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Binding Sites
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Definition of 'Binding Sites'

The parts of a macromolecule that directly participate in its specific combination with another molecule.

Common names: Binding Sites; Site, Binding; Sites, Binding; Binding Site; Combining Site; Combining Sites; Site, Combining; Sites, Combining

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Sunday, November 22, 2009

The second Cu(II)-binding site in a proton-rich environment interferes with the aggregation of amyloid-beta(1-40) into amyloid fibrils.

15 Nov 2009 The overall morphology and Cu(II) ion coordination for the aggregated amyloid-beta(1-40) [Abeta(1-40)] in N-ethylmorpholine (NEM) buffer are affected by Cu(II) ion concentration. This effect is investigated by transmission electron microscopy (TEM), ... Read more...


Interdomain contacts in flavocytochrome b(2), a mutational analysis.

15 Nov 2009 Each flavocytochrome b(2) (l-lactate cytochrome c oxidoreductase) subunit consists of an N-terminal cytochrome domain and a C-terminal flavodehydrogenase (FDH) domain. In the enzyme crystal structure, only two heme domains are visible per enzyme ... Read more...


Identification and characterization of binding sites on S100A7, a participant in cancer and inflammation pathways.

8 Nov 2009 S100A7 (psoriasin) is a member of the S100 family of signaling proteins. It is implicated in and considered a therapeutic target for inflammation and cancer, yet no small molecule ligands for S100A7 have been identified. To begin the development of ... Read more...

 

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Technical information about 'Binding Sites'

Definition: The parts of a macromolecule that directly participate in its specific combination with another molecule.

Descriptor UI: D001665

Alternative terms: Binding Sites; Site, Binding; Sites, Binding; Binding Site; Combining Site; Combining Sites; Site, Combining; Sites, Combining;

Related Mesh Headings: Protein Binding; Receptors, Cell Surface;

Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects;

Tree Number: G02.111.570.120;

History Note: 68

Technical Notes: usually NIM; do not use as substitute for chemistry or metabolic mechanism of binding; do not coordinate with receptors terms unless specifically discussed

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