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Biological Markers - Analysis
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Definition of 'Biological Markers'

Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.

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Sunday, November 22, 2009

Radiation response of cancer stem-like cells from established human cell lines after sorting for surface markers.

13 Nov 2009 PURPOSE: A subpopulation of cancer stem-like cells (CSLC) is hypothesized to exist in different cancer cell lines and to mediate radioresistance in solid tumors. METHODS AND MATERIALS: Cells were stained for CSLC markers and sorted ... Read more...


How a US regulator can encourage new science.

30 Oct 2009 The Center for Drug Evaluation and Research at the US Food and Drug Administration (FDA) is developing a process to qualify biomarkers for use under particular conditions. As part of this effort, Goodsaid et al. have carried out work, described in ... Read more...


Diclofenac sodium inhibits NFkappaB transcription in osteoclasts.

30 Oct 2009 A non-steroidal anti-inflammatory drug, diclofenac, acts efficiently against inflammation; however, down-regulation of diclofenac on bone remodeling has raised concerns. The inhibitory mechanisms of diclofenac are poorly understood. We hypothesized ... Read more...

 

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Technical information about 'Biological Markers'

Definition: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.

Registry Number: 0

Descriptor UI: D015415

Alternative terms: Biological Markers; Markers, Biological; Biomarkers; Marker, Biological; Biological Marker; Biologic Marker; Marker, Biologic; Biologic Markers; Markers, Biologic; Viral Markers; Viral Marker; Marker, Viral; Markers, Viral; Biochemical Marker; Marker, Biochemical; Markers, Biochemical; Biochemical Markers; Surrogate Endpoints; Endpoints, Surrogate; Surrogate End Points; End Points, Surrogate; Surrogate Endpoint; Endpoint, Surrogate; Surrogate End Point; End Point, Surrogate; Markers, Immunologic; Marker, Immunologic; Immunologic Marker; Immunologic Markers; Immune Marker; Marker, Immune; Immune Markers; Markers, Immune; Markers, Laboratory; Laboratory Markers; Marker, Laboratory; Laboratory Marker; Serum Markers; Markers, Serum; Serum Marker; Marker, Serum; Surrogate Markers; Markers, Surrogate; Surrogate Marker; Marker, Surrogate; Markers, Clinical; Clinical Markers; Marker, Clinical; Clinical Marker;

Related Mesh Headings: Molecular Probes;

Allowable Qualifiers: analysis; blood; cerebrospinal fluid; chemistry; metabolism; urine;

Tree Number: D23.101;

History Note: 89

Technical Notes: IM general only; coordinate NIM with specific substance (IM); note that many specific markers are available; DF: BIOL MARKERS

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