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Biological Markers - Research News and Information

Thursday, January 08, 2009

Definition of 'Biological Markers'

Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.

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Molecular identification and functional characterization of the vitamin C transporters expressed by Sertoli cells.

29 Nov 2008 Vitamin C is an essential micronutrient for the development of male germ cells. In the gonad, the germ cells are isolated from the systemic circulation by the blood-testis barrier, which consists of a basal layer of Sertoli cells that communicate ... Read more...


PERK is essential for neonatal skeletal development to regulate osteoblast proliferation and differentiation.

29 Nov 2008 Loss of function mutations of Perk (eukaryotic translation initiation factor 2 alpha kinase 3) in humans and mice cause severe neonatal developmental defects, including diabetes, growth retardation and multiple skeletal dysplasias. Comprehensive ... Read more...


Measures of cutaneous human papillomavirus infection in normal tissues as biomarkers of HPV in corresponding nonmelanoma skin cancers.

13 Nov 2008 Cutaneous human papillomavirus (HPV) may be associated with the development of nonmelanoma skin cancer (NMSC), as suggested by reports of HPV DNA in NMSC tumors. HPV has also been investigated as an NMSC risk factor in epidemiologic studies, ... Read more...

 

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Technical information about 'Biological Markers'

Definition: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.

Registry Number: 0

Descriptor UI: D015415

Alternative terms: Biological Markers; Markers, Biological; Biomarkers; Marker, Biological; Biological Marker; Biologic Marker; Marker, Biologic; Biologic Markers; Markers, Biologic; Viral Markers; Viral Marker; Marker, Viral; Markers, Viral; Biochemical Marker; Marker, Biochemical; Markers, Biochemical; Biochemical Markers; Surrogate Endpoints; Endpoints, Surrogate; Surrogate End Points; End Points, Surrogate; Surrogate Endpoint; Endpoint, Surrogate; Surrogate End Point; End Point, Surrogate; Markers, Immunologic; Marker, Immunologic; Immunologic Marker; Immunologic Markers; Immune Marker; Marker, Immune; Immune Markers; Markers, Immune; Markers, Laboratory; Laboratory Markers; Marker, Laboratory; Laboratory Marker; Serum Markers; Markers, Serum; Serum Marker; Marker, Serum; Surrogate Markers; Markers, Surrogate; Surrogate Marker; Marker, Surrogate; Markers, Clinical; Clinical Markers; Marker, Clinical; Clinical Marker;

Related Mesh Headings: Molecular Probes;

Allowable Qualifiers: analysis; blood; cerebrospinal fluid; chemistry; metabolism; urine;

Tree Number: D23.101;

History Note: 89

Technical Notes: IM general only; coordinate NIM with specific substance (IM); note that many specific markers are available; DF: BIOL MARKERS

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