Aromatase Inhibitors - Pharmacology
Research News and Information

Sunday, November 22, 2009

Chronic exposure to anabolic androgenic steroids alters neuronal function in the mammalian forebrain via androgen receptor- and estrogen receptor-mediated mechanisms.

5 Oct 2009 Anabolic androgenic steroids (AAS) can promote detrimental effects on social behaviors for which GABA type A (GABA(A)) receptor-mediated circuits in the forebrain play a critical role. While all AAS bind to androgen receptors (AR), they may also be ... Read more...

Long-term potentiation in the rat medial vestibular nuclei depends on locally synthesized 17beta-estradiol.

24 Aug 2009 In male rat brainstem slices, we investigated the involvement of locally synthesized 17beta-estradiol (E(2)) in the induction in the medial vestibular nucleus (MVN) of long-term potentiation (LTP) by high-frequency stimulation (HFS) of the primary ... Read more...

Cholesterol-promoted synaptogenesis requires the conversion of cholesterol to estradiol in the hippocampus.

30 Jul 2009 Cholesterol of glial origin promotes synaptogenesis (Mauch et al., (2001) Science 294:1354-1357). Because in the hippocampus local estradiol synthesis is essential for synaptogenesis, we addressed the question of whether cholesterol-promoted synapse ... Read more...

Latest indexed articles for 'Aromatase Inhibitors - Pharmacology'

These are the very latest articles for this heading:

• Chronic exposure to anabolic androgenic steroids alters neuronal function in the mammalian forebrain via androgen receptor- and estrogen receptor-mediated mechanisms. 5 Oct 2009
• Tamoxifen, antidepressants, and CYP2D6: the conundrum continues. 29 Sep 2009
• Long-term potentiation in the rat medial vestibular nuclei depends on locally synthesized 17beta-estradiol. 24 Aug 2009
• Cholesterol-promoted synaptogenesis requires the conversion of cholesterol to estradiol in the hippocampus. 30 Jul 2009
• Effect of aromatase inhibitors on lipid metabolism, inflammatory response and antioxidant balance in patients with breast carcinoma. 30 Jul 2009
• Metformin inhibits aromatase via an extracellular signal-regulated kinase-mediated pathway. 30 Jun 2009
• [Aromatase inhibitors: can these agents improve skeletal growth?] 29 Jun 2009
• Aromatase: the enzyme and its inhibition. 29 Jun 2009
• Sex hormones, acting on the TERT gene, increase telomerase activity in human primary hematopoietic cells. 24 Jun 2009
• Aromatase inactivation by 2-substituted derivatives of the suicide substrate androsta-1,4-diene-3,17-dione. 7 Jun 2009
• Expression of the K303R estrogen receptor-alpha breast cancer mutation induces resistance to an aromatase inhibitor via addiction to the PI3K/Akt kinase pathway. 30 May 2009
• In vitro kinetic properties of the Thr201Met variant of human aromatase gene CYP19A1: functional responses to substrate and product inhibition and enzyme inhibitors. 24 May 2009
• An efficient steroid pharmacophore-based strategy to identify new aromatase inhibitors. 17 May 2009
• Androgen- and estrogen-independent regulation of copulatory behavior following castration in male B6D2F1 mice. 16 May 2009
• The vascular endothelial growth factor receptor inhibitor PTK787/ZK222584 inhibits aromatase. 10 May 2009
• Alfacalcidol prevents aromatase inhibitor (Letrozole)-induced bone mineral loss in young growing female rats. 4 May 2009
• Sustained effect of the aromatase inhibitors anastrozole and letrozole on endometrial thickness in patients with endometrial hyperplasia and endometrial carcinoma. 29 Apr 2009
• Does postmenopausal estrogen use confer neuroprotection? 26 Apr 2009
• Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities. 7 Apr 2009
• Effects of aromatase inhibitors and different doses of testosterone on gonadotropins in one year old male Atlantic salmon (Salmo salar). 31 Mar 2009

See a longer list of these articles.

Technical information about 'Aromatase Inhibitors'

Definition: Compounds that inhibit AROMATASE in order to reduce production of estrogenic steroid hormones.

Registry Number: 0

Descriptor UI: D047072

Alternative terms: Aromatase Inhibitors; Inhibitors, Aromatase;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D27.505.519.389.099;

History Note: 2005