Benzazepines - Pharmacology
Research News and Information

Sunday, November 22, 2009

Indolobenzazepin-7-ones and 6-, 8-, and 9-membered ring derivatives as tubulin polymerization inhibitors: synthesis and structure--activity relationship studies.

6 Oct 2009 Several small weight indole derivatives (D-64131, D-24851, BPR0L075, BLF 61-3, and ATI derivatives) are potent tubulin polymerization inhibitors and show nanomolar antiproliferative activity. Among them, indolobenzazepin-7-ones were recently ... Read more...

Regulation of dynamin 2 and G protein-coupled receptor kinase 2 in rat nucleus accumbens during acute and repeated cocaine administration.

29 Sep 2009 Exposure to cocaine causes many neuroadaptations including alterations in several neurotransmitter receptors and transporters. This study investigated potential mechanisms of cocaine-induced receptor and transporter regulation by measuring levels of ... Read more...

Intrarenal dopamine attenuates deoxycorticosterone acetate/high salt-induced blood pressure elevation in part through activation of a medullary cyclooxygenase 2 pathway.

19 Sep 2009 Locally produced dopamine in the renal proximal tubule inhibits salt and fluid reabsorption, and a dysfunctional intrarenal dopaminergic system has been reported in essential hypertension and experimental hypertension models. Using ... Read more...

Latest indexed articles for 'Benzazepines - Pharmacology'

These are the very latest articles for this heading:

• Indolobenzazepin-7-ones and 6-, 8-, and 9-membered ring derivatives as tubulin polymerization inhibitors: synthesis and structure--activity relationship studies. 6 Oct 2009
• Regulation of dynamin 2 and G protein-coupled receptor kinase 2 in rat nucleus accumbens during acute and repeated cocaine administration. 29 Sep 2009
• Intrarenal dopamine attenuates deoxycorticosterone acetate/high salt-induced blood pressure elevation in part through activation of a medullary cyclooxygenase 2 pathway. 19 Sep 2009
• Acute neurobehavioral effects of toluene: involvement of dopamine and NMDA receptors. 14 Sep 2009
• Dopamine controls persistence of long-term memory storage. 19 Aug 2009
• Magnetic resonance imaging left ventricular mass reduction with fixed-dose angiotensin-converting enzyme inhibitor-based regimens in patients with high-risk hypertension. 15 Aug 2009
• Dopaminergic modulation of olfactory bulb processing affects odor discrimination learning in rats. 30 Jul 2009
• Tolvaptan. 30 Jul 2009
• 'Funny' current: if heart rate slowing is not the best answer, what might be? 15 Jul 2009
• Determinants for the efficiency of anticancer drugs targeting either Aurora-A or Aurora-B kinases in human colon carcinoma cells. 5 Jul 2009
• Control of heart rate by cAMP sensitivity of HCN channels. 29 Jun 2009
• Arrestin3 mediates D(2) dopamine receptor internalization. 29 Jun 2009
• Methamphetamine induces dopamine D1 receptor-dependent endoplasmic reticulum stress-related molecular events in the rat striatum. 28 Jun 2009
• Impact of serotonin 2C receptor null mutation on physiology and behavior associated with nigrostriatal dopamine pathway function. 22 Jun 2009
• Serotonergic and dopaminergic modulation of gambling behavior as assessed using a novel rat gambling task. 15 Jun 2009
• Effects of dopamine D1 and D2 receptor antagonists on laryngeal neurophysiology in the rat. 15 Jun 2009
• Activation of phosphatidylinositol-linked D1-like receptor modulates FGF-2 expression in astrocytes via IP3-dependent Ca2+ signaling. 15 Jun 2009
• Lateral hypothalamus dopamine D1-like receptors and glucose-conditioned flavor preferences in rats. 14 Jun 2009
• 'Click' D(1) receptor agonists with a 5-HT(1A) receptor pharmacophore producing D(2) receptor activity. 14 Jun 2009
• Preclinical pharmacology of the alpha4beta2 nAChR partial agonist varenicline related to effects on reward, mood and cognition. 4 Jun 2009

See a longer list of these articles.

Technical information about 'Benzazepines'

Definition: Compounds with BENZENE fused to AZEPINES.

Registry Number: 0

Descriptor UI: D001552

Alternative terms: Benzazepines;

Related Mesh Headings: Azepines; Dibenzazepines;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D03.438.079;

History Note: 68