Aspartate Aminotransferases - Metabolism
Research News and Information

Monday, November 23, 2009

Effects of fenofibrate on plasma and hepatic transaminase activities and hepatic transaminase gene expression in rats.

29 Sep 2009 Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels are widely used as sensitive markers of possible tissue damage, particularly liver toxicity. Lipid-lowering drugs, such as fibrates, slightly increase serum ... Read more...

Glutamate metabolic pathways and retinal function.

20 Aug 2009 Glutamate is a major neurotransmitter in the CNS but is also a key metabolite intimately coupled to amino acid production/degradation. We consider the effect of inhibition of two key glutamate metabolic enzymes: glutamine synthetase (GS) and ... Read more...

Protective effects of thiopronin against isoniazid-induced hepatotoxicity in rats.

11 Aug 2009 Isoniazid is a widely used drug for the treatment of tuberculosis, but hepatotoxicity is a major concern during treatment. Thiopronin contains an SH-group and is generally considered an antioxidant. The aim of the present study was to investigate ... Read more...

Latest indexed articles for 'Aspartate Aminotransferases - Metabolism'

These are the very latest articles for this heading:

• Effects of fenofibrate on plasma and hepatic transaminase activities and hepatic transaminase gene expression in rats. 29 Sep 2009
• Glutamate metabolic pathways and retinal function. 20 Aug 2009
• Protective effects of thiopronin against isoniazid-induced hepatotoxicity in rats. 11 Aug 2009
• (-)-Epigallocatechin gallate prevents carbon tetrachloride-induced rat hepatic fibrosis by inhibiting the expression of the PDGFRbeta and IGF-1R. 28 Jul 2009
• Long-term monitoring of patients with infantile-onset Pompe disease on enzyme replacement therapy using a urinary glucose tetrasaccharide biomarker. 29 Jun 2009
• Prolonged QTc interval in children and young adults with sickle cell disease at steady state. 29 Jun 2009
• Hepatic injury induced by carbon dioxide pneumoperitoneum in experimental rats. 26 Jun 2009
• Zizyphus spina-christi protects against carbon tetrachloride-induced liver fibrosis in rats. 11 Jun 2009
• Experimental infection of Balb/c nude mice with Hepatitis E virus. 11 Jun 2009
• Flaxseed oil attenuates nonalcoholic fatty liver of hyperlipidemic hamsters. 8 Jun 2009
• Effect of infrared laser irradiation on amino acid neurotransmitters in an epileptic animal model induced by pilocarpine. 30 May 2009
• Elevated serum interferon-alpha activity in juvenile dermatomyositis: associations with disease activity at diagnosis and after thirty-six months of therapy. 30 May 2009
• Two types of unsafe drinker judged to have metabolic syndrome: typical metabolic syndrome or alcohol-related syndrome? 30 May 2009
• Cardioprotective effect of salvianolic acid A on isoproterenol-induced myocardial infarction in rats. 11 May 2009
• Perforin expression in peripheral blood lymphatic cells of patients subjected to laparoscopic or open cholecystectomy. 5 May 2009
• In vivo acute toxicity of titanium dioxide nanoparticles to mice after intraperitioneal injection. 29 Apr 2009
• Evaluation of creatine kinase (CK) and aspartate aminotransferase (AST) activities after laparoscopic or conventional ovariectomy in queens. 29 Apr 2009
• Uridine-5'-triphosphate protects against hepatic- ischemic/reperfusion injury in mice. 25 Apr 2009
• Non-alcoholic steatohepatitis with normal aminotransferase values. 19 Apr 2009
• Hepatoprotective effects of an anthocyanin fraction from purple-fleshed sweet potato against acetaminophen-induced liver damage in mice. 30 Mar 2009

See a longer list of these articles.

Technical information about 'Aspartate Aminotransferases'

Definition: Enzymes of the transferase class that catalyze the conversion of L-aspartate and 2-ketoglutarate to oxaloacetate and L-glutamate. EC 2.6.1.1.

Chemical name: L-Aspartate:2-oxoglutarate aminotransaminase

Registry Number: EC 2.6.1.1

Descriptor UI: D001219

Alternative terms: Aspartate Aminotransferases; Aminotransferases, Aspartate; Aspartate Apoaminotransferase; Apoaminotransferase, Aspartate; Aspartate Transaminase; Transaminase, Aspartate; Glutamic-Oxaloacetic Transaminase; Glutamic Oxaloacetic Transaminase; Transaminase, Glutamic-Oxaloacetic; L-Aspartate-2-Oxoglutarate Aminotransferase; Aminotransferase, L-Aspartate-2-Oxoglutarate; L Aspartate 2 Oxoglutarate Aminotransferase; Aspartate Aminotransferase; Aminotransferase, Aspartate; Glutamate-Aspartate Transaminase; Glutamate Aspartate Transaminase; Transaminase, Glutamate-Aspartate; SGOT; Serum Glutamic-Oxaloacetic Transaminase; Glutamic-Oxaloacetic Transaminase, Serum; Serum Glutamic Oxaloacetic Transaminase; Transaminase, Serum Glutamic-Oxaloacetic;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D08.811.913.477.700.225;

History Note: 2002(1963)

Technical Notes: note specifics