Arrestins
Research News and Information

Sunday, November 22, 2009

Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways.

29 Sep 2009 Arrestins were identified as mediators of G protein-coupled receptor (GPCR) desensitization and endocytosis. However, it is now clear that they scaffold many intracellular signaling networks to modulate the strength and duration of signaling by ... Read more...

Endosomal deubiquitinating enzymes control ubiquitination and down-regulation of protease-activated receptor 2.

12 Aug 2009 The E3 ubiquitin ligase c-Cbl ubiquitinates the G protein-coupled receptor protease-activated receptor 2 (PAR(2)), which is required for postendocytic sorting of activated receptors to lysosomes, where degradation terminates signaling. The ... Read more...

Beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling.

4 Aug 2009 G protein-coupled receptors (GPCRs) have been found to trigger G protein-independent signalling. However, the regulation of G protein-independent pathways, especially their desensitization, is poorly characterized. Here, we show that the G ... Read more...

Latest indexed articles for 'Arrestins'

These are the very latest articles for this heading:

• Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways. 29 Sep 2009
• Endosomal deubiquitinating enzymes control ubiquitination and down-regulation of protease-activated receptor 2. 12 Aug 2009
• Beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling. 4 Aug 2009
• Arrestin2/clathrin interaction is regulated by key N- and C-terminal regions in arrestin2. 2 Aug 2009
• C5a- and ASP-mediated C5L2 activation, endocytosis and recycling are lost in S323I-C5L2 mutation. 14 Jul 2009
• The prostaglandin receptor EP2 activates multiple signaling pathways and beta-arrestin1 complex formation during mouse skin papilloma development. 6 Jul 2009
• Functional selectivity of natural and synthetic prostaglandin EP4 receptor ligands. 5 Jul 2009
• Pharmacological characterization of a selective agonist for bombesin receptor subtype-3. 2 Jul 2009
• Arrestin3 mediates D(2) dopamine receptor internalization. 29 Jun 2009
• Endosomal endothelin-converting enzyme-1: a regulator of beta-arrestin-dependent ERK signaling. 14 Jun 2009
• beta-Arrestin mediates beta1-adrenergic receptor-epidermal growth factor receptor interaction and downstream signaling. 7 Jun 2009
• Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands. 31 May 2009
• Nicotine sensitization and analysis of brain-derived neurotrophic factor in adolescent beta-arrestin-2 knockout mice. 30 May 2009
• Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression. 26 May 2009
• HIV-1 gp120 primes lymphocytes for opioid-induced, beta-arrestin 2-dependent apoptosis. 25 May 2009
• Convergent pathways link the endothelin A receptor to the beta-catenin: the beta-arrestin connection. 23 May 2009
• Identification of betaArrestin2 as a corepressor of androgen receptor signaling in prostate cancer. 18 May 2009
• [Effect of fentanyl on expression of mu-receptor and beta-arrestin 2 in periaqueductal gray of rats tolerant to morphine] 17 May 2009
• Beta-arrestin 2 is required for the induction and strengthening of integrin-mediated leukocyte adhesion during CXCR2-driven extravasation. 6 May 2009
• Inhibition of EGF-induced ERK/MAP kinase-mediated astrocyte proliferation by mu opioids: integration of G protein and beta-arrestin 2-dependent pathways. 6 May 2009

See a longer list of these articles.

Technical information about 'Arrestins'

Definition: Regulatory proteins that down-regulate phosphorylated G-protein membrane receptors, including rod and cone photoreceptors and adrenergic receptors.

Registry Number: 0

Descriptor UI: D019390

Alternative terms: Arrestins;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.776.306.090; D12.776.543.090;

History Note: 97

Technical Notes: regulatory proteins; do not confuse with ARRESTIN