Botulinum Toxins - Research News and Information

Thursday, January 08, 2009

[Cervical dystonia--diagnosis and treatment]

7 Oct 2008 BACKGROUND: Cervical dystonia is a focal dystonia of the neck muscles, leading to involuntary head movement, abnormal postures and pain. As effective treatment is available, all doctors should be able to recognize this potentially disabling ... Read more...

A new technique for subscapularis muscle needle insertion.

30 Aug 2008 OBJECTIVE: To investigate a new technique for needle insertion into the subscapularis muscle for botulinum toxin injection, nerve block with phenol, and electromyography. DESIGN: A new technique, which we have termed the inferior approach, was ... Read more...

Anterocollis: clinical features and treatment options.

30 Aug 2008 BACKGROUND: Anterocollis (AC) is a form of cervical dystonia (CD) that produces patterned, repetitive muscle contractions that result in neck flexion. It has been mainly described in the context of parkinsonian movement disorders including ... Read more...

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Latest indexed articles for 'Botulinum Toxins'

These are the very latest articles for this heading:

• [Cervical dystonia--diagnosis and treatment] 7 Oct 2008
• The binding sites on botulinum neurotoxin B for synaptotagmin and for blocking antibodies. 13 Sep 2008
• A new technique for subscapularis muscle needle insertion. 30 Aug 2008
• Anterocollis: clinical features and treatment options. 30 Aug 2008
• ADP-ribosylation of actin by the Clostridium botulinum C2 toxin in mammalian cells results in delayed caspase-dependent apoptotic cell death. 16 Aug 2008
• Quantitative real-time reverse transcription-PCR analysis reveals stable and prolonged neurotoxin cluster gene activity in a Clostridium botulinum type E strain at refrigeration temperature. 13 Aug 2008
• Highly specific interactions between botulinum neurotoxins and synaptic vesicle proteins. 30 Jul 2008
• [Tremor. Differential diagnosis and treatment] 30 Jul 2008
• Hyperhidrosis and botulinum toxin: expanding horizons. 30 Jul 2008
• Pilocarpine for the treatment of refractory dry mouth (xerostomia) associated with botulinum toxin type B. 30 Jul 2008
• Anal fissure: a review. 30 Jul 2008
• Characterization of new formalin-detoxified botulinum neurotoxin toxoids. 28 Jul 2008
• SNAP-25 substrate peptide (residues 180-183) binds to but bypasses cleavage by catalytically active Clostridium botulinum neurotoxin E. 23 Jul 2008
• Amino acid residues involved in membrane insertion and pore formation of Clostridium botulinum C2 toxin. 16 Jul 2008
• Dominant antigenic peptides located at the heavy chain terminal of botulinum neurotoxin B contain receptor-binding sites for synaptotagmin II. 15 Jul 2008
• New insights into the pharmacology of the bladder. 29 Jun 2008
• Recent advances in the treatment of urinary incontinence in older women. 29 Jun 2008
• Safety profile of multilevel chemical denervation procedures using phenol or botulinum toxin or both in a pediatric population. 29 Jun 2008
• Recent advances in the pharmacotherapy of chronic anal fissure: an update. 29 Jun 2008
• Botulinum toxin products overview. 29 Jun 2008

See a longer list of these articles.

Technical information about 'Botulinum Toxins'

Definition: Proteins synthesized as a single chain of ~150 kDa with 35% sequence identity to TETANUS TOXIN that is cleaved to a light and a heavy chain that are linked by a single disulfide bond. They have neuro-, entero-, and hemotoxic properties, are immunogenic, and include the most potent poisons known. The most commonly used apparently blocks release of ACETYLCHOLINE at cholinergic SYNAPSES.

Registry Number: 0

Descriptor UI: D001905

Alternative terms: Botulinum Toxins; Toxins, Botulinum; Botulinum Toxin; Toxin, Botulinum; Clostridium botulinum Toxins; Toxins, Clostridium botulinum; botulinum Toxins, Clostridium; Botulin;

Related Mesh Headings: Botulism;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Anti-Dyskinesia Agents; Poisons;

Tree Number: D12.776.097.156; D23.946.123.179;

Online Note: use BOTULINUM TOXINS to search BOTULINUM TOXIN 1969-77 (as Prov 1969-71)

History Note: 78; was BOTULINUM TOXIN 1969-77 (Prov 1969-71)

Technical Notes: /antag permitted but consider also BOTULINUM ANTITOXIN