Base Sequence - Research News and Information

Thursday, January 08, 2009

EGFR genetic heterogeneity of nonsmall cell lung cancers contributing to acquired gefitinib resistance.

29 Nov 2008 Gefitinib is dramatically effective for nonsmall cell lung cancers (NSCLCs) with activating mutations of the epidermal growth factor receptor (EGFR) gene, but these tumors eventually develop drug resistance, attributable to a secondary T790M ... Read more...

Alterations of 3p21.31 tumor suppressor genes in head and neck squamous cell carcinoma: Correlation with progression and prognosis.

29 Nov 2008 The aim of our study was to analyze the alterations of some candidate tumor suppressor genes (TSGs) viz. LIMD1, LTF, CDC25A, SCOTIN, RASSF1A and CACNA2D2 located in the chromosomal region 3p21.31 associated with the development of early dysplastic ... Read more...

Biophysical and biochemical characterization of a liposarcoma-derived recombinant MnSOD protein acting as an anticancer agent.

29 Nov 2008 A recombinant MnSOD (rMnSOD) synthesized by specific cDNA clones derived from a liposarcoma cell line was shown to have the same sequence as the wild-type MnSOD expressed in the human myeloid leukaemia cell line U937, except for the presence of the ... Read more...

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Latest indexed articles for 'Base Sequence'

These are the very latest articles for this heading:

• EGFR genetic heterogeneity of nonsmall cell lung cancers contributing to acquired gefitinib resistance. 29 Nov 2008
• Alterations of 3p21.31 tumor suppressor genes in head and neck squamous cell carcinoma: Correlation with progression and prognosis. 29 Nov 2008
• Biophysical and biochemical characterization of a liposarcoma-derived recombinant MnSOD protein acting as an anticancer agent. 29 Nov 2008
• An activating mutation in AKT1 in human prostate cancer. 29 Nov 2008
• KAI1/CD82 is a novel target of estrogen receptor-mediated gene repression and downregulated in primary human breast cancer. 13 Nov 2008
• MLH1 -93G>A promoter polymorphism and risk of mismatch repair deficient colorectal cancer. 13 Nov 2008
• Targeting the methionine cycle for melanoma therapy with 3-O-(3,4,5-trimethoxybenzoyl)-(-)-epicatechin. 13 Nov 2008
• Intratumoral rhIL-12 administration in head and neck squamous cell carcinoma patients induces B cell activation. 13 Nov 2008
• Promoter hypermethylation of CDH13 is a common, early event in human esophageal adenocarcinogenesis and correlates with clinical risk factors. 13 Nov 2008
• miR-296 regulates growth factor receptor overexpression in angiogenic endothelial cells. 2 Nov 2008
• Populations of p53 codon 270 CGT to TGT mutant cells in SKH-1 mouse skin tumors induced by simulated solar light. 30 Oct 2008
• Differences of the porcine amelogenin X and Y chromosome genes (AMELX and AMELY) and their application for sex determination in pigs. 30 Oct 2008
• Screening, identification, and functional analysis of three novel missense mutations in the TRADD gene in children with ALL and ALPS. 30 Oct 2008
• Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity. 30 Oct 2008
• Pleuro-pulmonary solitary fibrous tumors: a clinicopathologic, immunohistochemical, and molecular study of 88 cases confirming the prognostic value of de Perrot staging system and p53 expression, and evaluating the role of c-kit, BRAF, PDGFRs (alpha/beta), c-met, and EGFR. 30 Oct 2008
• Regulation of the mouse Treacher Collins syndrome homolog (Tcof1) promoter through differential repression of constitutive expression. 30 Oct 2008
• Emergence of Clostridium difficile infection due to a new hypervirulent strain, polymerase chain reaction ribotype 078. 30 Oct 2008
• Functional alterations of liver innate immunity of mice with aging in response to CpG-oligodeoxynucleotide. 30 Oct 2008
• Molecular analysis of the Penicillium marneffei glyceraldehyde-3-phosphate dehydrogenase-encoding gene (gpdA) and differential expression of gpdA and the isocitrate lyase-encoding gene (acuD) upon internalization by murine macrophages. 30 Oct 2008
• The potential pathogenicity of chlorhexidine-sensitive Acanthamoeba strains isolated from contact lens cases from asymptomatic individuals in Tenerife, Canary Islands, Spain. 30 Oct 2008

See a longer list of these articles.

Technical information about 'Base Sequence'

Definition: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

Descriptor UI: D001483

Alternative terms: Base Sequence; Base Sequences; Sequence, Base; Sequences, Base; Nucleotide Sequence; Nucleotide Sequences; Sequence, Nucleotide; Sequences, Nucleotide; RNA Sequence; RNA Sequences; Sequence, RNA; Sequences, RNA; DNA Sequence; Sequence, DNA; Sequences, DNA; DNA Sequences;

Allowable Qualifiers: drug effects; genetics; physiology; radiation effects;

Tree Number: G02.111.570.080; G05.360.080; L01.453.245.667.080;

History Note: 78(71); was see under BIOCHEMISTRY 1975-77

Technical Notes: IM general only; coord with specific nucleic acid; do not confuse with BASE COMPOSITION: comp = what components & how many, sequ = order in which arranged; for base sequencing, use SEQUENCE ANALYSIS, DNA or SEQUENCE ANALYSIS, RNA; when to index with MOLECULAR SEQUENCE DATA: see note there; DF: BASE SEQ