Bone Morphogenetic Proteins - Biosynthesis
Research News and Information

Monday, November 23, 2009

Tbx1 regulates the BMP-Smad1 pathway in a transcription independent manner.

23 Jun 2009 Tbx1 is a T-box transcription factor implicated in DiGeorge syndrome. The molecular function of Tbx1 is unclear although it can transactivate reporters with T-box binding elements. We discovered that Tbx1 binds Smad1 and suppresses the Bmp4/Smad1 ... Read more...

Sclerostin in mineralized matrices and van Buchem disease.

30 May 2009 Sclerostin is an inhibitor of bone formation expressed by osteocytes. We hypothesized that sclerostin is expressed by cells of the same origin and also embedded within mineralized matrices. In this study, we analyzed (a) sclerostin expression using ... Read more...

Bone morphogenetic protein-10 suppresses the growth and aggressiveness of prostate cancer cells through a Smad independent pathway.

15 Apr 2009 PURPOSE: BMPs have been implicated in the development of bone metastasis in prostate cancer. We investigated the role of BMP-10 in prostate cancer and prostate cancer cells. MATERIALS AND METHODS: BMP-10 expression was examined in human prostate ... Read more...

Latest indexed articles for 'Bone Morphogenetic Proteins - Biosynthesis'

These are the very latest articles for this heading:

• Tbx1 regulates the BMP-Smad1 pathway in a transcription independent manner. 23 Jun 2009
• Sclerostin in mineralized matrices and van Buchem disease. 30 May 2009
• [Ultrastructure and biological function of osteocytes] 29 Apr 2009
• Bone morphogenetic protein-10 suppresses the growth and aggressiveness of prostate cancer cells through a Smad independent pathway. 15 Apr 2009
• Molecular and toxicologic research in newborn hypospadiac male rats following in utero exposure to di-n-butyl phthalate (DBP). 3 Apr 2009
• Endogenous bone morphogenetic proteins in human bone marrow-derived multipotent mesenchymal stromal cells. 18 Mar 2009
• Osteoinductive capacity and heat stability of recombinant human bone morphogenetic protein-2 produced by Escherichia coli and dimerized by biochemical processing. 19 Feb 2009
• The prognostic significance of BMP-6 signaling in prostate cancer. 15 Oct 2008
• Promoter methylation of the bone morphogenetic protein-6 gene in association with adult T-cell leukemia. 13 Oct 2008
• Expression, purification and osteogenic bioactivity of recombinant human BMP-4, -9, -10, -11 and -14. 2 Oct 2008
• Metformin enhances the differentiation and mineralization of osteoblastic MC3T3-E1 cells via AMP kinase activation as well as eNOS and BMP-2 expression. 18 Aug 2008
• The BMP antagonists follistatin and gremlin in normal and early osteoarthritic cartilage: an immunohistochemical study. 6 Aug 2008
• Crossveinless-2 controls bone morphogenetic protein signaling during early cardiomyocyte differentiation in P19 cells. 26 Jul 2008
• Smad7 Inhibits chondrocyte differentiation at multiple steps during endochondral bone formation and down-regulates p38 MAPK pathways. 19 Jul 2008
• The effects of lentiviral gene therapy with bone morphogenetic protein-2-producing bone marrow cells on spinal fusion in rats. 29 Jun 2008
• Stimulation of cytokines in osteoblasts cultured on enamel matrix derivative. 29 Jun 2008
• Expression and function of BMP3 during chick limb development. 30 May 2008
• NUCEL (Cell and Molecular Therapy Center): a multidisciplinary center for translational research in Brazil. 30 May 2008
• Mycoplasma infection transforms normal lung cells and induces bone morphogenetic protein 2 expression by post-transcriptional mechanisms. 13 May 2008
• Expression of alternatively spliced transcripts for a myostatin-like protein in the blackback land crab, Gecarcinus lateralis. 7 May 2008

See a longer list of these articles.

Technical information about 'Bone Morphogenetic Proteins'

Definition: Bone-growth regulatory factors that are members of the transforming growth factor-beta superfamily of proteins. They are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.

Registry Number: 0

Descriptor UI: D019485

Alternative terms: Bone Morphogenetic Proteins; Morphogenetic Proteins, Bone; Bone Morphogenetic Protein; Morphogenetic Protein, Bone;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.644.276.954.200; D12.776.467.942.200; D23.529.942.200;

Online Note: use BONE MORPHOGENETIC PROTEINS (NM) to search BONE MORPHOGENETIC PROTEIN 1981-96

History Note: 97; was BONE MORPHOGENETIC PROTEIN (NM) 1981-96

Technical Notes: general; prefer specifics