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Atherosclerosis - Research News and Information
Thursday, January 08, 2009
Definition of 'Atherosclerosis'Thickening and loss of elasticity of the walls of medium and large muscular ARTERIES with lesions in the innermost layer of the artery (ARTERIAL INTIMA). This disease process of atherogenesis includes the retention of cholesterol-rich LIPOPROTEINS and their binding to PROTEOGLYCANS in the arterial intima, generation of proinflammatory molecules that recruit MACROPHAGES to the subendothelial space, formation of FOAM CELLS, and eventual calcification of the arterial wall. These arterial plaques (atheromas) contain CARBOHYDRATES; BLOOD; and CALCIUM. |
7 Nov 2008 
CONTEXT: Previous trials have investigated the effects of low-dose aspirin on primary prevention of cardiovascular events, but not in patients with type 2 diabetes. OBJECTIVE: To examine the efficacy of low-dose aspirin for the primary prevention ... Read more...
Inflammation at the molecular interface of atherogenesis: an anthropological journey.
30 Oct 2008 Despite the multifactorial nature of atherosclerosis, substantial evidence has established inflammation as an often surreptitious, yet critical and unifying driving force which promotes disease progression. To this end, research has defined ... Read more...
30 Oct 2008 OBJECTIVE: To examine the association between changes in waist-hip ratio (WHR), a measure of abdominal obesity, and age-related macular degeneration (AMD). METHODS: A total of 12 515 persons from a population-based cohort study, aged 45 to 64 years ... Read more...
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Latest indexed articles for 'Atherosclerosis'
These are the very latest articles for this heading:
- Low-dose aspirin for primary prevention of atherosclerotic events in patients with type 2 diabetes: a randomized controlled trial. 7 Nov 2008
- From systemic shotgun to site-specific nanoparticle-targeted delivery: a new paradigm for drug delivery.
30 Oct 2008 - Morphing the topography of atherosclerosis: an unexpected role for PECAM-1. 30 Oct 2008
- Antiinflammatory actions of HDL: a new insight. 30 Oct 2008
- Of mice and men: blowing away the cobwebs from the mechanism of action of niacin on HDL metabolism. 30 Oct 2008
- Chemokines in atherosclerosis, thrombosis, and vascular biology. 30 Oct 2008
- Inflammation at the molecular interface of atherogenesis: an anthropological journey. 30 Oct 2008
- Changes in abdominal obesity and age-related macular degeneration: the Atherosclerosis Risk in Communities Study. 30 Oct 2008
- Genetically elevated C-reactive protein and ischemic vascular disease. 28 Oct 2008
- Elevated C-reactive protein in atherosclerosis--chicken or egg? 28 Oct 2008
- Blood viscosity and hematocrit as risk factors for type 2 diabetes mellitus: the atherosclerosis risk in communities (ARIC) study.
15 Oct 2008 - CD40 ligand+ microparticles from human atherosclerotic plaques stimulate endothelial proliferation and angiogenesis a potential mechanism for intraplaque neovascularization. 12 Oct 2008
- Possible dual role of ubiquitin-proteasome system in the atherosclerotic plaque progression. 12 Oct 2008
- Structural determinants of MIF functions in CXCR2-mediated inflammatory and atherogenic leukocyte recruitment. 11 Oct 2008
- Diabetes-accelerated atherosclerosis and inflammation. 8 Oct 2008
- Regulation of the atheroma-enriched protein, SPRR3, in vascular smooth muscle cells through cyclic strain is dependent on integrin alpha1beta1/collagen interaction. 30 Sep 2008
- CD11c(+) dendritic cells maintain antigen processing, presentation capabilities, and CD4(+) T-cell priming efficacy under hypercholesterolemic conditions associated with atherosclerosis. 30 Sep 2008
- Polymeric particles conjugated with a ligand to VCAM-1 exhibit selective, avid, and focal adhesion to sites of atherosclerosis. 29 Sep 2008
- Clinical implications of the "personal" genome. 29 Sep 2008
- Is it LDL particle size or number that correlates with risk for cardiovascular disease? 29 Sep 2008
See a longer list of these articles.
Technical information about 'Atherosclerosis'
Definition: Thickening and loss of elasticity of the walls of medium and large muscular ARTERIES with lesions in the innermost layer of the artery (ARTERIAL INTIMA). This disease process of atherogenesis includes the retention of cholesterol-rich LIPOPROTEINS and their binding to PROTEOGLYCANS in the arterial intima, generation of proinflammatory molecules that recruit MACROPHAGES to the subendothelial space, formation of FOAM CELLS, and eventual calcification of the arterial wall. These arterial plaques (atheromas) contain CARBOHYDRATES; BLOOD; and CALCIUM.
Descriptor UI: D050197
Alternative terms: Atherosclerosis; Atheroscleroses; Fatty Streak, Arterial; Arterial Fatty Streak; Arterial Fatty Streaks; Fatty Streaks, Arterial; Streak, Arterial Fatty; Streaks, Arterial Fatty; Atheroma; Atheromas; Atherogenesis;
Related Mesh Headings: Chylomicron Remnants;
Allowable Qualifiers: blood; cerebrospinal fluid; chemically induced; classification; complications; congenital; diagnosis; diet therapy; drug therapy; economics; embryology; enzymology; ethnology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; radiotherapy; rehabilitation; surgery; therapy; urine; veterinary; ultrasonography; virology;
Tree Number: C14.907.137.126.307;
History Note: 2006; use ARTERIOSCLEROSIS 1963-2005