial lipemia tests and validity of an abbreviated 4-hour test. 29 Sep 2008
• Assessment of treatment response and recurrence in esophageal carcinoma based on tumor length and standardized uptake value on positron emission tomography-computed tomography. 29 Sep 2008
• Dynamic contrast-enhanced magnetic resonance imaging pharmacodynamic biomarker study of sorafenib in metastatic renal carcinoma. 29 Sep 2008
• Relationship of "dose" of intracranial hypertension to outcome in severe traumatic brain injury. 29 Sep 2008
• Extended release dosage form of glipizide: development and validation of a level A in vitro-in vivo correlation. 29 Sep 2008
• Oral bioavailability of etoposide after administration of a single dose to tumor-bearing dogs. 29 Sep 2008
• Pharmacokinetics of the antimalarial drug piperaquine in healthy Vietnamese subjects. 29 Sep 2008
• Manipulation of lipid bioaccessibility of almond seeds influences postprandial lipemia in healthy human subjects. 29 Sep 2008

See a longer list of these articles.

Technical information about 'Area Under Curve'

Definition: A statistical means of summarizing information from a series of measurements on one individual. It is frequently used in clinical pharmacology where the AUC from serum levels can be interpreted as the total uptake of whatever has been administered. As a plot of the concentration of a drug against time, after a single dose of medicine, producing a standard shape curve, it is a means of comparing the bioavailability of the same drug made by different companies. (From Winslade, Dictionary of Clinical Research, 1992)

Descriptor UI: D019540

Alternative terms: Area Under Curve; Area Under Curves; Curve, Area Under; Curves, Area Under; Under Curve, Area; Under Curves, Area; AUC;

Tree Number: E05.318.740.200; G03.787.101; G07.690.725.064; N06.850.520.830.200;

History Note: 97

Technical Notes: a measure of drug bioavailability after a single dose; DF: note short X ref