Arylamine N-Acetyltransferase - Genetics
Research News and Information

Tuesday, March 16, 2010

Genetic variations in xenobiotic metabolic pathway genes, personal hair dye use, and risk of non-Hodgkin lymphoma.

10 Oct 2009 From 1996 to 2000, the authors conducted a population-based case-control study among Connecticut women to test the hypothesis that genetic variation in xenobiotic metabolic pathway genes modifies the relation between hair dye use and risk of ... Read more...

Environmental factors promoting bladder cancer.

30 Aug 2009 PURPOSE OF REVIEW: To understand the molecular mechanisms of bladder carcinogenesis in relation to environmental carcinogens in order to provide a given population with a preventive value of bladder cancer. RECENT FINDINGS: Cigarette smoking, ... Read more...

Involvement of N-acetyltransferase human in the cytotoxic activity of 5-fluorouracil.

30 Aug 2009 N-acetyltransferase human (NATH) participates in a posttranslational modification of the proteins and has been reported to play a role in apoptosis. In this study, the involvement of NATH in the cytotoxic action of 5-fluorouracil (5-FU) in human ... Read more...

Latest indexed articles for 'Arylamine N-Acetyltransferase - Genetics'

These are the very latest articles for this heading:

• Genetic variations in xenobiotic metabolic pathway genes, personal hair dye use, and risk of non-Hodgkin lymphoma. 10 Oct 2009
• Environmental factors promoting bladder cancer. 30 Aug 2009
• Involvement of N-acetyltransferase human in the cytotoxic activity of 5-fluorouracil. 30 Aug 2009
• Impact of interaction of polymorphic forms of p53 codon 72 and N-acetylation gene (NAT2) on the risk of lung cancer in the North Indian population. 30 Aug 2009
• Somatic alterations, metabolizing genes and smoking in rectal cancer. 29 Jun 2009
• Effects of dietary factors and the NAT2 acetylator status on gastric cancer in Koreans. 29 Jun 2009
• Effects of NAT2 polymorphism on SASP pharmacokinetics in Chinese population. 24 Jun 2009
• Dietary intake of vegetables and fruits and the modification effects of GSTM1 and NAT2 genotypes on bladder cancer risk. 21 Jun 2009
• Meat and heterocyclic amine intake, smoking, NAT1 and NAT2 polymorphisms, and colorectal cancer risk in the multiethnic cohort study. 21 Jun 2009
• N-acetyltransferase 2 (NAT2) polymorphism in patients with atopic asthma. 2 Jun 2009
• Cigarette smoking, N-acetyltransferase 2 polymorphisms and systemic lupus erythematosus in a Japanese population. 30 May 2009
• Proteomics analyses reveal the evolutionary conservation and divergence of N-terminal acetyltransferases from yeast and humans. 4 May 2009
• GSTM1 and NAT2 polymorphisms and colon, lung and bladder cancer risk: a case-control study. 29 Apr 2009
• Genetic polymorphisms in CYP1A1, CYP1B1, COMT, GSTP1 and NAT2 genes and association with bladder cancer risk in a French cohort. 29 Apr 2009
• Do smoking and polymorphisms in xenobiotic metabolizing enzymes affect the histological stage and grade of bladder tumors? 29 Apr 2009
• Combined effect of smoking and inherited polymorphisms in arylamine N-acetyltransferase 2, glutathione S-transferases M1 and T1 on bladder cancer in a Tunisian population. 13 Apr 2009
• The impact of NAT2 acetylator genotype on mutagenesis and DNA adducts from 2-amino-9H-pyrido[2,3-b]indole. 30 Mar 2009
• Aromatic DNA adducts and polymorphisms in metabolic genes in healthy adults: findings from the EPIC-Spain cohort. 21 Mar 2009
• Association of NAT2, GSTM1, GSTT1, CYP2A6, and CYP2A13 gene polymorphisms with susceptibility and clinicopathologic characteristics of bladder cancer in Central China. 18 Mar 2009
• Analysis association between mitochondrial genome instability and xenobiotic metabolizing genes in human breast cancer. 4 Mar 2009

See a longer list of these articles.

Technical information about 'Arylamine N-Acetyltransferase'

Definition: An enzyme that catalyzes the transfer of acetyl groups from ACETYL-COA to arylamines. It can also catalyze acetyl transfer between arylamines without COENZYME A and has a wide specificity for aromatic amines, including SEROTONIN. However, arylamine N-acetyltransferase should not be confused with the enzyme ARYLALKYLAMINE N-ACETYLTRANSFERASE which is also referred to as SEROTONIN ACETYLTRANSFERASE.

Chemical name: Acetyl-CoA:arylamine N-acetyltransferase

Registry Number: EC 2.3.1.5

Descriptor UI: D001191

Alternative terms: Arylamine N-Acetyltransferase; Arylamine N Acetyltransferase; N-Acetyltransferase, Arylamine; Arylamine Acetyltransferases; Acetyltransferases, Arylamine; Arylamine Acetylases; Acetylases, Arylamine; Acetyl-CoA Arylamine N-Acetyltransferase; Acetyl CoA Arylamine N Acetyltransferase; Arylamine N-Acetyltransferase, Acetyl-CoA; N-Acetyltransferase, Acetyl-CoA Arylamine; Arylamine Acetylase; Acetylase, Arylamine;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D08.811.913.050.313;

History Note: 98(80)

Technical Notes: do not confuse with ARYLALKYLAMINE N-ACETYLTRANSFERASE