Bone Morphogenetic Proteins - Genetics
Research News and Information

Sunday, November 22, 2009

Receptor oligomerization and beyond: a case study in bone morphogenetic proteins.

5 Sep 2009 BACKGROUND: Transforming growth factor (TGF)beta superfamily members transduce signals by oligomerizing two classes of serine/threonine kinase receptors, termed type I and type II. In contrast to the large number of ligands only seven type I and ... Read more...

Pro-inflammatory cytokines TNF-related weak inducer of apoptosis (TWEAK) and TNFalpha induce the mitogen-activated protein kinase (MAPK)-dependent expression of sclerostin in human osteoblasts.

30 Jul 2009 We have recently shown that TNF-related weak inducer of apoptosis (TWEAK) is a mediator of inflammatory bone remodeling. The aim of this study was to investigate the role of TWEAK in modulating human osteoblast activity, and how TWEAK and TNFalpha ... Read more...

Extensive sequence turnover of the signal peptides of members of the GDF/BMP family: exploring their evolutionary landscape.

14 Jul 2009 We show that the predicted signal peptide (SP) sequences of the secreted factors GDF9, BMP15 and AMH are well conserved in mammals but dramatic divergence is noticed for more distant orthologs. Interestingly, bioinformatic predictions show that the ... Read more...

Latest indexed articles for 'Bone Morphogenetic Proteins - Genetics'

These are the very latest articles for this heading:

• Receptor oligomerization and beyond: a case study in bone morphogenetic proteins. 5 Sep 2009
• Pro-inflammatory cytokines TNF-related weak inducer of apoptosis (TWEAK) and TNFalpha induce the mitogen-activated protein kinase (MAPK)-dependent expression of sclerostin in human osteoblasts. 30 Jul 2009
• Extensive sequence turnover of the signal peptides of members of the GDF/BMP family: exploring their evolutionary landscape. 14 Jul 2009
• The Integrator subunits function in hematopoiesis by modulating Smad/BMP signaling. 13 Jul 2009
• Sustained BMP signaling in osteoblasts stimulates bone formation by promoting angiogenesis and osteoblast differentiation. 29 Jun 2009
• Characterization of wise protein and its molecular mechanism to interact with both Wnt and BMP signals. 22 Jun 2009
• Prostaglandin E2, Wnt, and BMP in gastric tumor mouse models. 21 Jun 2009
• The bone morphogenetic protein signaling pathway is upregulated in a mouse model of total parenteral nutrition. 2 Jun 2009
• Cell responses to bone morphogenetic proteins and peptides derived from them: biomedical applications and limitations. 31 May 2009
• Expression of bone morphogenetic proteins in giant cell tumor of bone. 30 May 2009
• Finding partners: how BMPs select their targets. 30 May 2009
• Overexpression of the transcription factor Msx1 is insufficient to drive complete regeneration of refractory stage Xenopus laevis hindlimbs. 30 May 2009
• BMP-7 as antagonist of organ fibrosis. 30 May 2009
• Cross-talk between the mitogen activated protein kinase and bone morphogenetic protein/hemojuvelin pathways is required for the induction of hepcidin by holotransferrin in primary mouse hepatocytes. 17 May 2009
• Defective pulmonary vascular remodeling in Smad8 mutant mice. 3 May 2009
• A comprehensive analysis of the dual roles of BMPs in regulating adipogenic and osteogenic differentiation of mesenchymal progenitor cells. 29 Apr 2009
• Effects of core binding factor alpha1 or bone morphogenic protein-2 overexpression on osteoblast/cementoblast-related gene expressions in NIH3T3 mouse cells and dental follicle cells. 22 Apr 2009
• BMP and BMP receptor expression during murine organogenesis. 20 Apr 2009
• Formin1 disruption confers oligodactylism and alters Bmp signaling. 18 Apr 2009
• Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis. 17 Apr 2009

See a longer list of these articles.

Technical information about 'Bone Morphogenetic Proteins'

Definition: Bone-growth regulatory factors that are members of the transforming growth factor-beta superfamily of proteins. They are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.

Registry Number: 0

Descriptor UI: D019485

Alternative terms: Bone Morphogenetic Proteins; Morphogenetic Proteins, Bone; Bone Morphogenetic Protein; Morphogenetic Protein, Bone;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.644.276.954.200; D12.776.467.942.200; D23.529.942.200;

Online Note: use BONE MORPHOGENETIC PROTEINS (NM) to search BONE MORPHOGENETIC PROTEIN 1981-96

History Note: 97; was BONE MORPHOGENETIC PROTEIN (NM) 1981-96

Technical Notes: general; prefer specifics