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Bone Remodeling - Drug effects
Research News and Information
Definition of 'Bone Remodeling'The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS. |
Monday, November 23, 2009
27 Sep 2009 
AIMS: It has long been demonstrated that epidermal growth factor (EGF) has catabolic effects on bone. Thus, we examined the role of EGF in regulating mechanically induced bone modeling in a rat model of orthodontic tooth movement. MAIN METHODS: The ... Read more...
Inhibition of glycogen synthase kinase-3beta attenuates glucocorticoid-induced bone loss.
23 Sep 2009 AIMS: Long-term glucocorticoid administration is known to induce bone deterioration. Glycogen synthase kinase-3beta (GSK-3beta) signaling reportedly participates in bone remodeling. This study investigated whether GSK-3beta inhibitor could regulate ... Read more...
Short-term effects of parathyroid hormone on rat lumbar vertebrae.
30 Aug 2009 STUDY DESIGN: This study is an experimental study in the rat osteopenia model. OBJECTIVE: The aim of this study was to evaluate the short-term effects of daily application of parathyroid hormone (PTH) on bone quality and quantity using a new ... Read more...
Latest indexed articles for 'Bone Remodeling - Drug effects'
These are the very latest articles for this heading:
- Local delivery of EGF-liposome mediated bone modeling in orthodontic tooth movement by increasing RANKL expression. 27 Sep 2009
- Inhibition of glycogen synthase kinase-3beta attenuates glucocorticoid-induced bone loss. 23 Sep 2009
- Short-term effects of parathyroid hormone on rat lumbar vertebrae. 30 Aug 2009
- Pharmacological profile and clinical efficacy of minodronic acid hydrate as a new therapeutic agent for osteoporosis.
30 Aug 2009 - An Osteoblast-dependent mechanism contributes to the leptin regulation of insulin secretion. 30 Aug 2009
- Denosumab in men receiving androgen-deprivation therapy for prostate cancer. 9 Aug 2009
- Denosumab for prevention of fractures in postmenopausal women with osteoporosis. 9 Aug 2009
- US judge rules Merck won't face "punitive damages" in first Fosamax case. 4 Aug 2009
- Mandibular necrosis in beagle dogs treated with bisphosphonates. 30 Jul 2009
- Protein kinase C-delta transactivates platelet-derived growth factor receptor-alpha in mechanical strain-induced collagenase 3 (matrix metalloproteinase-13) expression by osteoblast-like cells. 22 Jul 2009
- Effects of teriparatide in postmenopausal women with osteoporosis on prior alendronate or raloxifene: differences between stopping and continuing the antiresorptive agent. 5 Jul 2009
- [Hormones and osteoporosis update. Androgen and bone remodeling] 29 Jun 2009
- Green tea and bone metabolism. 29 Jun 2009
- Low-dose transdermal estradiol induces breast density and heterogeneity changes comparable to those of raloxifene. 29 Jun 2009
- Progesterone effects on experimental tooth movement in rabbits. 29 Jun 2009
- [Bone remodeling: new therapeutic approaches] 8 Jun 2009
- Prospects for gene therapy of osteopetrosis. 30 May 2009
- Vitamin K treatment reduces undercarboxylated osteocalcin but does not alter bone turnover, density, or geometry in healthy postmenopausal North American women. 30 May 2009
- Nmp4/CIZ suppresses parathyroid hormone-induced increases in trabecular bone. 30 May 2009
- A theoretical model for simulating effect of parathyroid hormone on bone metabolism at cellular level. 30 May 2009
See a longer list of these articles.
Technical information about 'Bone Remodeling'
Definition: The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.
Descriptor UI: D016723
Alternative terms: Bone Remodeling; Remodeling, Bone;
Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects; ethics;
Tree Number: G11.427.590.195; G16.100.856.150;
History Note: 92
Technical Notes: note category: an aspect of bone physiol