Arrestins - Metabolism
Research News and Information

Monday, November 23, 2009

Endosomal deubiquitinating enzymes control ubiquitination and down-regulation of protease-activated receptor 2.

12 Aug 2009 The E3 ubiquitin ligase c-Cbl ubiquitinates the G protein-coupled receptor protease-activated receptor 2 (PAR(2)), which is required for postendocytic sorting of activated receptors to lysosomes, where degradation terminates signaling. The ... Read more...

Arrestin2/clathrin interaction is regulated by key N- and C-terminal regions in arrestin2.

2 Aug 2009 The interaction of nonvisual arrestins with clathrin is an important step in mediating the endocytosis of cell surface receptors. Previous studies have shown that mutation of the clathrin-binding box in arrestin leads to severe defects in ... Read more...

C5a- and ASP-mediated C5L2 activation, endocytosis and recycling are lost in S323I-C5L2 mutation.

14 Jul 2009 C5L2, a G-protein-coupled receptor (GPCR), has been identified as an ASP (C3adesArg) and C5a receptor. Controversy exists regarding both ligand binding and functionality. ASP activation of C5L2 is proposed to regulate fat storage. C5L2 is also ... Read more...

Latest indexed articles for 'Arrestins - Metabolism'

These are the very latest articles for this heading:

• Endosomal deubiquitinating enzymes control ubiquitination and down-regulation of protease-activated receptor 2. 12 Aug 2009
• Arrestin2/clathrin interaction is regulated by key N- and C-terminal regions in arrestin2. 2 Aug 2009
• C5a- and ASP-mediated C5L2 activation, endocytosis and recycling are lost in S323I-C5L2 mutation. 14 Jul 2009
• The prostaglandin receptor EP2 activates multiple signaling pathways and beta-arrestin1 complex formation during mouse skin papilloma development. 6 Jul 2009
• Functional selectivity of natural and synthetic prostaglandin EP4 receptor ligands. 5 Jul 2009
• Pharmacological characterization of a selective agonist for bombesin receptor subtype-3. 2 Jul 2009
• Arrestin3 mediates D(2) dopamine receptor internalization. 29 Jun 2009
• Endosomal endothelin-converting enzyme-1: a regulator of beta-arrestin-dependent ERK signaling. 14 Jun 2009
• beta-Arrestin mediates beta1-adrenergic receptor-epidermal growth factor receptor interaction and downstream signaling. 7 Jun 2009
• Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands. 31 May 2009
• Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression. 26 May 2009
• Convergent pathways link the endothelin A receptor to the beta-catenin: the beta-arrestin connection. 23 May 2009
• Identification of betaArrestin2 as a corepressor of androgen receptor signaling in prostate cancer. 18 May 2009
• [Effect of fentanyl on expression of mu-receptor and beta-arrestin 2 in periaqueductal gray of rats tolerant to morphine] 17 May 2009
• Inhibition of EGF-induced ERK/MAP kinase-mediated astrocyte proliferation by mu opioids: integration of G protein and beta-arrestin 2-dependent pathways. 6 May 2009
• The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization. 5 May 2009
• Dephosphorylation of beta-arrestin 1 in glioblastomas. 29 Apr 2009
• Beta-Arrestin2 regulates RANKL and ephrins gene expression in response to bone remodeling in mice. 29 Apr 2009
• The type III TGF-beta receptor regulates epithelial and cancer cell migration through beta-arrestin2-mediated activation of Cdc42. 29 Apr 2009
• Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5. 14 Apr 2009

See a longer list of these articles.

Technical information about 'Arrestins'

Definition: Regulatory proteins that down-regulate phosphorylated G-protein membrane receptors, including rod and cone photoreceptors and adrenergic receptors.

Registry Number: 0

Descriptor UI: D019390

Alternative terms: Arrestins;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.776.306.090; D12.776.543.090;

History Note: 97

Technical Notes: regulatory proteins; do not confuse with ARRESTIN