Autoimmunity - Research News and Information

Thursday, January 08, 2009

Tolerance without clonal expansion: self-antigen-expressing B cells program self-reactive T cells for future deletion.

13 Oct 2008 B cells have been shown in various animal models to induce immunological tolerance leading to reduced immune responses and protection from autoimmunity. We show that interaction of B cells with naive T cells results in T cell triggering accompanied ... Read more...

CTLA-4 control over Foxp3+ regulatory T cell function.

8 Oct 2008 Naturally occurring Foxp3+CD4+ regulatory T cells (Tregs) are essential for maintaining immunological self-tolerance and immune homeostasis. Here, we show that a specific deficiency of cytotoxic T lymphocyte antigen 4 (CTLA-4) in Tregs results in ... Read more...

Gene gun-mediated DNA vaccination enhances antigen-specific immunotherapy at a late preclinical stage of type 1 diabetes in nonobese diabetic mice.

29 Sep 2008 Type 1 diabetes (T1D) is characterized by the T cell mediated destruction of the insulin-producing beta cells. Antigen-specific immunotherapies are used to selectively tolerize beta cell-specific pathogenic T cells either directly, or indirectly ... Read more...

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Latest indexed articles for 'Autoimmunity'

These are the very latest articles for this heading:

• Tolerance without clonal expansion: self-antigen-expressing B cells program self-reactive T cells for future deletion. 13 Oct 2008
• Immunology. Regulating suppression. 8 Oct 2008
• CTLA-4 control over Foxp3+ regulatory T cell function. 8 Oct 2008
• Gene gun-mediated DNA vaccination enhances antigen-specific immunotherapy at a late preclinical stage of type 1 diabetes in nonobese diabetic mice. 29 Sep 2008
• Regulatory T cells in rheumatoid arthritis. 29 Sep 2008
• [Molecular mechanisms and diagnosis of autoimmune hemolytic anemia] 29 Sep 2008
• Type I interferon in the induction or exacerbation of dermatomyositis: what this observation tells us about the naturally occurring disease. 29 Sep 2008
• Tolerance to self: which cells kill? 28 Sep 2008
• Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger. 17 Sep 2008
• T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance. 9 Sep 2008
• GM-CSF mediates autoimmunity by enhancing IL-6-dependent Th17 cell development and survival. 6 Sep 2008
• Autoreactive B-cell elimination by pathogenic IgG specific for the same antigen: implications for peripheral tolerance. 31 Aug 2008
• STAT4: genetics, mechanisms, and implications for autoimmunity. 30 Aug 2008
• Nucleic acid-mediated inflammatory diseases. 30 Aug 2008
• Heparin-induced thrombocytopenia: some working hypotheses on pathogenesis, diagnostic strategies and treatment. 30 Aug 2008
• IL-17 and the Th17 lineage in systemic lupus erythematosus. 30 Aug 2008
• The role of innate immunity in autoimmune tissue injury. 30 Aug 2008
• Are pediatric autoimmune diseases primarily genetic diseases? 30 Aug 2008
• Cytokines, Graves' disease, and thyroid-associated ophthalmopathy. 30 Aug 2008
• High prevalence of thyroid autoimmunity in Apulian patients with autoimmune polyglandular syndrome type 1. 30 Aug 2008

See a longer list of these articles.

Technical information about 'Autoimmunity'

Definition: Process whereby the immune system reacts against the body's own tissues. Autoimmunity may produce or be caused by AUTOIMMUNE DISEASES.

Descriptor UI: D015551

Alternative terms: Autoimmunity; Autoimmunities; Autoimmune Response; Autoimmune Responses;

Related Mesh Headings: Autoantibodies; Autoimmune Diseases;

Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects;

Tree Number: G12.450.192;

History Note: 90