Benzimidazoles - Pharmacology
Research News and Information

Monday, November 23, 2009

Intrinsic resistance to the MEK1/2 inhibitor AZD6244 (ARRY-142886) is associated with weak ERK1/2 signalling and/or strong PI3K signalling in colorectal cancer cell lines.

13 Nov 2009 Mutations in KRAS or BRAF frequently manifest in constitutive activation of the MEK1/2-ERK1/2 signalling pathway. The MEK1/2-selective inhibitor, AZD6244 (ARRY-142886), blocks ERK1/2 activation and is currently undergoing clinical evaluation. Tumour ... Read more...

1- or 3-(3-Amino-2-hydroxy-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones: potent, selective, and orally efficacious norepinephrine reuptake inhibitors.

22 Sep 2009 Sequential structural modifications of the aryloxypropanamine template (e.g., atomoxetine, 2) led to a novel series of 1-(3-amino-2-hydroxy-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones as selective norepinephrine reuptake inhibitors (NRIs). ... Read more...

N-hydroxybenzimidazole inhibitors of the transcription factor LcrF in Yersinia: novel antivirulence agents.

22 Sep 2009 LcrF, a multiple adaptational response (MAR) transcription factor, regulates virulence in Yersinia pestis and Yersinia pseudotuberculosis. In a search for small molecule inhibitors of LcrF, an acrylic amide series of N-hydroxybenzimidazoles was ... Read more...

Latest indexed articles for 'Benzimidazoles - Pharmacology'

These are the very latest articles for this heading:

• Intrinsic resistance to the MEK1/2 inhibitor AZD6244 (ARRY-142886) is associated with weak ERK1/2 signalling and/or strong PI3K signalling in colorectal cancer cell lines. 13 Nov 2009
• 1- or 3-(3-Amino-2-hydroxy-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones: potent, selective, and orally efficacious norepinephrine reuptake inhibitors. 22 Sep 2009
• N-hydroxybenzimidazole inhibitors of the transcription factor LcrF in Yersinia: novel antivirulence agents. 22 Sep 2009
• Impaired function of coronary BK(Ca) channels in metabolic syndrome. 9 Sep 2009
• Influence of the side chain next to C-terminal benzimidazole in opioid pseudopeptides containing the Dmt-Tic pharmacophore. 8 Sep 2009
• Following the hedgehog to new cancer therapies. 31 Aug 2009
• Inhibition of MEK signaling enhances the ability of cytarabine to induce growth arrest and apoptosis of acute myelogenous leukemia cells. 30 Aug 2009
• Dual inhibition of mitogen-activated protein kinase kinase and mammalian target of rapamycin in differentiated and anaplastic thyroid cancer. 30 Aug 2009
• The protective role of telmisartan against nephrotoxicity induced by X-ray contrast media in rat model. 30 Aug 2009
• Effect of carbendazim resistance on trichothecene production and aggressiveness of Fusarium graminearum. 30 Aug 2009
• Blockade of MEK signaling potentiates 5-Aza-2'-deoxycytidine-induced apoptosis and upregulation of p21(waf1) in acute myelogenous leukemia cells. 30 Aug 2009
• Exaggerated blood pressure variability superimposed on hypertension aggravates cardiac remodeling in rats via angiotensin II system-mediated chronic inflammation. 22 Aug 2009
• Cerebroprotective action of telmisartan by inhibition of macrophages/microglia expressing HMGB1 via a peroxisome proliferator-activated receptor gamma-dependent mechanism. 19 Aug 2009
• BMS-536924 sensitizes human epithelial ovarian cancer cells to the PARP inhibitor, 3-aminobenzamide. 19 Aug 2009
• Chronic treatment with losartan results in sufficient serum levels of the metabolite EXP3179 for PPARgamma activation. 15 Aug 2009
• The neurokinin-1 receptor modulates the methamphetamine-induced striatal apoptosis and nitric oxide formation in mice. 11 Aug 2009
• Activation of the BK(Ca) channel increases outflow facility and decreases trabecular meshwork cell volume. 30 Jul 2009
• Candesartan: widening indications for this angiotensin II receptor blocker? 30 Jul 2009
• Emedastine difumarate: a review of its potential ameliorating effect for tissue remodeling in allergic diseases. 30 Jul 2009
• Leptin modulates ACAT1 expression and cholesterol efflux from human macrophages. 30 Jul 2009

See a longer list of these articles.

Technical information about 'Benzimidazoles'

Definition: Compounds with a BENZENE fused to IMIDAZOLES.

Registry Number: 0

Descriptor UI: D001562

Alternative terms: Benzimidazoles;

Related Mesh Headings: Imidazoles;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D03.438.103;