Astrocytes - Drug effects
Research News and Information

Monday, November 23, 2009

Propofol inhibits aquaporin 4 expression through a protein kinase C-dependent pathway in an astrocyte model of cerebral ischemia/reoxygenation.

30 Oct 2009 BACKGROUND: Aquaporin 4 (AQP4) plays a key role in maintaining water balance in the central nervous system, and its dysfunction may lead to brain edema. Previous studies have suggested that propofol may be involved in neuroprotection by preventing ... Read more...

Cognitive decline in Alzheimer's disease is associated with selective changes in calcineurin/NFAT signaling.

12 Oct 2009 Upon activation by calcineurin, the nuclear factor of activated T-cells (NFAT) translocates to the nucleus and guides the transcription of numerous molecules involved in inflammation and Ca(2+) dysregulation, both of which are prominent features of ... Read more...

GABA uptake-dependent Ca(2+) signaling in developing olfactory bulb astrocytes.

28 Sep 2009 We studied GABAergic signaling in astrocytes of olfactory bulb slices using confocal Ca(2+) imaging and two-photon Na(+) imaging. GABA evoked Ca(2+) transients in astrocytes that persisted in the presence of GABA(A) and GABA(B) receptor antagonists, ... Read more...

Latest indexed articles for 'Astrocytes - Drug effects'

These are the very latest articles for this heading:

• Propofol inhibits aquaporin 4 expression through a protein kinase C-dependent pathway in an astrocyte model of cerebral ischemia/reoxygenation. 30 Oct 2009
• Cognitive decline in Alzheimer's disease is associated with selective changes in calcineurin/NFAT signaling. 12 Oct 2009
• GABA uptake-dependent Ca(2+) signaling in developing olfactory bulb astrocytes. 28 Sep 2009
• Selective estrogen receptor modulators decrease reactive astrogliosis in the injured brain: effects of aging and prolonged depletion of ovarian hormones. 22 Sep 2009
• [ARTCEREB irrigation and perfusion solution for cerebrospinal surgery: pharmacological assessment using human astrocytes exposed to test solutions] 30 Aug 2009
• Oxidative injury triggers autophagy in astrocytes: the role of endogenous zinc. 30 Aug 2009
• The effect of cadmium on brain cells in culture. 30 Aug 2009
• Ca2+- and thromboxane-dependent distribution of MaxiK channels in cultured astrocytes: from microtubules to the plasma membrane. 30 Aug 2009
• Astrocytic dysfunction in epileptogenesis: consequence of altered potassium and glutamate homeostasis? 24 Aug 2009
• Activation of p-38alpha MAPK contributes to neuronal hyperexcitability in caudal regions remote from spinal cord injury. 18 Aug 2009
• Hydrostatic pressure-dependent changes in cyclic AMP signaling in optic nerve head astrocytes from Caucasian and African American donors. 18 Aug 2009
• Induction of Nrf2 and xCT are involved in the action of the neuroprotective antibiotic ceftriaxone in vitro. 16 Aug 2009
• Gap junction inhibitors modulate S100B secretion in astrocyte cultures and acute hippocampal slices. 13 Aug 2009
• Mechanism underlying apolipoprotein E (ApoE) isoform-dependent lipid efflux from neural cells in culture. 13 Aug 2009
• Protective Effects of the Essential Oil of Salvia fruticosa and Its Constituents on Astrocytic Susceptibility to Hydrogen Peroxide-Induced Cell Death. 10 Aug 2009
• Ischemia-related changes in naive and mutant forms of ubiquitin and neuroprotective effects of ubiquitin in the hippocampus following experimental transient ischemic damage. 5 Aug 2009
• Reactive oxygen species-induced cell death of rat primary astrocytes through mitochondria-mediated mechanism. 30 Jul 2009
• Developmental and post-injury cortical gliogenesis: a genetic fate-mapping study with Nestin-CreER mice. 30 Jul 2009
• CD38 regulation in activated astrocytes: implications for neuroinflammation and HIV-1 brain infection. 30 Jul 2009
• Corticospinal neurons respond differentially to neurotrophins and myelin-associated glycoprotein in vitro. 30 Jul 2009

See a longer list of these articles.

Technical information about 'Astrocytes'

Definition: A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from "star" cells) are irregularly shaped with many long processes, including those with "end feet" which form the glial (limiting) membrane and directly and indirectly contribute to the BLOOD-BRAIN BARRIER. They regulate the extracellular ionic and chemical environment, and "reactive astrocytes" (along with MICROGLIA) respond to injury.

Descriptor UI: D001253

Alternative terms: Astrocytes; Astrocyte; Astroglia; Astroglias;

Related Mesh Headings: Blood-Brain Barrier;

Allowable Qualifiers: classification; cytology; drug effects; enzymology; immunology; metabolism; microbiology; parasitology; pathology; physiology; radiation effects; radiography; radionuclide imaging; secretion; transplantation; ultrastructure; ultrasonography; chemistry; virology;

Tree Number: A08.637.200; A11.650.200;

Online Note: search NEUROGLIA 1966-74

History Note: 79(75); was see under NEUROGLIA 1963-78