Biflavonoids - Pharmacology
Research News and Information

Sunday, November 22, 2009

Inhibition of P-glycoprotein function by procyanidine on blood-brain barrier.

29 Jun 2009 The inhibitory effects of procyanidine, one of the components from the bark of Pinus massoniana Lamb, on the P-glycoprotein (P-gp) function of the blood-brain barrier (BBB) were studied using in vitro rat brain microvessel endothelial cells (RBMECs) ... Read more...

Role of oxidation-triggered activation of JNK and p38 MAPK in black tea polyphenols induced apoptotic death of A375 cells.

20 Jun 2009 Theaflavins (TF) and thearubigins (TR) are the major polyphenols of black tea. Our previous study revealed that TF- and TR-induced apoptosis of human malignant melanoma cells (A375) is executed via a mitochondria-mediated pathway. In our present ... Read more...

Effects of theaflavins on melanin biosynthesis in mouse b16 melanoma cells.

5 Jun 2009 In this study, we examined the effects of theaflavins, polyphenols in black tea, on alpha melanocyte-stimulating hormone (alphaMSH)-induced melanogenesis in mouse B16 melanoma cells. Among theaflavins, theaflavin-3,3'-digallate (TF-3) exhibited a ... Read more...

Latest indexed articles for 'Biflavonoids - Pharmacology'

These are the very latest articles for this heading:

• Inhibition of P-glycoprotein function by procyanidine on blood-brain barrier. 29 Jun 2009
• Role of oxidation-triggered activation of JNK and p38 MAPK in black tea polyphenols induced apoptotic death of A375 cells. 20 Jun 2009
• Effects of theaflavins on melanin biosynthesis in mouse b16 melanoma cells. 5 Jun 2009
• Antifungal activity of black tea polyphenols (catechins and theaflavins) against Candida species. 3 May 2009
• Cinchonain Ib isolated from Eriobotrya japonica induces insulin secretion in vitro and in vivo. May 2009
• Biflavonoids from Araucaria angustifolia protect against DNA UV-induced damage. 4 Apr 2009
• Cocoa procyanidins attenuate 4-hydroxynonenal-induced apoptosis of PC12 cells by directly inhibiting mitogen-activated protein kinase kinase 4 activity. 23 Feb 2009
• Choice of DMEM, formulated with or without pyruvate, plays an important role in assessing the in vitro cytotoxicity of oxidants and prooxidant nutraceuticals. 28 Jan 2009
• Morelloflavone, a biflavonoid, inhibits tumor angiogenesis by targeting rho GTPases and extracellular signal-regulated kinase signaling pathways. 13 Jan 2009
• [Protective effect of hawthorn leaf procyanidins on cardiomyocytes of neonatal rats subjected to simulated ischemia-reperfusion injury] 30 Dec 2008
• Bioactive compounds of inhibiting xanthine oxidase from Selaginella labordei. 30 Dec 2008
• Antihypertensive effect of French maritime pine bark extract (Flavangenol): possible involvement of endothelial nitric oxide-dependent vasorelaxation. 30 Dec 2008
• Theaflavins from black tea, especially theaflavin-3-gallate, reduce the incorporation of cholesterol into mixed micelles. 22 Dec 2008
• Chemical constituents of the plants of the genus Calophyllum. 29 Nov 2008
• Biflavonoids from Daphne feddei and their inhibitory activities against nitric oxide production. 29 Nov 2008
• Short-circuiting RNA splicing. 29 Nov 2008
• Procyanidin effects on oesophageal adenocarcinoma cells strongly depend on flavan-3-ol degree of polymerization. 29 Nov 2008
• PCR differential display-based identification of regulator of G protein signaling 10 as the target gene in human colon cancer cells induced by black tea polyphenol theaflavin monogallate. 29 Oct 2008
• Procyanidin induces apoptosis and necrosis of prostate cancer cell line PC-3 in a mitochondrion-dependent manner. 28 Oct 2008
• Morelloflavone blocks injury-induced neointimal formation by inhibiting vascular smooth muscle cell migration. 28 Sep 2008

See a longer list of these articles.

Technical information about 'Biflavonoids'

Definition: Dimers (homo and hetero) of FLAVONOIDS.

Registry Number: 0

Descriptor UI: D044946

Alternative terms: Biflavonoids;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D03.438.150.266.450.190; D03.830.219.266.450.190;

History Note: 2004