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Bronchiolitis Obliterans - Genetics
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Definition of 'Bronchiolitis Obliterans'

Inflammation of the BRONCHIOLES leading to an obstructive lung disease. Bronchioles are characterized by fibrous granulation tissue with bronchial exudates in the lumens. Clinical features include a nonproductive cough and DYSPNEA.

Common names: Bronchiolitis Obliterans; Constrictive Bronchiolitis; Bronchiolitides, Constrictive; Bronchiolitis, Constrictive; Constrictive Bronchiolitides; Bronchiolitis, Exudative; Bronchiolitides, Exudative; Exudative Bronchiolitides; Exudative Bronchiolitis; Bronchiolitis, Proliferative

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Monday, November 23, 2009

Attenuation of obliterative bronchiolitis by a CXCR4 antagonist in the murine heterotopic tracheal transplant model.

29 Nov 2008 BACKGROUND: Long-term success in lung transplantation is limited by obliterative bronchiolitis (OB), yet the mechanism for this disease is not well understood. Chemokine SDF-1 and its receptor, CXCR4, have been reported to be involved in several ... Read more...


Recipient NOD2/CARD15 variants: a novel independent risk factor for the development of bronchiolitis obliterans after allogeneic stem cell transplantation.

30 Dec 2007 Bronchiolitis obliterans (BO) is a serious complication after allogeneic stem cell transplantation. We hypothesized that single nucleotide polymorphisms (SNPs) of the NOD2/CARD15 gene (=NOD2/CARD15 variants) contribute to changes in host defense and ... Read more...


[The mechanism of transforming growth factor beta1 in myofibroblast differentiation]

13 Jul 2007 OBJECTIVE: To investigate the mechanism underlying myofibroblast differentiation induced by transforming growth factor (TGF) beta1 in obliterative bronchiolitis following lung transplantation. METHODS: Heterotopic tracheal transplantation was ... Read more...

 

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Technical information about 'Bronchiolitis Obliterans'

Definition: Inflammation of the BRONCHIOLES leading to an obstructive lung disease. Bronchioles are characterized by fibrous granulation tissue with bronchial exudates in the lumens. Clinical features include a nonproductive cough and DYSPNEA.

Descriptor UI: D001989

Alternative terms: Bronchiolitis Obliterans; Constrictive Bronchiolitis; Bronchiolitides, Constrictive; Bronchiolitis, Constrictive; Constrictive Bronchiolitides; Bronchiolitis, Exudative; Bronchiolitides, Exudative; Exudative Bronchiolitides; Exudative Bronchiolitis; Bronchiolitis, Proliferative; Bronchiolitides, Proliferative; Proliferative Bronchiolitides; Proliferative Bronchiolitis;

Allowable Qualifiers: blood; cerebrospinal fluid; chemically induced; classification; complications; congenital; diagnosis; diet therapy; drug therapy; economics; embryology; enzymology; ethnology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; radiotherapy; rehabilitation; surgery; therapy; urine; veterinary; ultrasonography; virology;

Tree Number: C08.127.446.135.140; C08.381.495.146.135.140;

History Note: 88

Technical Notes: do not confuse with BRONCHIOLITIS OBLITERANS ORGANIZING PNEUMONIA see CRYPTOGENIC ORGANIZING PNEUMONIA

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