Binding Sites
Research News and Information

Sunday, November 22, 2009

The second Cu(II)-binding site in a proton-rich environment interferes with the aggregation of amyloid-beta(1-40) into amyloid fibrils.

15 Nov 2009 The overall morphology and Cu(II) ion coordination for the aggregated amyloid-beta(1-40) [Abeta(1-40)] in N-ethylmorpholine (NEM) buffer are affected by Cu(II) ion concentration. This effect is investigated by transmission electron microscopy (TEM), ... Read more...

Interdomain contacts in flavocytochrome b(2), a mutational analysis.

15 Nov 2009 Each flavocytochrome b(2) (l-lactate cytochrome c oxidoreductase) subunit consists of an N-terminal cytochrome domain and a C-terminal flavodehydrogenase (FDH) domain. In the enzyme crystal structure, only two heme domains are visible per enzyme ... Read more...

Identification and characterization of binding sites on S100A7, a participant in cancer and inflammation pathways.

8 Nov 2009 S100A7 (psoriasin) is a member of the S100 family of signaling proteins. It is implicated in and considered a therapeutic target for inflammation and cancer, yet no small molecule ligands for S100A7 have been identified. To begin the development of ... Read more...

Latest indexed articles for 'Binding Sites'

These are the very latest articles for this heading:

• The second Cu(II)-binding site in a proton-rich environment interferes with the aggregation of amyloid-beta(1-40) into amyloid fibrils. 15 Nov 2009
• Interdomain contacts in flavocytochrome b(2), a mutational analysis. 15 Nov 2009
• Identification and characterization of binding sites on S100A7, a participant in cancer and inflammation pathways. 8 Nov 2009
• The identity of the nucleophile substitution may influence metal interactions with the cleavage site of the minimal hammerhead ribozyme. 8 Nov 2009
• Solution structure and functional characterization of human plasminogen kringle 5. Nov 2009
• How do transcription factors select specific binding sites in the genome? 30 Oct 2009
• C-terminal region-dependent change of antibody-binding to the Eighth Reelin repeat reflects the signaling activity of Reelin. 30 Oct 2009
• Structural basis of typhoid: Salmonella typhi type IVb pilin (PilS) and cystic fibrosis transmembrane conductance regulator interaction. 30 Oct 2009
• Combining interface core and whole interface descriptors in postscan processing of protein-protein docking models. 30 Oct 2009
• Engineering monomeric streptavidin and its ligands with infinite affinity in binding but reversibility in interaction. 30 Oct 2009
• Substrate binding modifies the hinge bending characteristics of human 3-phosphoglycerate kinase: a molecular dynamics study. 30 Oct 2009
• Prion protein region 23-32 interacts with tubulin and inhibits microtubule assembly. 30 Oct 2009
• KIR2DS4 is a product of gene conversion with KIR3DL2 that introduced specificity for HLA-A*11 while diminishing avidity for HLA-C. 24 Oct 2009
• Active-site determinants of substrate recognition by the metalloproteinases TACE and ADAM10. 21 Oct 2009
• A general and efficient approach for NMR studies of peptide dynamics in class I MHC peptide binding grooves. 18 Oct 2009
• Structure and inhibition of human diamine oxidase. 18 Oct 2009
• Biochemical characterization of the multidrug regulator QacR distinguishes residues that are crucial to multidrug binding and induction of qacA transcription. 18 Oct 2009
• Copper binding to beta-2-microglobulin and its pre-amyloid oligomers. 18 Oct 2009
• Thermodynamic characterization of the interaction between the C-terminal domain of extracellular superoxide dismutase and heparin by isothermal titration calorimetry. 18 Oct 2009
• Matrix metalloproteinase 2 inhibition: combined quantum mechanics and molecular mechanics studies of the inhibition mechanism of (4-phenoxyphenylsulfonyl)methylthiirane and its oxirane analogue. 18 Oct 2009

See a longer list of these articles.

Technical information about 'Binding Sites'

Definition: The parts of a macromolecule that directly participate in its specific combination with another molecule.

Descriptor UI: D001665

Alternative terms: Binding Sites; Site, Binding; Sites, Binding; Binding Site; Combining Site; Combining Sites; Site, Combining; Sites, Combining;

Related Mesh Headings: Protein Binding; Receptors, Cell Surface;

Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects;

Tree Number: G02.111.570.120;

History Note: 68

Technical Notes: usually NIM; do not use as substitute for chemistry or metabolic mechanism of binding; do not coordinate with receptors terms unless specifically discussed