Benzodiazepines - Pharmacology
Research News and Information

Sunday, November 22, 2009

The association of olanzapine-induced weight gain with peroxisome proliferator-activated receptor-gamma2 Pro12Ala polymorphism in patients with schizophrenia.

29 Sep 2009 Olanzapine is a second-generation antipsychotic that may cause weight gain and metabolic syndrome in some cases. The peroxisome proliferator-activated receptor (PPAR)-gamma is an important gene in the progress of type II diabetes and metabolic ... Read more...

The impact of diazepam's discovery on the treatment and understanding of status epilepticus.

6 Aug 2009 The fortuitous discovery of the benzodiazepines and the subsequent application of these agents to the treatment of status epilepticus (SE) heralds in the modern age of treating this neurologic emergency. More than 50 years after their discovery, the ... Read more...

Longer-term treatment of patients with bipolar disorder: a 9-month observational study in Central and Eastern Europe, the Middle East and Africa.

30 Jul 2009 OBJECTIVE: To compare the longer-term outcomes of pharmacological treatment of patients with a diagnosis of bipolar affective disorder currently suffering a manic or hypomanic episode prescribed olanzapine or non-olanzapine medication in ... Read more...

Latest indexed articles for 'Benzodiazepines - Pharmacology'

These are the very latest articles for this heading:

• The association of olanzapine-induced weight gain with peroxisome proliferator-activated receptor-gamma2 Pro12Ala polymorphism in patients with schizophrenia. 29 Sep 2009
• The impact of diazepam's discovery on the treatment and understanding of status epilepticus. 6 Aug 2009
• Longer-term treatment of patients with bipolar disorder: a 9-month observational study in Central and Eastern Europe, the Middle East and Africa. 30 Jul 2009
• Antagonism of the ethanol-like discriminative stimulus effects of ethanol, pentobarbital, and midazolam in cynomolgus monkeys reveals involvement of specific GABA(A) receptor subtypes. 27 Jul 2009
• Structure-based design of a benzodiazepine scaffold yields a potent allosteric inhibitor of hepatitis C NS5B RNA polymerase. 21 Jul 2009
• Structure-based discovery of low molecular weight compounds that stimulate neurite outgrowth and substitute for nerve growth factor. 15 Jul 2009
• GABAergic analgesia: new insights from mutant mice and subtype-selective agonists. 14 Jul 2009
• The search for potent, small molecule NNRTIs: A review. Jul 2009
• The complexity of the GABAA receptor shapes unique pharmacological profiles. 30 Jun 2009
• Pharmacology of commonly used analgesics and sedatives in the ICU: benzodiazepines, propofol, and opioids. 29 Jun 2009
• Antipsychotic treatment alters protein expression associated with presynaptic function and nervous system development in rat frontal cortex. 29 Jun 2009
• Validating novel targets for pharmacological interventions in schizophrenia. 29 Jun 2009
• The effect of olanzapine pretreatment on acute cocaine toxicity in mice. 29 Jun 2009
• Bacterial ortholog of mammalian translocator protein (TSPO) with virulence regulating activity. 28 Jun 2009
• Regulation of glutamate transport in developing rat oligodendrocytes. 15 Jun 2009
• A randomized controlled trial of the effect of sublingual orally disintegrating olanzapine versus oral olanzapine on body mass index: the PLATYPUS Study. 14 Jun 2009
• Cost-effectiveness of quetiapine plus mood stabilizers compared with mood stabilizers alone in the maintenance therapy of bipolar I disorder: results of a Markov model analysis. 30 May 2009
• Targeting cognition in schizophrenia research: from etiology to treatment. 30 May 2009
• Bz-423 superoxide signals B cell apoptosis via Mcl-1, Bak, and Bax. 25 May 2009
• Compensatory enhancement of intrinsic spiking upon NKCC1 disruption in neonatal hippocampus. 25 May 2009

See a longer list of these articles.

Technical information about 'Benzodiazepines'

Definition: A group of two-ring heterocyclic compounds consisting of a benzene ring fused to a diazepine ring.

Registry Number: 12794-10-4

Descriptor UI: D001569

Alternative terms: Benzodiazepines; Benzodiazepine Compounds; Benzodiazepine;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D03.438.079.080;

History Note: 75

Technical Notes: do not confuse with BENZODIAZEPINONES