Basophils
Research News and Information

Tuesday, February 09, 2010

SHIP represses the generation of IL-3-induced M2 macrophages by inhibiting IL-4 production from basophils.

24 Aug 2009 There is a great deal of interest in determining what regulates the generation of classically activated (M1) vs alternatively activated (M2) macrophages (Mphis) because of the opposing effects that these two Mphi subsets have on tumor progression. ... Read more...

IL-33 activates unprimed murine basophils directly in vitro and induces their in vivo expansion indirectly by promoting hematopoietic growth factor production.

12 Aug 2009 IL-33, a new member of the IL-1 family, has been described as an important inducer of Th2 cytokines and mediator of inflammatory responses. In this study, we demonstrate that murine basophils sorted directly from the bone marrow, without prior ... Read more...

Basophils can directly present or cross-present antigen to CD8 lymphocytes and alter CD8 T cell differentiation into IL-10-producing phenotypes.

8 Aug 2009 There is increasing evidence suggesting that basophils play a critical role in developing Th2-type immunity both in vitro and in vivo. We previously reported that basophils cocultured with naive CD4 T cells stimulated with Ag promote the ... Read more...

Latest indexed articles for 'Basophils'

These are the very latest articles for this heading:

• Editorial: Basophil survival and immunomodulatory function are uniquely regulated by a novel MyD88-dependent pathway. 29 Sep 2009
• SHIP represses the generation of IL-3-induced M2 macrophages by inhibiting IL-4 production from basophils. 24 Aug 2009
• IL-33 activates unprimed murine basophils directly in vitro and induces their in vivo expansion indirectly by promoting hematopoietic growth factor production. 12 Aug 2009
• Basophils can directly present or cross-present antigen to CD8 lymphocytes and alter CD8 T cell differentiation into IL-10-producing phenotypes. 8 Aug 2009
• The basophil activation test in immediate-type drug allergy. 30 Jul 2009
• Haemopoietic processes in allergic disease: eosinophil/basophil development. 18 Jul 2009
• The non-specific lipid transfer protein, Ara h 9, is an important allergen in peanut. 14 Jul 2009
• Exploring the repertoire of IgE-binding self-antigens associated with atopic eczema. 7 Jul 2009
• STAT1 negatively regulates lung basophil IL-4 expression induced by respiratory syncytial virus infection. 6 Jul 2009
• Clinical efficacy and immune regulation with peanut oral immunotherapy. Jul 2009
• Basophil responsiveness in chronic urticaria. 29 Jun 2009
• New concepts of hive formation in cholinergic urticaria. 29 Jun 2009
• Basophils trump dendritic cells as APCs for T(H)2 responses. 29 Jun 2009
• Immunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell-stimulating programs in basophils. 26 Jun 2009
• Inhibitory effects of flavonoids isolated from Fragaria ananassa Duch on IgE-mediated degranulation in rat basophilic leukemia RBL-2H3. 25 Jun 2009
• Human innate immunosenescence: causes and consequences for immunity in old age. 19 Jun 2009
• A novel nanoparticulate adjuvant for immunotherapy with Lolium perenne. 19 Jun 2009
• The binding specificity and selective antagonism of vedolizumab, an anti-alpha4beta7 integrin therapeutic antibody in development for inflammatory bowel diseases. 7 Jun 2009
• Italian position paper on urticaria. Italian Board on Urticaria. 30 May 2009
• [An exciting new era of basophil research: newly discovered roles for basophils in acute and chronic allergic reactions] 30 May 2009

See a longer list of these articles.

Technical information about 'Basophils'

Definition: Granular leukocytes characterized by a relatively pale-staining, lobate nucleus and cytoplasm containing coarse dark-staining granules of variable size and stainable by basic dyes.

Descriptor UI: D001491

Alternative terms: Basophils; Basophil;

Allowable Qualifiers: classification; cytology; drug effects; enzymology; immunology; metabolism; microbiology; parasitology; pathology; physiology; radiation effects; radiography; radionuclide imaging; secretion; transplantation; ultrastructure; ultrasonography; chemistry; virology;

Tree Number: A11.118.637.415.120; A11.627.340.120; A15.145.229.637.415.120; A15.382.490.315.120;

Technical Notes: restrict to leukocytes: not for "basophilic" when referring only to staining ( = STAINING)