Benzimidazoles
Research News and Information

Sunday, November 22, 2009

Synthesis and evaluation of a novel class of G-quadruplex-stabilizing small molecules based on the 1,3-phenylene-bis(piperazinyl benzimidazole) system.

15 Nov 2009 Achieving stabilization of telomeric DNA in G-quadruplex conformation by various organic compounds has been an important goal for the medicinal chemists seeking to develop new anticancer agents. Several compounds are known to stabilize ... Read more...

Intrinsic resistance to the MEK1/2 inhibitor AZD6244 (ARRY-142886) is associated with weak ERK1/2 signalling and/or strong PI3K signalling in colorectal cancer cell lines.

13 Nov 2009 Mutations in KRAS or BRAF frequently manifest in constitutive activation of the MEK1/2-ERK1/2 signalling pathway. The MEK1/2-selective inhibitor, AZD6244 (ARRY-142886), blocks ERK1/2 activation and is currently undergoing clinical evaluation. Tumour ... Read more...

1- or 3-(3-Amino-2-hydroxy-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones: potent, selective, and orally efficacious norepinephrine reuptake inhibitors.

22 Sep 2009 Sequential structural modifications of the aryloxypropanamine template (e.g., atomoxetine, 2) led to a novel series of 1-(3-amino-2-hydroxy-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones as selective norepinephrine reuptake inhibitors (NRIs). ... Read more...

Latest indexed articles for 'Benzimidazoles'

These are the very latest articles for this heading:

• Synthesis and evaluation of a novel class of G-quadruplex-stabilizing small molecules based on the 1,3-phenylene-bis(piperazinyl benzimidazole) system. 15 Nov 2009
• Intrinsic resistance to the MEK1/2 inhibitor AZD6244 (ARRY-142886) is associated with weak ERK1/2 signalling and/or strong PI3K signalling in colorectal cancer cell lines. 13 Nov 2009
• 1- or 3-(3-Amino-2-hydroxy-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones: potent, selective, and orally efficacious norepinephrine reuptake inhibitors. 22 Sep 2009
• N-hydroxybenzimidazole inhibitors of the transcription factor LcrF in Yersinia: novel antivirulence agents. 22 Sep 2009
• Effects of telmisartan, ramipril, and their combination on left ventricular hypertrophy in individuals at high vascular risk in the Ongoing Telmisartan Alone and in Combination With Ramipril Global End Point Trial and the Telmisartan Randomized Assessment Study in ACE Intolerant Subjects With Cardiovascular Disease. 19 Sep 2009
• Blood pressure control determines improvement in diastolic dysfunction in early hypertension. 15 Sep 2009
• [Stroke prevention in atrial fibrillation. Marcumar alternative in sight] 15 Sep 2009
• Impaired function of coronary BK(Ca) channels in metabolic syndrome. 9 Sep 2009
• Influence of the side chain next to C-terminal benzimidazole in opioid pseudopeptides containing the Dmt-Tic pharmacophore. 8 Sep 2009
• Medicine. Disrupting Hedgehog may reverse advanced cancer, if only temporarily. 2 Sep 2009
• [Anticoagulation in atrial fibrillation. Stroke can be prevented this way] Sep 2009
• Following the hedgehog to new cancer therapies. 31 Aug 2009
• Inhibition of the hedgehog pathway in advanced basal-cell carcinoma. 31 Aug 2009
• Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449. 31 Aug 2009
• Lessons learned from the ONTARGET and TRANSCEND trials. 30 Aug 2009
• A logical approach to surgical thromboprophylaxis. 30 Aug 2009
• Additive antihypertensive and antihypertrophic effects of long-acting Ca blockers in uncontrolled hypertensive patients with angiotensin-receptor blocker based treatment. 30 Aug 2009
• Inhibition of MEK signaling enhances the ability of cytarabine to induce growth arrest and apoptosis of acute myelogenous leukemia cells. 30 Aug 2009
• Dual inhibition of mitogen-activated protein kinase kinase and mammalian target of rapamycin in differentiated and anaplastic thyroid cancer. 30 Aug 2009
• Telmisartan in migraine prophylaxis: a randomized, placebo-controlled trial. 30 Aug 2009

See a longer list of these articles.

Technical information about 'Benzimidazoles'

Definition: Compounds with a BENZENE fused to IMIDAZOLES.

Registry Number: 0

Descriptor UI: D001562

Alternative terms: Benzimidazoles;

Related Mesh Headings: Imidazoles;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D03.438.103;