Binding Sites - Research News and Information

Thursday, January 08, 2009

Transcriptional profiling defines the effects of nickel in human epidermal keratinocytes.

29 Nov 2008 Nickel is a ubiquitous and virtually unavoidable environmental pollutant and occupational hazard, but its molecular and cellular effects are not well understood. Human epidermal keratinocytes are the sentinel and the primary target for nickel. We ... Read more...

The angiopoietin-2 gene of endothelial cells is up-regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA-2 and Ets-1.

29 Nov 2008 Angiopoietins are ligands of the endothelial cell tyrosine kinase receptor Tie2. Angiopoietin-1 (Ang-1) is widely expressed in human normal adult tissues and promotes blood vessel maturation and stabilization by inducing Tie2 receptor ... Read more...

Crystal structures of the starch-binding domain from Rhizopus oryzae glucoamylase reveal a polysaccharide-binding path.

13 Nov 2008 GA (glucoamylase) hydrolyses starch and polysaccharides to beta-D-glucose. RoGA (Rhizopus oryzae GA) consists of two functional domains, an N-terminal SBD (starch-binding domain) and a C-terminal catalytic domain, which are connected by an ... Read more...

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Latest indexed articles for 'Binding Sites'

These are the very latest articles for this heading:

• Transcriptional profiling defines the effects of nickel in human epidermal keratinocytes. 29 Nov 2008
• The angiopoietin-2 gene of endothelial cells is up-regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA-2 and Ets-1. 29 Nov 2008
• Crystal structures of the starch-binding domain from Rhizopus oryzae glucoamylase reveal a polysaccharide-binding path. 13 Nov 2008
• Asp218 participates with Asp213 to bind a Ca2+ atom into the S1 subsite of aminopeptidase A: a key element for substrate specificity. 13 Nov 2008
• The binding of heparin to the extracellular matrix of endothelial cells up-regulates the synthesis of an antithrombotic heparan sulfate proteoglycan. 30 Oct 2008
• Internalization and degradation of heparin is not required for stimulus of heparan sulfate proteoglycan synthesis. 30 Oct 2008
• Identification of two regulatory binding sites which confer myotube specific expression of the mono-ADP-ribosyltransferase ART1 gene. 19 Oct 2008
• Surface sites for engineering allosteric control in proteins. 15 Oct 2008
• Regulatory network analyses reveal genome-wide potentiation of LIF signaling by glucocorticoids and define an innate cell defense response. 15 Oct 2008
• Conformational transition of Sec machinery inferred from bacterial SecYE structures. 14 Oct 2008
• Cloning, expression, and characterization of novel thermostable family 7 cellobiohydrolases. 13 Oct 2008
• The Bet v 1 fold: an ancient, versatile scaffold for binding of large, hydrophobic ligands. 13 Oct 2008
• The histone gene cell cycle regulator HiNF-P is a unique zinc finger transcription factor with a novel conserved auxiliary DNA-binding motif. 12 Oct 2008
• New insights into SRY regulation through identification of 5' conserved sequences. 12 Oct 2008
• The dual transcriptional regulator CysR in Corynebacterium glutamicum ATCC 13032 controls a subset of genes of the McbR regulon in response to the availability of sulphide acceptor molecules. 12 Oct 2008
• Transcriptional regulation of subclass 5b fimbriae. 12 Oct 2008
• Direct metal transfer between periplasmic proteins identifies a bacterial copper chaperone. 9 Oct 2008
• Small molecule-induced allosteric activation of the Vibrio cholerae RTX cysteine protease domain. 8 Oct 2008
• KANADI1 regulates adaxial-abaxial polarity in Arabidopsis by directly repressing the transcription of ASYMMETRIC LEAVES2. 8 Oct 2008
• The LPS-induced transcriptional upregulation of the chicken lysozyme locus involves CTCF eviction and noncoding RNA transcription. 8 Oct 2008

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Technical information about 'Binding Sites'

Definition: The parts of a macromolecule that directly participate in its specific combination with another molecule.

Descriptor UI: D001665

Alternative terms: Binding Sites; Site, Binding; Sites, Binding; Binding Site; Combining Site; Combining Sites; Site, Combining; Sites, Combining;

Related Mesh Headings: Protein Binding; Receptors, Cell Surface;

Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects;

Tree Number: G02.111.570.120;

History Note: 68

Technical Notes: usually NIM; do not use as substitute for chemistry or metabolic mechanism of binding; do not coordinate with receptors terms unless specifically discussed