Arrestins - Deficiency
Research News and Information

Monday, November 23, 2009

Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression.

26 May 2009 Understanding the physiopathology of affective disorders and their treatment relies on the availability of experimental models that accurately mimic aspects of the disease. Here we describe a mouse model of an anxiety/depressive-like state induced ... Read more...

Beta-arrestin 2 is required for the induction and strengthening of integrin-mediated leukocyte adhesion during CXCR2-driven extravasation.

6 May 2009 Leukocyte extravasation involves interdependent signaling pathways underlying the complex dynamics of firm adhesion, crawling, and diapedesis. While signal transduction by agonist-bound chemokine receptors plays a central role in the above ... Read more...

Beta-Arrestin2 regulates RANKL and ephrins gene expression in response to bone remodeling in mice.

29 Apr 2009 PTH-stimulated intracellular signaling is regulated by the cytoplasmic adaptor molecule beta-arrestin. We reported that the response of cancellous bone to intermittent PTH is reduced in beta-arrestin2(-/-) mice and suggested that beta-arrestins ... Read more...

Latest indexed articles for 'Arrestins - Deficiency'

These are the very latest articles for this heading:

• Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression. 26 May 2009
• Beta-arrestin 2 is required for the induction and strengthening of integrin-mediated leukocyte adhesion during CXCR2-driven extravasation. 6 May 2009
• Beta-Arrestin2 regulates RANKL and ephrins gene expression in response to bone remodeling in mice. 29 Apr 2009
• Two distinct mechanisms mediate acute mu-opioid receptor desensitization in native neurons. 9 Mar 2009
• Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance. 24 Feb 2009
• Targeting of beta-arrestin2 to the centrosome and primary cilium: role in cell proliferation control. 12 Nov 2008
• Arrestin 3 mediates endocytosis of CCR7 following ligation of CCL19 but not CCL21. 29 Sep 2008
• Depletion of beta-arrestin-2 promotes tumor growth and angiogenesis in a murine model of lung cancer. 13 Apr 2008
• Modulation of voluntary ethanol consumption by beta-arrestin 2. 24 Mar 2008
• Beta-arrestins specifically constrain beta2-adrenergic receptor signaling and function in airway smooth muscle. 10 Mar 2008
• Agonist-directed signaling of the serotonin 2A receptor depends on beta-arrestin-2 interactions in vivo. 12 Jan 2008
• The role of beta-arrestins in the formyl peptide receptor-like 1 internalization and signaling. 27 May 2007
• Beta-arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2. 9 May 2007
• Differential effects of beta-arrestins on the internalization, desensitization and ERK1/2 activation downstream of protease activated receptor-2. 16 Apr 2007
• Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling. 23 Dec 2005
• A requirement for membrane cholesterol in the beta-arrestin- and clathrin-dependent endocytosis of LPA1 lysophosphatidic acid receptors. 30 Oct 2005
• Altered CXCR2 signaling in beta-arrestin-2-deficient mouse models. 13 Oct 2005
• Induction of delta-opioid receptor function in the midbrain after chronic morphine treatment. 21 Mar 2005
• G protein-coupled receptor kinase function is essential for chemosensation in C. elegans. 25 May 2004
• Enhanced rewarding properties of morphine, but not cocaine, in beta(arrestin)-2 knock-out mice. 10 Nov 2003

See a longer list of these articles.

Technical information about 'Arrestins'

Definition: Regulatory proteins that down-regulate phosphorylated G-protein membrane receptors, including rod and cone photoreceptors and adrenergic receptors.

Registry Number: 0

Descriptor UI: D019390

Alternative terms: Arrestins;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.776.306.090; D12.776.543.090;

History Note: 97

Technical Notes: regulatory proteins; do not confuse with ARRESTIN