Autophagy - Research News and Information

Thursday, January 08, 2009

Therapeutic starvation and autophagy in prostate cancer: a new paradigm for targeting metabolism in cancer therapy.

29 Nov 2008 BACKGROUND: Autophagy is a starvation induced cellular process of self-digestion that allows cells to degrade cytoplasmic contents. The understanding of autophagy, as either a mechanism of resistance to therapies that induce metabolic stress, or as ... Read more...

Nucleolar p19ARF, unlike mitochondrial smARF, is incapable of inducing p53-independent autophagy.

27 Oct 2008 ARF mRNA encodes two distinct proteins, the nucleolar p19(ARF), and a shorter mitochondrial isoform, named smARF. Inappropriate proliferative signals generated by proto-oncogenes, such as c-Myc and E2F1, can elevate both p19(ARF) and smARF ... Read more...

Dissecting autophagosome formation: the missing pieces.

27 Oct 2008 The formation of autophagosomes is the central part of the macroautophagy pathway. Little is known, however, about how the participants in this process affect the membrane dynamics at the phagophore assembly site (PAS). Recently, we demonstrated ... Read more...

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Latest indexed articles for 'Autophagy'

These are the very latest articles for this heading:

• Therapeutic starvation and autophagy in prostate cancer: a new paradigm for targeting metabolism in cancer therapy. 29 Nov 2008
• IFN-gamma and self-absorbed CD4+ T cells: a regulatory double negative. 30 Oct 2008
• Nucleolar p19ARF, unlike mitochondrial smARF, is incapable of inducing p53-independent autophagy. 27 Oct 2008
• Dissecting autophagosome formation: the missing pieces. 27 Oct 2008
• alpha-synuclein degradation by autophagic pathways: a potential key to Parkinson's disease pathogenesis. 24 Oct 2008
• Harpooning the Cvt complex to the phagophore assembly site. 22 Oct 2008
• Does bafilomycin A1 block the fusion of autophagosomes with lysosomes? 20 Oct 2008
• Autophagy induction by a natural ingredient of areca nut. 18 Oct 2008
• CCL2, survivin and autophagy: new links with implications in human cancer. 18 Oct 2008
• Qing Zhong: scoring a slam dunk on the autophagy court. 18 Oct 2008
• Chloroplasts are partially mobilized to the vacuole by autophagy. 16 Oct 2008
• Dissecting the localization and function of Atg18, Atg21 and Ygr223c. 16 Oct 2008
• Induction of autophagy via innate bacterial recognition. 16 Oct 2008
• Decreased neuronal autophagy in HIV dementia: a mechanism of indirect neurotoxicity. 16 Oct 2008
• Quantitative regulation of vesicle formation in yeast nonspecific autophagy. 13 Oct 2008
• Dynamics and function of PtdIns(3)P in autophagy. 12 Oct 2008
• Dual role of JNK1-mediated phosphorylation of Bcl-2 in autophagy and apoptosis regulation. 12 Oct 2008
• Beclin 1 bridges autophagy, apoptosis and differentiation. 12 Oct 2008
• Targeted therapy for the loss of von Hippel-Lindau in renal cell carcinoma: a novel molecule that induces autophagic cell death. 11 Oct 2008
• Autophagy following heat stress: the role of aging and protein nitration. 10 Oct 2008

See a longer list of these articles.

Technical information about 'Autophagy'

Definition: The segregation and degradation of damaged or unwanted cytoplasmic constituents by autophagic vacuoles (cytolysosomes) composed of LYSOSOMES containing cellular components in the process of digestion; it plays an important role in BIOLOGICAL METAMORPHOSIS of amphibians, in the removal of bone by osteoclasts, and in the degradation of normal cell components in nutritional deficiency states.

Descriptor UI: D001343

Alternative terms: Autophagy; Autophagies; Autophagocytosis; Autophagy, Cellular; Autophagies, Cellular; Cellular Autophagies; Cellular Autophagy; Programmed Cell Death, Type II; Autophagic Programmed Cell Death; Autophagic Cell Death; Autophagic Cell Deaths; Cell Death, Autophagic; Cell Deaths, Autophagic; Death, Autophagic Cell; Deaths, Autophagic Cell;

Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects; ethics;

Tree Number: G04.299.139.399; G04.299.482.350.091;

History Note: 2006(1979)

Technical Notes: programmed cell death unspecified probably = APOPTOSIS, but check text