Ascorbic Acid - Biosynthesis
Research News and Information

Monday, March 22, 2010

Beta-catenin regulates vitamin C biosynthesis and cell survival in murine liver.

16 Aug 2009 Because the Wnt/beta-catenin pathway plays multiple roles in liver pathobiology, it is critical to identify gene targets that mediate such diverse effects. Here we report a novel role of beta-catenin in controlling ascorbic acid biosynthesis in ... Read more...

Ascorbic acid conversion to erythroascorbic acid, mediated by ubiquitin.

May 2009 We recently identified a microbial conversion of L-ascorbic acid (AsA) to L-erythroascorbic acid (eAsA), a five-carbon analog of AsA. In this paper, we show that ubiquitin plays a crucial role in this process. Based on an assay that determined AsA ... Read more...

AMR1, an Arabidopsis gene that coordinately and negatively regulates the mannose/l-galactose ascorbic acid biosynthetic pathway.

22 Apr 2009 Ascorbic acid (AsA) biosynthesis in plants occurs through a complex, interconnected network with mannose (Man), myoinositol, and galacturonic acid as principal entry points. Regulation within and between pathways in the network is largely ... Read more...

Latest indexed articles for 'Ascorbic Acid - Biosynthesis'

These are the very latest articles for this heading:

• Beta-catenin regulates vitamin C biosynthesis and cell survival in murine liver. 16 Aug 2009
• Ascorbic acid conversion to erythroascorbic acid, mediated by ubiquitin. May 2009
• AMR1, an Arabidopsis gene that coordinately and negatively regulates the mannose/l-galactose ascorbic acid biosynthetic pathway. 22 Apr 2009
• Galactonolactone dehydrogenase requires a redox-sensitive thiol for optimal production of vitamin C. 13 Apr 2009
• VTC4 is a bifunctional enzyme that affects myoinositol and ascorbate biosynthesis in plants. 30 Mar 2009
• L-Ascorbate biosynthesis in peach: cloning of six L-galactose pathway-related genes and their expression during peach fruit development. 10 Feb 2009
• Gene expression studies in kiwifruit and gene over-expression in Arabidopsis indicates that GDP-L-galactose guanyltransferase is a major control point of vitamin C biosynthesis. 4 Jan 2009
• Expression profiling of ascorbic acid-related genes during tomato fruit development and ripening and in response to stress conditions. 4 Jan 2009
• Myoinositol oxygenase controls the level of myoinositol in Arabidopsis, but does not increase ascorbic acid. 15 Dec 2008
• Control of ascorbic acid synthesis and accumulation and glutathione by the incident light red/far red ratio in Phaseolus vulgaris leaves. 4 Dec 2008
• Restoration of vitamin C synthesis in transgenic Gulo-/- mice by helper-dependent adenovirus-based expression of gulonolactone oxidase. 29 Nov 2008
• Gene expression of ascorbic acid biosynthesis related enzymes of the Smirnoff-Wheeler pathway in acerola (Malpighia glabra). 23 Oct 2008
• Conversion of L-galactono-1,4-lactone to L-ascorbate is regulated by the photosynthetic electron transport chain in Arabidopsis. 5 Oct 2008
• L-Ascorbate biosynthesis in higher plants: the role of VTC2. 25 Sep 2008
• The pathway via D-galacturonate/L-galactonate is significant for ascorbate biosynthesis in Euglena gracilis: identification and functional characterization of aldonolactonase. 7 Sep 2008
• An expression analysis of the ascorbate biosynthesis enzyme VTC2. 29 May 2008
• Heterologous production of secondary metabolites as pharmaceuticals in Saccharomyces cerevisiae. 28 May 2008
• A second GDP-L-galactose phosphorylase in arabidopsis en route to vitamin C. Covalent intermediate and substrate requirements for the conserved reaction. 5 May 2008
• Elevated oxidative stress and sensorimotor deficits but normal cognition in mice that cannot synthesize ascorbic acid. 5 May 2008
• Recent advances in ascorbate biosynthesis and the physiological significance of ascorbate peroxidase in photosynthesizing organisms. 5 May 2008

See a longer list of these articles.

Technical information about 'Ascorbic Acid'

Definition: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.

Chemical name: L-Ascorbic acid

Registry Number: 50-81-7

Descriptor UI: D001205

Alternative terms: Ascorbic Acid; Acid, Ascorbic; Vitamin C; L-Ascorbic Acid; Acid, L-Ascorbic; L Ascorbic Acid; Sodium Ascorbate; Ascorbate, Sodium; Ascorbic Acid, Monosodium Salt; Magnesium Ascorbicum; Magnorbin; Ferrous Ascorbate; Ascorbate, Ferrous; Hybrin;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Antioxidants; Vitamins;

Tree Number: D02.241.081.844.107; D02.241.511.902.107; D09.811.100;

History Note: /therapeutic use was ASCORBIC ACID, THERAPEUTIC 1965

Technical Notes: /defic = ASCORBIC ACID DEFICIENCY or SCURVY