Bromodeoxyuridine
Research News and Information

Sunday, November 22, 2009

The PPARalpha agonist fenofibrate preserves hippocampal neurogenesis and inhibits microglial activation after whole-brain irradiation.

30 Oct 2009 PURPOSE: Whole-brain irradiation (WBI) leads to cognitive impairment months to years after radiation. Numerous studies suggest that decreased hippocampal neurogenesis and microglial activation are involved in the pathogenesis of WBI-induced brain ... Read more...

SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice.

27 Oct 2009 Nuclear movement is critical during neurogenesis and neuronal migration, which are fundamental for mammalian brain development. Although dynein, Lis1, and other cytoplasmic proteins are known for their roles in connecting microtubules to the nucleus ... Read more...

Ionizing radiation impairs the formation of trace fear memories and reduces hippocampal neurogenesis.

29 Sep 2009 Long-term cognitive impairments are a feared consequence of therapeutic cranial irradiation in children as well as adults. Studies in animal models suggest that these deficits may be associated with a decrease in hippocampal granule cell ... Read more...

Latest indexed articles for 'Bromodeoxyuridine'

These are the very latest articles for this heading:

• The PPARalpha agonist fenofibrate preserves hippocampal neurogenesis and inhibits microglial activation after whole-brain irradiation. 30 Oct 2009
• SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice. 27 Oct 2009
• Ionizing radiation impairs the formation of trace fear memories and reduces hippocampal neurogenesis. 29 Sep 2009
• Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus. 22 Sep 2009
• LTD induction suppresses LTP-induced hippocampal adult neurogenesis. 21 Sep 2009
• The role of granulocyte-colony stimulating factor (G-CSF) in the healthy brain: a characterization of G-CSF-deficient mice. 14 Sep 2009
• GM-CSF regulates intimal cell proliferation in nascent atherosclerotic lesions. 12 Sep 2009
• AP2gamma regulates basal progenitor fate in a region- and layer-specific manner in the developing cortex. 11 Sep 2009
• Myosin II is required for interkinetic nuclear migration of neural progenitors. 7 Sep 2009
• Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh. 4 Sep 2009
• Sex-specific modulation of cell proliferation by socially relevant stimuli in the adult green treefrog brain (Hyla cinerea). Sep 2009
• Prenatal phencyclidine exposure alters hippocampal cell proliferation in offspring rats. 30 Aug 2009
• Is there such a thing as a renal stem cell? 25 Aug 2009
• Comparative study of regenerative potential of beta cells from young and aged donor mice using a novel islet transplantation model. 25 Aug 2009
• DNA damage signalling recruits RREB-1 to the p53 tumour suppressor promoter. 25 Aug 2009
• Distinction of the memory B cell response to cognate antigen versus bystander inflammatory signals. 22 Aug 2009
• The role of IGF1 on the differentiation of prolactin secreting cells in the mouse anterior pituitary. 18 Aug 2009
• Extracellular ADP regulates lesion-induced in vivo cell proliferation and death in the zebrafish retina. 17 Aug 2009
• Dynamic Pax6 expression during the neurogenic cell cycle influences proliferation and cell fate choices of retinal progenitors. 15 Aug 2009
• Enigmatic central canal contacting cells: immature neurons in "standby mode"? 10 Aug 2009

See a longer list of these articles.

Technical information about 'Bromodeoxyuridine'

Definition: A nucleoside that substitutes for thymidine in DNA and thus acts as an antimetabolite. It causes breaks in chromosomes and has been proposed as an antiviral and antineoplastic agent. It has been given orphan drug status for use in the treatment of primary brain tumors.

Chemical name: Uridine, 5-bromo-2'-deoxy-

Registry Number: 59-14-3

Descriptor UI: D001973

Alternative terms: Bromodeoxyuridine; Bromouracil Deoxyriboside; Deoxyriboside, Bromouracil; 5-Bromo-2'-deoxyuridine; 5 Bromo 2' deoxyuridine; BrdU; BUdR; 5-Bromodeoxyuridine; 5 Bromodeoxyuridine; Broxuridine; NSC-38297;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Antimetabolites; Antimetabolites, Antineoplastic; Antiviral Agents; Radiation-Sensitizing Agents;

Tree Number: D03.383.742.680.852.300.150; D13.570.230.430.196; D13.570.685.852.300.150;

History Note: 66(65)