Bromodeoxyuridine - Metabolism
Research News and Information

Monday, November 23, 2009

SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice.

27 Oct 2009 Nuclear movement is critical during neurogenesis and neuronal migration, which are fundamental for mammalian brain development. Although dynein, Lis1, and other cytoplasmic proteins are known for their roles in connecting microtubules to the nucleus ... Read more...

Ionizing radiation impairs the formation of trace fear memories and reduces hippocampal neurogenesis.

29 Sep 2009 Long-term cognitive impairments are a feared consequence of therapeutic cranial irradiation in children as well as adults. Studies in animal models suggest that these deficits may be associated with a decrease in hippocampal granule cell ... Read more...

Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus.

22 Sep 2009 Disrupted-In-Schizophrenia 1 (DISC1), a susceptibility gene for major psychiatric disorders, regulates neuronal migration and differentiation during mammalian brain development. Although roles for DISC1 in postnatal neurogenesis in the dentate gyrus ... Read more...

Latest indexed articles for 'Bromodeoxyuridine - Metabolism'

These are the very latest articles for this heading:

• SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice. 27 Oct 2009
• Ionizing radiation impairs the formation of trace fear memories and reduces hippocampal neurogenesis. 29 Sep 2009
• Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus. 22 Sep 2009
• The role of granulocyte-colony stimulating factor (G-CSF) in the healthy brain: a characterization of G-CSF-deficient mice. 14 Sep 2009
• GM-CSF regulates intimal cell proliferation in nascent atherosclerotic lesions. 12 Sep 2009
• AP2gamma regulates basal progenitor fate in a region- and layer-specific manner in the developing cortex. 11 Sep 2009
• Myosin II is required for interkinetic nuclear migration of neural progenitors. 7 Sep 2009
• Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh. 4 Sep 2009
• Sex-specific modulation of cell proliferation by socially relevant stimuli in the adult green treefrog brain (Hyla cinerea). Sep 2009
• Is there such a thing as a renal stem cell? 25 Aug 2009
• Comparative study of regenerative potential of beta cells from young and aged donor mice using a novel islet transplantation model. 25 Aug 2009
• DNA damage signalling recruits RREB-1 to the p53 tumour suppressor promoter. 25 Aug 2009
• The role of IGF1 on the differentiation of prolactin secreting cells in the mouse anterior pituitary. 18 Aug 2009
• Dynamic Pax6 expression during the neurogenic cell cycle influences proliferation and cell fate choices of retinal progenitors. 15 Aug 2009
• SOX6 controls dorsal progenitor identity and interneuron diversity during neocortical development. 3 Aug 2009
• Mesenchymal stem cells promote oligodendroglial differentiation in hippocampal slice cultures. Aug 2009
• Fibroblast growth factor-9 inhibits astrocyte differentiation of adult mouse neural progenitor cells. 30 Jul 2009
• Fragile X mental retardation protein is required for chemically-induced long-term potentiation of the hippocampus in adult mice. 28 Jul 2009
• Stem cell proliferation and quiescence--two sides of the same coin. 22 Jul 2009
• Statistical and economical efficiency in assessment of liver regeneration using defined sample size and selection in combination with a fully automated image analysis system. 18 Jul 2009

See a longer list of these articles.

Technical information about 'Bromodeoxyuridine'

Definition: A nucleoside that substitutes for thymidine in DNA and thus acts as an antimetabolite. It causes breaks in chromosomes and has been proposed as an antiviral and antineoplastic agent. It has been given orphan drug status for use in the treatment of primary brain tumors.

Chemical name: Uridine, 5-bromo-2'-deoxy-

Registry Number: 59-14-3

Descriptor UI: D001973

Alternative terms: Bromodeoxyuridine; Bromouracil Deoxyriboside; Deoxyriboside, Bromouracil; 5-Bromo-2'-deoxyuridine; 5 Bromo 2' deoxyuridine; BrdU; BUdR; 5-Bromodeoxyuridine; 5 Bromodeoxyuridine; Broxuridine; NSC-38297;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Antimetabolites; Antimetabolites, Antineoplastic; Antiviral Agents; Radiation-Sensitizing Agents;

Tree Number: D03.383.742.680.852.300.150; D13.570.230.430.196; D13.570.685.852.300.150;

History Note: 66(65)