Brain - Drug effects
Research News and Information

Saturday, November 21, 2009

Ex vivo [11C]-(+)-PHNO binding is unchanged in animal models displaying increased high-affinity states of the D2 receptor in vitro.

30 Oct 2009 Dopamine (DA) D2 receptor supersensitivity has been linked to an increase in the density of the D2 high-affinity state as measured in vitro. The two- affinity-state model of the D2 receptor predicts that the ex vivo specific binding of ... Read more...

Tonabersat, a novel gap-junction modulator for the prevention of migraine.

30 Oct 2009 Migraine is a common, recurrent, primary headache disorder associated with significant morbidity as well as high direct and indirect costs. Despite its impact, only a proportion of migraineurs who meet criteria for prophylactic treatment take ... Read more...

Neurological mechanisms of migraine: potential of the gap-junction modulator tonabersat in prevention of migraine.

30 Oct 2009 Migraine is a neurovascular disorder characterized by recurrent episodic headaches, and is caused by abnormal processing of sensory information due to peripheral and/or central sensitization. The exact pathophysiological mechanism underlying ... Read more...

Latest indexed articles for 'Brain - Drug effects'

These are the very latest articles for this heading:

• Ex vivo [11C]-(+)-PHNO binding is unchanged in animal models displaying increased high-affinity states of the D2 receptor in vitro. 30 Oct 2009
• Tonabersat, a novel gap-junction modulator for the prevention of migraine. 30 Oct 2009
• Neurological mechanisms of migraine: potential of the gap-junction modulator tonabersat in prevention of migraine. 30 Oct 2009
• Metoprolol reduces cerebral tissue oxygen tension after acute hemodilution in rats. 30 Oct 2009
• A PPARdelta agonist reduces amyloid burden and brain inflammation in a transgenic mouse model of Alzheimer's disease. 29 Sep 2009
• A neurocomputational model for cocaine addiction. 29 Sep 2009
• Turbocharging the brain. 29 Sep 2009
• The dopaminergic stabilizer ASP2314/ACR16 selectively interacts with D2(High) receptors. 29 Sep 2009
• Amphetamine and environmentally induced hyperthermia differentially alter the expression of genes regulating vascular tone and angiogenesis in the meninges and associated vasculature. 29 Sep 2009
• In vitro autoradiography and in vivo evaluation in cynomolgus monkey of [18F]FE-PE2I, a new dopamine transporter PET radioligand. 29 Sep 2009
• Low-dose kaolin-induced feline hydrocephalus and feline ventriculostomy: an updated model. 29 Sep 2009
• Management of acute ischemic stroke: current status of pharmacological and mechanical endovascular methods. 29 Sep 2009
• [Neuroenhancement: doping for the brain] 27 Sep 2009
• Combined administration of the mixture of honokiol and magnolol and ginger oil evokes antidepressant-like synergism in rats. 24 Sep 2009
• Selective estrogen receptor modulators decrease reactive astrogliosis in the injured brain: effects of aging and prolonged depletion of ovarian hormones. 22 Sep 2009
• A secretory phospholipase A2-mediated neuroprotection and anti-apoptosis. 21 Sep 2009
• Autism spectrum disorders following in utero exposure to antiepileptic drugs. 20 Sep 2009
• Histopathological changes of rat brain after direct injection of Hb-vesicles (artificial oxygen carriers) and neurological impact in an intracerebral hemorrhage model. 13 Sep 2009
• Pharmacologic interventions for stroke: looking beyond the thrombolysis time window into the penumbra with biomarkers, not a stopwatch. 8 Sep 2009
• Altered pH homeostasis modulates the glutathione peroxidase mimics and other antioxidant properties of diphenyl diselenide. 4 Sep 2009

See a longer list of these articles.

Technical information about 'Brain'

Definition: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.

Descriptor UI: D001921

Alternative terms: Brain; Brains; Encephalon; Encephalons;

Related Mesh Headings: Cerebral Decortication; Psychosurgery;

Allowable Qualifiers: abnormalities; anatomy & histology; blood supply; cytology; drug effects; embryology; enzymology; growth & development; immunology; metabolism; microbiology; parasitology; pathology; physiology; physiopathology; radiation effects; radiography; radionuclide imaging; secretion; surgery; ultrastructure; virology;

Tree Number: A08.186.211;

Online Note: pre-explosion = BRAIN (PX)

History Note: /enzymology was BRAIN ENZYMOLOGY 1964-65; /physiology was BRAIN PHYSIOLOGY 1965; BRAIN ELECTROPHYSIOLOGY was heading 1964-65

Technical Notes: general; /blood supply: consider also CEREBROVASCULAR CIRCULATION; CEREBRAL ARTERIES; CEREBRAL VEINS; CRANIAL SINUSES; /cytol: do not routinely convert to NEURONS; /surg: consider specific neurosurgical procedures in Category E4; inflammation = ENCEPHALITIS & its specifics; infarct = CEREBRAL INFARCTION; malacia = ENCEPHALOMALACIA; brain-isolated, encéphale isolé, cerveau isolé: index DECEREBRATE STATE