Azathioprine
Research News and Information

Sunday, November 22, 2009

[56-year-old patient with leg paresis, pulmonary infiltrates, and eosinophilia--Case 08/2009]

19 Oct 2009 HISTORY AND ADMISSION FINDINGS: A 56-year-old woman presented with progressive dyspnea and polyneuropathia. Medical history revealed a bronchial asthma and hypertension. She was in a reduced general condition and had to be admitted to the intensive ... Read more...

Emerging treatments for complex perianal fistula in Crohn's disease.

12 Sep 2009 Complex perianal fistulas have a negative impact on the quality of life of sufferers and should be treated. Correct diagnosis, characterization and classification of the fistulas are essential to optimize treatment. Nevertheless, in the case of ... Read more...

Mutagenicity and potential carcinogenicity of thiopurine treatment in patients with inflammatory bowel disease.

23 Aug 2009 The thiopurines azathioprine and 6-mercaptopurine (6-MP) are effective immune modulators and cytotoxic agents extensively used in the treatment of autoimmune diseases, graft rejection, and cancer. There is compelling epidemiologic evidence that ... Read more...

Latest indexed articles for 'Azathioprine'

These are the very latest articles for this heading:

• [56-year-old patient with leg paresis, pulmonary infiltrates, and eosinophilia--Case 08/2009] 19 Oct 2009
• Emerging treatments for complex perianal fistula in Crohn's disease. 12 Sep 2009
• Crohn's disease, hepatosplenic T-cell lymphoma and no biological therapy: are we barking up the wrong tree? 30 Aug 2009
• Mutagenicity and potential carcinogenicity of thiopurine treatment in patients with inflammatory bowel disease. 23 Aug 2009
• Mycophenolate mofetil as second line immunosuppressant in Myasthenia gravis--a long-term prospective open-label study. 10 Aug 2009
• Intellectual property. Drug metabolite patents prompt legal battle. 5 Aug 2009
• Third cranial nerve palsy or pseudo 3rd nerve palsy of myasthenia gravis? A challenging diagnosis in systemic lupus erythematosus. 30 Jul 2009
• IBD: incidence of HSV and HPV with azathioprine. 30 Jul 2009
• Nodular malignant melanoma and multiple cutaneous neoplasms under immunosuppression with azathioprine. 30 Jul 2009
• Severe Legionella pneumophila pneumonia following infliximab therapy in a patient with Crohn's disease. 30 Jul 2009
• Use of azathioprine and 6MP in postoperative Crohn's: changing natural history or just along for the ride? 30 Jul 2009
• Transition from pemphigus foliaceus to bullous pemphigoid: intermolecular B-cell epitope spreading without IgG subclass shifting. 30 Jul 2009
• Perianal disease, small bowel disease, smoking, prior steroid or early azathioprine/biological therapy are predictors of disease behavior change in patients with Crohn's disease. 26 Jul 2009
• Membranous lupus nephritis in Chinese children--a case series and review of the literature. 20 Jul 2009
• [Headaches and aphasia in an immunocompromised patient] 6 Jul 2009
• Intravenous immunoglobulin as adjuvant therapy for Wegener's granulomatosis. 6 Jul 2009
• Evaluation of the genetic background of standard-immunosuppressant-related toxicity in a cohort of 200 paediatric renal allograft recipients--a retrospective study. 29 Jun 2009
• Experience with multiple stent implantations in primary antiphospholipid syndrome in childhood: a case report. 29 Jun 2009
• Impact of the heterozygous TPMT*1/*3C genotype on azathioprine-induced myelosuppression in kidney transplant recipients in Thailand. 29 Jun 2009
• Adverse reactions to azathioprine cannot be predicted by thiopurine S-methyltransferase genotype in Japanese patients with inflammatory bowel disease. 29 Jun 2009

See a longer list of these articles.

Technical information about 'Azathioprine'

Definition: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)

Chemical name: 1H-Purine, 6-((1-methyl-4-nitro-1H-imidazol-5-yl)thio)-

Registry Number: 446-86-6

Descriptor UI: D001379

Alternative terms: Azathioprine; Azothioprine; Azathioprine Sulfate; Azathioprine Sodium Salt; Imuran; Immuran; Imurel;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Antimetabolites; Antimetabolites, Antineoplastic; Immunosuppressive Agents; Antirheumatic Agents;

Tree Number: D02.886.759.111; D03.438.759.534.090; D13.570.900.111;

History Note: 66(64)