Baclofen - Research News and Information

Thursday, January 08, 2009

The impact of intrathecal baclofen on the natural history of scoliosis in cerebral palsy.

30 Aug 2008 BACKGROUND: Intrathecal baclofen (ITB) is an effective treatment of spasticity in patients with cerebral palsy. However, several recent reports have raised concerns that the treatment may be associated with a rapid progression of scoliosis. The ... Read more...

Indirect resolution of baclofen enantiomers from pharmaceutical dosage form by reversed-phase liquid chromatography after derivatization with Marfey's reagent and its structural variants.

30 Jul 2008 A high-performance liquid chromatographic (HPLC) method was developed for chiral assay of baclofen enantiomers in pharmaceutical formulations using an indirect approach. Baclofen enantiomers were derivatized with Marfey's reagent (FDNP-L-Ala-NH2) ... Read more...

5-(4-Chlorophenyl)-5,6-dihydro-1,3-oxazepin-7(4H)-one derivatives as lipophilic cyclic analogues of baclofen: design, synthesis, and neuropharmacological evaluation.

27 Jul 2008 In trials to preserve the pharmacological profile and improve the bioavailability via lipophilicity increment of baclofen 1 and searching for more potent and less toxic muscle relaxants and analgesics, nine substituted cyclic analogues of 1 were ... Read more...

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Latest indexed articles for 'Baclofen'

These are the very latest articles for this heading:

• The impact of intrathecal baclofen on the natural history of scoliosis in cerebral palsy. 30 Aug 2008
• Indirect resolution of baclofen enantiomers from pharmaceutical dosage form by reversed-phase liquid chromatography after derivatization with Marfey's reagent and its structural variants. 30 Jul 2008
• Satisfaction with intrathecal baclofen treatment in paediatric patients with progressive neurological disease. 30 Jul 2008
• 5-(4-Chlorophenyl)-5,6-dihydro-1,3-oxazepin-7(4H)-one derivatives as lipophilic cyclic analogues of baclofen: design, synthesis, and neuropharmacological evaluation. 27 Jul 2008
• The effects of chronic intraperitoneal administration of the GABA B receptor agonist baclofen on food intake in rats. 13 Jul 2008
• Retrograde GABA signaling adjusts sound localization by balancing excitation and inhibition in the brainstem. 8 Jul 2008
• GABA(B) receptor modulation of feedforward inhibition through hippocampal neurogliaform cells. 30 Jun 2008
• GabaB receptors activation in the NTS blocks the glycemic responses induced by carotid body receptor stimulation. 30 Jun 2008
• In vivo and in vitro ethanol exposure in prenatal rat brain: GABA(B) receptor modulation on dopamine D(1) receptor and protein kinase A. 29 Jun 2008
• [Intrathecal baclofen in generalised dystonia secondary to cerebral hypoxia] 29 Jun 2008
• Multiple functions of GABA A and GABA B receptors during pattern processing in the zebrafish olfactory bulb. 29 Jun 2008
• [Intrathecal baclofen therapy] 29 Jun 2008
• Activation of the GABA(A) receptor ameliorates the cochlear excitotoxicity caused by kainic acid in the guinea pig. 29 Jun 2008
• Experimental studies of potential analgesics for the treatment of chemotherapy-evoked painful peripheral neuropathies. 29 Jun 2008
• Plasticity of pre- and postsynaptic GABAB receptor function in the paraventricular nucleus in spontaneously hypertensive rats. 18 Jun 2008
• Life-threatening constipation induced by intrathecal baclofen therapy. 12 Jun 2008
• Regulation of cardiac sympathetic afferent reflex by GABA(A) and GABA(B) receptors in paraventricular nucleus in rats. 30 May 2008
• Formulation of controlled-release baclofen matrix tablets. II. Influence of some hydrophobic excipients on the release rate and in vitro evaluation. 22 May 2008
• Suppression of detrusor-sphincter dysynergia by GABA-receptor activation in the lumbosacral spinal cord in spinal cord-injured rats. 19 May 2008
• Renin and aldosterone but not the natriuretic peptide correlate with obsessive craving in medium-term abstinent alcohol-dependent patients: a longitudinal study. 14 May 2008

See a longer list of these articles.

Technical information about 'Baclofen'

Definition: A GAMMA-AMINOBUTYRIC ACID derivative that is a specific agonist at GABA-B receptors (RECEPTORS, GABA-B). It is used in the treatment of spasticity, especially that due to spinal cord damage. Its therapeutic effects result from actions at spinal and supraspinal sites, generally the reduction of excitatory transmission.

Chemical name: Benzenepropanoic acid, beta-(aminomethyl)-4-chloro-

Registry Number: 1134-47-0

Descriptor UI: D001418

Alternative terms: Baclofen; PCP-GABA; beta-(p-Chlorophenyl)-gamma-aminobutyric Acid; Chlorophenyl GABA; GABA, Chlorophenyl; Baclophen; beta-(Aminomethyl)-4-chlorobenzenepropanoic Acid; Nu-Baclo; Nu Baclo; NuBaclo; Nu-Pharm Brand of Baclofen; Baclofen Nu-Pharm Brand; Nu Pharm Brand of Baclofen; PMS-Baclofen; PMS Baclofen; PMSBaclofen; Pharmascience Brand of Baclofen; Baclofen Pharmascience Brand; Apo-Baclofen; Apo Baclofen; ApoBaclofen; Apotex Brand of Baclofen; Baclofen Apotex Brand; Atrofen; Athena Brand of Baclofen; Baclofen Athena Brand; Lebic; Isis Brand of Baclofen; Baclofen Isis Brand; Baclofen AWD; AWD, Baclofen; ASTA Medica Brand of Baclofen; Baclofène-Irex; Baclofène Irex; BaclofèneIrex; Irex Brand of Baclofen; Baclofen Irex Brand; Baclospas; Ashbourne Brand of Baclofen; Baclofen Ashbourne Brand; Clofen; Alphapharm Brand of Baclofen; Baclofen Alphapharm Brand; Gen-Baclofen; Gen Baclofen; GenBaclofen; Genpharm; Lioresal; Novartis Brand of Baclofen; Baclofen Novartis Brand; Medtronic Brand of Baclofen; Baclofen Medtronic Brand; Ciba-Geigy Brand of Baclofen; Baclofen Ciba-Geigy Brand; Ciba Geigy Brand of Baclofen; Liorésal; Ba-34,647; Ba34,647; CIBA-34,647-BA; CIBA34,647BA; Ba-34647; Ba34647;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Muscle Relaxants, Central; GABA Agonists;

Tree Number: D02.241.081.160.050.350.100;

History Note: 80(75); was see under AMINOBUTYRIC ACIDS 1975-79