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Bone Morphogenetic Proteins
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Definition of 'Bone Morphogenetic Proteins'

Bone-growth regulatory factors that are members of the transforming growth factor-beta superfamily of proteins. They are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.

Common names: Bone Morphogenetic Proteins; Morphogenetic Proteins, Bone; Bone Morphogenetic Protein; Morphogenetic Protein, Bone

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Sunday, November 22, 2009

Adult cerebrospinal fluid inhibits neurogenesis but facilitates gliogenesis from fetal rat neural stem cells.

30 Oct 2009 Neural stem cells (NSCs) are a promising source for cell replacement therapies for neurological diseases. Administration of NSCs into the cerebrospinal fluid (CSF) offers a nontraumatic transplantation method into the brain. However, cell survival ... Read more...


The fibrodysplasia ossificans progressiva R206H ACVR1 mutation activates BMP-independent chondrogenesis and zebrafish embryo ventralization.

10 Oct 2009 Patients with classic fibrodysplasia ossificans progressiva, a disorder characterized by extensive extraskeletal endochondral bone formation, share a recurrent mutation (R206H) within the glycine/serine-rich domain of ACVR1/ALK2, a bone ... Read more...


The spatial patterning of mouse cone opsin expression is regulated by bone morphogenetic protein signaling through downstream effector COUP-TF nuclear receptors.

5 Oct 2009 Cone photopigments, known as opsins, are pivotal elements and the first detection module used in color vision. In mice, cone photoreceptors are distributed throughout the retina, and short-wavelength (S) and medium-wavelength (M) opsins have unique ... Read more...

 

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Technical information about 'Bone Morphogenetic Proteins'

Definition: Bone-growth regulatory factors that are members of the transforming growth factor-beta superfamily of proteins. They are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.

Registry Number: 0

Descriptor UI: D019485

Alternative terms: Bone Morphogenetic Proteins; Morphogenetic Proteins, Bone; Bone Morphogenetic Protein; Morphogenetic Protein, Bone;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.644.276.954.200; D12.776.467.942.200; D23.529.942.200;

Online Note: use BONE MORPHOGENETIC PROTEINS (NM) to search BONE MORPHOGENETIC PROTEIN 1981-96

History Note: 97; was BONE MORPHOGENETIC PROTEIN (NM) 1981-96

Technical Notes: general; prefer specifics

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